DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and EMS1

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_196345.1 Gene:EMS1 / 830619 AraportID:AT5G07280 Length:1192 Species:Arabidopsis thaliana


Alignment Length:1716 Identity:344/1716 - (20%)
Similarity:572/1716 - (33%) Gaps:650/1716 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 VNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLN----------PK-L 533
            |::...:||.||:.....|...:..|:...|:.....|.|..::..|..|:          || :
plant    21 VDLSSETTSLISFKRSLENPSLLSSWNVSSSASHCDWVGVTCLLGRVNSLSLPSLSLRGQIPKEI 85

  Fly   534 QSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITD-LPAPIGQTYGCPVLD 597
            .|...|.|:.|.       .:.....||.|:::|..|:.|:::.|.:|. ||..:.:   .|.|.
plant    86 SSLKNLRELCLA-------GNQFSGKIPPEIWNLKHLQTLDLSGNSLTGLLPRLLSE---LPQLL 140

  Fly   598 ELFLQDNQLT-TLPAAIF-HLPALSILDVSNNKLQ-QLPFDLWRAPKLRELNVAFNLLRDLPVPP 659
            .|.|.||..: :||.:.| .|||||.||||||.|. ::|      |::.:|:...||...|....
plant   141 YLDLSDNHFSGSLPPSFFISLPALSSLDVSNNSLSGEIP------PEIGKLSNLSNLYMGLNSFS 199

  Fly   660 MQTSSSL--LSLDKLNLQSFEEPPS--NKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGD 720
            .|..|.:  :||    |::|..|..  |.|......:|.|    .|.||::.|.:|....:..| 
plant   200 GQIPSEIGNISL----LKNFAAPSCFFNGPLPKEISKLKH----LAKLDLSYNPLKCSIPKSFG- 255

  Fly   721 GKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSH 785
                     :|.:|:|.|.:...:...:|                ..:|:..|    ||.|.||.
plant   256 ---------ELHNLSILNLVSAELIGLIP----------------PELGNCKS----LKSLMLSF 291

  Fly   786 NEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHL 850
            |.:|  ..|| :..|:..||.:|              |.....|.|..|:..             
plant   292 NSLS--GPLP-LELSEIPLLTFS--------------AERNQLSGSLPSWMG------------- 326

  Fly   851 RLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLK-E 914
            :.:.|.:|:||:|..         :..:.:|.||.              |.|..|.:.:|.|. .
plant   327 KWKVLDSLLLANNRF---------SGEIPHEIEDC--------------PMLKHLSLASNLLSGS 368

  Fly   915 IPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVG 979
            ||..|....||..:::|||           |||                               |
plant   369 IPRELCGSGSLEAIDLSGN-----------LLS-------------------------------G 391

  Fly   980 YLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARS 1044
            .::.:::             |.:.:|:.    ||.....:||        ..|:.|         
plant   392 TIEEVFD-------------GCSSLGEL----LLTNNQINGS--------IPEDLW--------- 422

  Fly  1045 TSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRS 1109
                         .:..:.:|:.         :....|.:....|......|:.|::    ::..
plant   423 -------------KLPLMALDLD---------SNNFTGEIPKSLWKSTNLMEFTASY----NRLE 461

  Fly  1110 LYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFI 1174
            .||.           ||    :||                            |..|::|:     
plant   462 GYLP-----------AE----IGN----------------------------AASLKRLV----- 478

  Fly  1175 AIPDAEKIG-LPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALED 1238
             :.|.:..| :||.|..:    .:|..::|.||                 |...|||   :.|.|
plant   479 -LSDNQLTGEIPREIGKL----TSLSVLNLNAN-----------------MFQGKIP---VELGD 518

  Fly  1239 IVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDAT 1303
            ..::...:|.:..    |.|:...::..             .|:||     |    ::|.|::  
plant   519 CTSLTTLDLGSNN----LQGQIPDKITA-------------LAQLQ-----C----LVLSYNN-- 555

  Fly  1304 LRDYYFLDPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFE 1368
                           |:..:..:   |.|....:::.||..|    |..|..:.||     |:  
plant   556 ---------------LSGSIPSK---PSAYFHQIEMPDLSFL----QHHGIFDLSY-----NR-- 591

  Fly  1369 VALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLG-CSVSQEVNLNNLIYEQRSAPSS 1432
                       :...:|.:                     || |.|..|::|:|           
plant   592 -----------LSGPIPEE---------------------LGECLVLVEISLSN----------- 613

  Fly  1433 SSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDT 1497
            :..|..:...|.|:..:|..                              |.:...|..|:.::.
plant   614 NHLSGEIPASLSRLTNLTIL------------------------------DLSGNALTGSIPKEM 648

  Fly  1498 QWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKL-----KQDGIWSDVNLSSSSI 1557
            ..:|...||.|....:    ...:|       :.|...|:..||     |.||   .|..|..::
plant   649 GNSLKLQGLNLANNQL----NGHIP-------ESFGLLGSLVKLNLTKNKLDG---PVPASLGNL 699

  Fly  1558 LEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPS-LGT----RF 1617
            .|:          ..:|.:...|..|:...:|.:.||:.|.::......|  .|| ||.    .:
plant   700 KEL----------THMDLSFNNLSGELSSELSTMEKLVGLYIEQNKFTGE--IPSELGNLTQLEY 752

  Fly  1618 VHTSEGRF---LITRLVLCPRCLWKLQLQQNNEPSDREVPPVG-CNRPSRSSRRGAGAYFLHGVG 1678
            :..||...   :.|::...|. |..|.|.:||...  |||..| |..||::...|........||
plant   753 LDVSENLLSGEIPTKICGLPN-LEFLNLAKNNLRG--EVPSDGVCQDPSKALLSGNKELCGRVVG 814

  Fly  1679 -DPGEDGA--------------------LNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSA 1722
             |...:|.                    :.|||....|..:|.::.:|             |:..
plant   815 SDCKIEGTKLRSAWGIAGLMLGFTIIVFVFVFSLRRWAMTKRVKQRDD-------------PERM 866

  Fly  1723 GSSRNTSVDGHPGYHL-------PDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDV 1780
            ..||.........|.|       |.:.|:.   |.|:.:|.|                 :|. |:
plant   867 EESRLKGFVDQNLYFLSGSRSREPLSINIA---MFEQPLLKV-----------------RLG-DI 910

  Fly  1781 IFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESAL 1845
            :.|         ::...|.:::|.|.||.|:|| | :.|.   |.||:|.|      :.||....
plant   911 VEA---------TDHFSKKNIIGDGGFGTVYKA-C-LPGE---KTVAVKKL------SEAKTQGN 955

  Fly  1846 MAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGIC--IKPLALVLELAPLGGL 1908
            ..|..                      |:..|..:||||:|.|:|.|  .:...||.|....|.|
plant   956 REFMA----------------------EMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSL 998

  Fly  1909 DALLRHYRRSGAHMGPHTFQTLVLQ-------------AARAIEYLHR---RRIIYRDLKSENVL 1957
            |..||:             ||.:|:             |||.:.:||.   ..||:||:|:.|:|
plant   999 DHWLRN-------------QTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNIL 1050

  Fly  1958 VWELPQPHTEDSPRNLVHIKIADYGISRQTAPSG---AKGFGGTEGFMAPEIIRYNGEEEYTEKV 2019
            :....:|            |:||:|::|..:...   :....||.|::.||   |......|.|.
plant  1051 LDGDFEP------------KVADFGLARLISACESHVSTVIAGTFGYIPPE---YGQSARATTKG 1100

  Fly  2020 DCFSFGMFIYENISLRQP----FEGHE-------SIKEC-------ILEGSRPALTQRETQFPTC 2066
            |.:|||:.:.|.::.::|    |:..|       :|::.       :::....::..:.:|..  
plant  1101 DVYSFGVILLELVTGKEPTGPDFKESEGGNLVGWAIQKINQGKAVDVIDPLLVSVALKNSQLR-- 1163

  Fly  2067 CLDLMVLCWHEQPRRRPTASQIVSIL 2092
            .|.:.:||..|.|.:||....::..|
plant  1164 LLQIAMLCLAETPAKRPNMLDVLKAL 1189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566 8/35 (23%)
leucine-rich repeat 547..569 CDD:275380 4/21 (19%)
LRR_8 569..629 CDD:290566 26/62 (42%)
leucine-rich repeat 570..595 CDD:275380 6/25 (24%)
leucine-rich repeat 596..618 CDD:275380 9/23 (39%)
leucine-rich repeat 619..641 CDD:275380 10/22 (45%)
leucine-rich repeat 642..676 CDD:275380 9/35 (26%)
leucine-rich repeat 677..730 CDD:275380 12/54 (22%)
LRR_8 729..788 CDD:290566 13/58 (22%)
leucine-rich repeat 731..754 CDD:275380 5/22 (23%)
LRR_8 855..933 CDD:290566 19/78 (24%)
leucine-rich repeat 855..901 CDD:275380 8/45 (18%)
leucine-rich repeat 902..924 CDD:275380 7/22 (32%)
leucine-rich repeat 925..949 CDD:275380 7/23 (30%)
P-loop_NTPase 993..1211 CDD:304359 31/218 (14%)
COR 1230..1471 CDD:292713 35/241 (15%)
STYKc 1796..2092 CDD:214568 82/334 (25%)
STKc_LRRK 1801..2095 CDD:270902 82/331 (25%)
EMS1NP_196345.1 PLN00113 30..1190 CDD:215061 341/1707 (20%)
leucine-rich repeat 91..114 CDD:275380 7/29 (24%)
leucine-rich repeat 115..138 CDD:275380 6/25 (24%)
leucine-rich repeat 139..163 CDD:275380 9/23 (39%)
leucine-rich repeat 164..187 CDD:275380 12/28 (43%)
leucine-rich repeat 188..211 CDD:275380 5/22 (23%)
leucine-rich repeat 212..235 CDD:275380 6/22 (27%)
PLN03150 <224..307 CDD:178695 26/119 (22%)
leucine-rich repeat 236..259 CDD:275380 7/32 (22%)
leucine-rich repeat 260..283 CDD:275380 5/38 (13%)
leucine-rich repeat 284..303 CDD:275380 9/21 (43%)
leucine-rich repeat 333..350 CDD:275380 5/25 (20%)
leucine-rich repeat 355..378 CDD:275380 7/22 (32%)
leucine-rich repeat 379..402 CDD:275380 9/77 (12%)
leucine-rich repeat 403..424 CDD:275380 7/54 (13%)
leucine-rich repeat 426..449 CDD:275380 3/31 (10%)
leucine-rich repeat 450..473 CDD:275380 9/69 (13%)
leucine-rich repeat 474..497 CDD:275380 7/32 (22%)
leucine-rich repeat 498..521 CDD:275380 10/42 (24%)
leucine-rich repeat 522..545 CDD:275380 3/39 (8%)
leucine-rich repeat 546..578 CDD:275380 10/60 (17%)
leucine-rich repeat 579..604 CDD:275380 9/67 (13%)
leucine-rich repeat 606..629 CDD:275380 6/33 (18%)
leucine-rich repeat 630..646 CDD:275380 4/45 (9%)
leucine-rich repeat 654..677 CDD:275380 5/33 (15%)
leucine-rich repeat 678..701 CDD:275380 7/25 (28%)
leucine-rich repeat 702..725 CDD:275380 4/32 (13%)
leucine-rich repeat 726..749 CDD:275380 7/24 (29%)
leucine-rich repeat 750..773 CDD:275380 3/22 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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