DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and PXY

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_200956.1	Gene:	PXY / 836269	AraportID:	AT5G61480	Length:	1041	Species:	Arabidopsis thaliana

Alignment Length:	929	Identity:	191/929 - (20%)
Similarity:	293/929 - (31%)	Gaps:	359/929 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1408 SLGCSVSQEV-NLNNL----IYEQ---RSAPSSSSSSASVSQGLRRILLMTY--------FPSGF 1456
            ||..|:.||: ||:||    :::.   ...|.|.|:       |:.:.|:.:        .||||
plant   260 SLSGSLPQELGNLSNLETLFLFQNGFTGEIPESYSN-------LKSLKLLDFSSNQLSGSIPSGF 317

  Fly  1457 -------WSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQ---TGLALY-- 1509
                   |..||:..|:.| :.|.|                ..|.:.|...||.   ||:..:
plant   318 STLKNLTWLSLISNNLSGE-VPEGI----------------GELPELTTLFLWNNNFTGVLPHKL 365

  Fly  1510 ------------------------------YGPILIFKIWEVPFQKT----ERTQPFRTDGNRFK 1540
                                          |..||...::|....|:    |....||:..||..
plant   366 GSNGKLETMDVSNNSFTGTIPSSLCHGNKLYKLILFSNMFEGELPKSLTRCESLWRFRSQNNRLN 430

  Fly  1541 LKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLL 1605
                   ..:.:...|:..:.|          ||.:..:...:| |.....|.:|.
plant   431 -------GTIPIGFGSLRNLTF----------VDLSNNRFTDQI-PADFATAPVLQ--------- 468

  Fly  1606 LEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDR----EVPP-VGCNRPSRSS 1665
                |.:|.|.|.|..           .|..:||....|....|..    |:|. |||....|..
plant   469 ----YLNLSTNFFHRK-----------LPENIWKAPNLQIFSASFSNLIGEIPNYVGCKSFYRIE 518

  Fly  1666 RRGAGAYFLHGVGDPGEDG------ALNVFSAYLNATARRERRSEDSLGAGSDAD------SGVG 1718
            .:|..   |:|. .|.:.|      .||:...:||.....|..:..|:   :|.|      :|..
plant   519 LQGNS---LNGT-IPWDIGHCEKLLCLNLSQNHLNGIIPWEISTLPSI---ADVDLSHNLLTGTI 576

  Fly  1719 PDSAGSSR----------------------------------------------------NTSVD 1731
            |...|||:                                                    |..:|
plant   577 PSDFGSSKTITTFNVSYNQLIGPIPSGSFAHLNPSFFSSNEGLCGDLVGKPCNSDRFNAGNADID 641

  Fly  1732 GHPGYHLPDNSNVCYAWMI--------------EECILSVY---------NQSKISCPVHLE--Q 1771
            ||.....|..:.....|::              ..|....|         |...|. |..|.  |
plant   642 GHHKEERPKKTAGAIVWILAAAIGVGFFVLVAATRCFQKSYGNRVDGGGRNGGDIG-PWKLTAFQ 705

  Fly  1772 SMAQLAPDVIFADIPDKHTIPSECIIK-GSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVP 1835
            .:...|.||:            ||:.| .::||.|:.|.|:||.                   :|
plant   706 RLNFTADDVV------------ECLSKTDNILGMGSTGTVYKAE-------------------MP 739

  Fly  1836 PGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--LAL 1898
            .|      .::|.|...||...:......|:...|  |:.||..::|.|||.|:|.|...  ..|
plant   740 NG------EIIAVKKLWGKNKENGKIRRRKSGVLA--EVDVLGNVRHRNIVRLLGCCTNRDCTML 796

  Fly  1899 VLELAPLGGLDALLRHYRRSGAHMGPHTFQT---------LVLQAARAIEYLHR---RRIIYRDL 1951
            :.|..|.|.||.||        |.|..|...         :.:..|:.|.|||.   ..|::|||
plant   797 LYEYMPNGSLDDLL--------HGGDKTMTAAAEWTALYQIAIGVAQGICYLHHDCDPVIVHRDL 853

  Fly  1952 KSENVLVWELPQPHTEDSPRNLVHIKIADYGISR--QTAPSGAKGFGGTEGFMAPEIIRYNGEEE 2014
            |..|:|:         |:.   ...::||:|:::  ||..| .....|:.|::|||   |....:
plant   854 KPSNILL---------DAD---FEARVADFGVAKLIQTDES-MSVVAGSYGYIAPE---YAYTLQ 902

  Fly  2015 YTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRE--------TQFPTC----- 2066
            ..:|.|.:|:|:.:.|.|:.::..|........|::..|..|..:|        :...:|
plant   903 VDKKSDIYSYGVILLEIITGKRSVEPEFGEGNSIVDWVRSKLKTKEDVEEVLDKSMGRSCSLIRE 967

  Fly  2067 ----CLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKI--------------- 2112
                .|.:.:||....|..||....::.||..          |.|..:.:
plant   968 EMKQMLRIALLCTSRSPTDRPPMRDVLLILQE----------AKPKRKTVGDNVIVVGDVNDVNF 1022

  Fly  2113 --VCGVFQSLVGMGDDERC 2129
              ||.     |.:|.|.:|
plant  1023 EDVCS-----VDVGHDVKC 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713	23/85 (27%)
		STYKc	1796..2092	CDD:214568	80/329 (24%)
		STKc_LRRK	1801..2095	CDD:270902	81/326 (25%)
PXY	NP_200956.1	PLN00113	61..1000	CDD:215061	183/886 (21%)
		leucine-rich repeat	85..106	CDD:275380
		leucine-rich repeat	107..130	CDD:275380
		leucine-rich repeat	131..162	CDD:275380
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	203..226	CDD:275380
		leucine-rich repeat	227..250	CDD:275380
		leucine-rich repeat	251..274	CDD:275380	7/13 (54%)
		leucine-rich repeat	275..298	CDD:275380	5/29 (17%)
		leucine-rich repeat	299..322	CDD:275380	5/22 (23%)
		leucine-rich repeat	323..346	CDD:275380	8/39 (21%)
		leucine-rich repeat	347..370	CDD:275380	5/22 (23%)
		leucine-rich repeat	371..394	CDD:275380	0/22 (0%)
		leucine-rich repeat	395..418	CDD:275380	5/22 (23%)
		leucine-rich repeat	419..442	CDD:275380	5/29 (17%)
		leucine-rich repeat	443..462	CDD:275380	5/29 (17%)
		leucine-rich repeat	467..537	CDD:275380	22/97 (23%)
		leucine-rich repeat	491..513	CDD:275378	7/21 (33%)
		leucine-rich repeat	538..561	CDD:275380	5/22 (23%)
		leucine-rich repeat	562..582	CDD:275380	4/22 (18%)
		leucine-rich repeat	586..608	CDD:275380	0/21 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050