DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and MOL1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_199948.1	Gene:	MOL1 / 835209	AraportID:	AT5G51350	Length:	895	Species:	Arabidopsis thaliana

Alignment Length:	742	Identity:	154/742 - (20%)
Similarity:	276/742 - (37%)	Gaps:	221/742 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 VNLLCGAARETALLAAVRGGHLDVVQSLLQHGAN-----PNIVAKPVEDHNDPKCCEEIYGLSNV 411
            :.|:..|..:|..|..::....|...||.....|     .|:||          ||    ..|.|
plant    19 LTLVAAAEPQTESLLTLKSQLTDNFNSLKDWFINTPEVSDNLVA----------CC----SWSGV 69

  Fly   412 PIAEACKQRSLAM--LDLLLKHGARDDNGTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGL 474
                .|.|.|.::  :||..|:.|...:|.         :..:.:.||...:   ||   |....
plant    70 ----RCNQNSTSVVSVDLSSKNLAGSLSGK---------EFLVFTELLELNI---SD---NSFSG 115

  Fly   475 PTPVEV-----NVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQ 534
            ..|.|:     |:.....|..::|..||      |.:...||::
plant   116 EFPAEIFFNMTNLRSLDISRNNFSGRFP------DGNGGDSSLK--------------------- 153

  Fly   535 SHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKIT-DLPAPIGQTYGCPVLDE 598
                 |.:.|.|:     |::....:|..|..|.:|:.||:|.:..| .:|:..|....   |:.
plant   154 -----NLIFLDAL-----SNSFSGPLPIHLSQLENLKVLNLAGSYFTGSIPSQYGSFKN---LEF 205

  Fly   599 LFLQDNQLT-TLPAAIFHLPALSILDVSNNKLQ-QLPFDLWRAPKLRELNVA-FNLLRDLPVPPM 660
            |.|..|.|: .:|..:.:|..|:.:::..|..: .:|:::....:|:.|::| .||...||
plant   206 LHLGGNLLSGHIPQELGNLTTLTHMEIGYNSYEGVIPWEIGYMSELKYLDIAGANLSGFLP---- 266

  Fly   661 QTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAG 725
            :..|:|..|:.|.|                    .||..|       .::.|    :||:
plant   267 KHFSNLTKLESLFL--------------------FRNHLS-------REIPW----ELGE----- 295

  Fly   726 VGSSQLSSLNIA-NNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEIS 789
              .:.|.:|::: |::..:||.:...|. ||..||:.:|.:..     :.|..:.||. |.:.:.
plant   296 --ITSLVNLDLSDNHISGTIPESFSGLK-NLRLLNLMFNEMSG-----TLPEVIAQLP-SLDTLF 351

  Fly   790 CWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSS-------SATSFRASVLKSVCRHR 847
            .|.:             |....||:          |.|.:|       |..||:..:.:.:|.
plant   352 IWNN-------------YFSGSLPK----------SLGMNSKLRWVDVSTNSFQGEIPQGICS-- 391

  Fly   848 RHLRLEALRTLILADNLLTRIQLSTDDATTLFN-ESEDADWS-VVGVNRSKVIFPNLSMLDMTNN 910
               |....:.::.::|....:..|..:.:||.. ..||..:| |:..:.|::  |::|.:|::.|
plant   392 ---RGVLFKLILFSNNFTGTLSPSLSNCSTLVRIRLEDNSFSGVIPFSFSEI--PDISYIDLSRN 451

  Fly   911 CLK-EIPASLHELSSLSVLNISGNVNI-TELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHK 973
            .|. .||..:.:.:.|...|||.|..: .:||||:.....|.|.:...|.:...| .:.||.|..
plant   452 KLTGGIPLDISKATKLDYFNISNNPELGGKLPPHIWSAPSLQNFSASSCSISGGL-PVFESCKSI 515

  Fly   974 TM------DIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASE 1032
            |:      :|.|                ::...|:..|....:||         |.::.|.....
plant   516 TVIELSNNNISG----------------MLTPTVSTCGSLKKMDL---------SHNNLRGAIPS 555

  Fly  1033 NHWAKRMGHARSTSRSHRHSSASSANI 1059
            :...:.||         :|:..|:||:
plant   556 DKVFQSMG---------KHAYESNANL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560	9/41 (22%)
		ANK	361..477	CDD:238125	26/122 (21%)
		ANK repeat	361..390	CDD:293786	7/33 (21%)
		Ank_2	364..464	CDD:289560	22/106 (21%)
		ANK repeat	406..435	CDD:293786	9/30 (30%)
		ANK repeat	437..464	CDD:293786	3/26 (12%)
		LRR_8	<544..580	CDD:290566	10/35 (29%)
		leucine-rich repeat	547..569	CDD:275380	4/21 (19%)
		LRR_8	569..629	CDD:290566	16/61 (26%)
		leucine-rich repeat	570..595	CDD:275380	7/25 (28%)
		leucine-rich repeat	596..618	CDD:275380	7/22 (32%)
		leucine-rich repeat	619..641	CDD:275380	3/22 (14%)
		leucine-rich repeat	642..676	CDD:275380	12/34 (35%)
		leucine-rich repeat	677..730	CDD:275380	6/52 (12%)
		LRR_8	729..788	CDD:290566	15/59 (25%)
		leucine-rich repeat	731..754	CDD:275380	6/23 (26%)
		LRR_8	855..933	CDD:290566	20/80 (25%)
		leucine-rich repeat	855..901	CDD:275380	9/47 (19%)
		leucine-rich repeat	902..924	CDD:275380	6/22 (27%)
		leucine-rich repeat	925..949	CDD:275380	9/24 (38%)
		P-loop_NTPase	993..1211	CDD:304359	12/67 (18%)
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
MOL1	NP_199948.1	PLN00113	2..890	CDD:215061	154/742 (21%)
		LRRNT_2	25..72	CDD:285463	14/64 (22%)
		leucine-rich repeat	78..102	CDD:275380	5/32 (16%)
		leucine-rich repeat	103..127	CDD:275380	7/29 (24%)
		leucine-rich repeat	128..178	CDD:275380	14/86 (16%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		leucine-rich repeat	227..250	CDD:275380	3/22 (14%)
		leucine-rich repeat	251..274	CDD:275380	9/26 (35%)
		leucine-rich repeat	275..298	CDD:275380	9/60 (15%)
		leucine-rich repeat	299..322	CDD:275380	6/23 (26%)
		leucine-rich repeat	323..346	CDD:275380	7/28 (25%)
		LRR_RI	337..549	CDD:238064	56/268 (21%)
		leucine-rich repeat	347..365	CDD:275380	4/40 (10%)
		leucine-rich repeat	371..394	CDD:275380	5/27 (19%)
		leucine-rich repeat	395..416	CDD:275380	2/20 (10%)
		leucine-rich repeat	419..442	CDD:275380	6/24 (25%)
		leucine-rich repeat	467..491	CDD:275380	9/23 (39%)
		leucine-rich repeat	515..538	CDD:275380	4/38 (11%)
		PKc_like	652..889	CDD:304357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050