DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and EFR

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001318610.1	Gene:	EFR / 832170	AraportID:	AT5G20480	Length:	1031	Species:	Arabidopsis thaliana

Alignment Length:	1206	Identity:	234/1206 - (19%)
Similarity:	408/1206 - (33%)	Gaps:	431/1206 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 MAITCG--DEAILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDW 505
            :.:|||  .|.::|              :|..|...   ..|..||..|:|:..:.    .:.|
plant    64 IGVTCGRRRERVIS--------------LNLGGFKL---TGVISPSIGNLSFLRLL----NLAD- 106

  Fly   506 HSMGSSVQLSV---VRVPWMVSGVLLLNPKLQSHPRLNEVALTAITR---IDFSHNVL-TSIPQE 563
            :|.||::...|   .|:.::.....||..::.|       :|:..:|   :|.|.|.| ..:|.|
plant   107 NSFGSTIPQKVGRLFRLQYLNMSYNLLEGRIPS-------SLSNCSRLSTVDLSSNHLGHGVPSE 164

  Fly   564 LFHLVSLRYLNVAQNKIT-DLPAPIGQTYGCPVLDELFLQDN--------QLTTL---------- 609
            |..|..|..|::::|.:| :.||.:|.......||..:.|..        :||.:
plant   165 LGSLSKLAILDLSKNNLTGNFPASLGNLTSLQKLDFAYNQMRGEIPDEVARLTQMVFFQIALNSF 229

  Fly   610 ----PAAIFHLPALSILDVSNNKLQ-QLPFDL-WRAPKLRELNVAFNLLRDLPVPPMQTSSSLLS 668
                |.|::::.:|..|.:::|... .|..|. :..|.||.|.:..|.... .:|  :|.:::.|
plant   230 SGGFPPALYNISSLESLSLADNSFSGNLRADFGYLLPNLRRLLLGTNQFTG-AIP--KTLANISS 291

  Fly   669 LDKLNLQSFEEPPSNKPRNVTQQRL-----THRNLWSATLDITDNDMKWQHEQDLGDGKTAG--- 725
            |::.::.|          |.....:     ..||||  .|.|.:|        .||:..::|
plant   292 LERFDISS----------NYLSGSIPLSFGKLRNLW--WLGIRNN--------SLGNNSSSGLEF 336

  Fly   726 VGS----SQLSSLNIA-NNLFTSIPAALPCLAVNLTRLNMSYNSL-----RSMGHVTSYPATLKQ 780
            :|:    :||..|::. |.|...:||::..|:..||.|.:..|.:     ..:|::.|    |::
plant   337 IGAVANCTQLEYLDVGYNRLGGELPASIANLSTTLTSLFLGQNLISGTIPHDIGNLVS----LQE 397

  Fly   781 LDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSS-------------SA 832
            |.|..|.:|  ..||   .|...||....|.|       |..|.|....|             ::
plant   398 LSLETNMLS--GELP---VSFGKLLNLQVVDL-------YSNAISGEIPSYFGNMTRLQKLHLNS 450

  Fly   833 TSFRASVLKSV--CRH----------------RRHLRLEALRTLILADNLLT--------RIQLS 871
            .||...:.:|:  ||:                :..|::.:|..:.|::|.||        :::|.
plant   451 NSFHGRIPQSLGRCRYLLDLWMDTNRLNGTIPQEILQIPSLAYIDLSNNFLTGHFPEEVGKLELL 515

  Fly   872 TDDATT--------------------LFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLK-EI 915
            .....:                    ||.:....|.::..::|    ..:|..:|.:||.|. .|
plant   516 VGLGASYNKLSGKMPQAIGGCLSMEFLFMQGNSFDGAIPDISR----LVSLKNVDFSNNNLSGRI 576

  Fly   916 PASLHELSSLSVLNIS-----GNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMI---ESKKH 972
            |..|..|.||..||:|     |.|..|.:..:...:|...|.|..|.:.:..|:..|   ..:|.
plant   577 PRYLASLPSLRNLNLSMNKFEGRVPTTGVFRNATAVSVFGNTNICGGVREMQLKPCIVQASPRKR 641

  Fly   973 KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLL-------------RQGAGSGSSSS 1024
            |                |.:..|.:|.|:. ||.::||.::             :..|..|:.|.
plant   642 K----------------PLSVRKKVVSGIC-IGIASLLLIIIVASLCWFMKRKKKNNASDGNPSD 689

  Fly  1025 SHRSRASENHWAKRMGHARSTSRSHRHSSAS---SANISTVGVDIGTWICEKRKRAPGSHGP--- 1083
            |    .:...:.:::.:....|.:.|.||.:   |.|...|              ..|..||
plant   690 S----TTLGMFHEKVSYEELHSATSRFSSTNLIGSGNFGNV--------------FKGLLGPENK 736

  Fly  1084 ----VVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVI 1144
                .|......|..|.:.|..:.|...|            |:.|.:|:....::.:.
plant   737 LVAVKVLNLLKHGATKSFMAECETFKGIR------------HRNLVKLITVCSSLDSE------- 782

  Fly  1145 IVGTHFDAVGESISPQ-------KAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIH 1202
              |..|.|:.....|:       :.|.|:: :.:...::..|||:
plant   783 --GNDFRALVYEFMPKGSLDMWLQLEDLER-VNDHSRSLTPAEKL-------------------- 824

  Fly  1203 LLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTE 1267
               ||..|.|..|                                                   |
plant   825 ---NIAIDVASAL---------------------------------------------------E 835

  Fly  1268 QMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVVTVREINPFA 1332
            .:.:|                 ||                   ||...||:             .
plant   836 YLHVH-----------------CH-------------------DPVAHCDI-------------K 851

  Fly  1333 PTGVMKLDDL----------QMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSL---- 1383
            |:.::..|||          |:|::.       :|.   |.||:|..|....:.....|..
plant   852 PSNILLDDDLTAHVSDFGLAQLLYKY-------DRE---SFLNQFSSAGVRGTIGYAAPEYGMGG 906

  Fly  1384 LPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILL 1448
            .||.:....:.| .:.|...|..:....|.:.:.||::......|..:||..|.::.:|||.:|.
plant   907 QPSIQGDVYSFG-ILLLEMFSGKKPTDESFAGDYNLHSYTKSILSGCTSSGGSNAIDEGLRLVLQ 970

  Fly  1449 MTYFPSGFWSRLITRILADEQIIE--AIRGVYMASQ 1482
            :....|..:.|  .|:..||.:.|  :||..:.:|:
plant   971 VGIKCSEEYPR--DRMRTDEAVRELISIRSKFFSSK 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125	7/35 (20%)
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560	5/22 (23%)
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786	5/22 (23%)
		LRR_8	<544..580	CDD:290566	13/39 (33%)
		leucine-rich repeat	547..569	CDD:275380	9/25 (36%)
		LRR_8	569..629	CDD:290566	17/82 (21%)
		leucine-rich repeat	570..595	CDD:275380	7/25 (28%)
		leucine-rich repeat	596..618	CDD:275380	7/43 (16%)
		leucine-rich repeat	619..641	CDD:275380	5/23 (22%)
		leucine-rich repeat	642..676	CDD:275380	8/33 (24%)
		leucine-rich repeat	677..730	CDD:275380	12/64 (19%)
		LRR_8	729..788	CDD:290566	18/64 (28%)
		leucine-rich repeat	731..754	CDD:275380	7/23 (30%)
		LRR_8	855..933	CDD:290566	24/111 (22%)
		leucine-rich repeat	855..901	CDD:275380	10/73 (14%)
		leucine-rich repeat	902..924	CDD:275380	9/22 (41%)
		leucine-rich repeat	925..949	CDD:275380	8/28 (29%)
		P-loop_NTPase	993..1211	CDD:304359	41/247 (17%)
		COR	1230..1471	CDD:292713	42/254 (17%)
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
EFR	NP_001318610.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050