DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT5G06940

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_196311.1	Gene:	AT5G06940 / 830585	AraportID:	AT5G06940	Length:	872	Species:	Arabidopsis thaliana

Alignment Length:	1086	Identity:	210/1086 - (19%)
Similarity:	363/1086 - (33%)	Gaps:	432/1086 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 ISYSAMFPNNP--TIIDWHSMGSS-----VQLSVVRVPWM-VSGVLLLNPKLQSHPRLNEVA--- 543
            :.:.|.| ::|  ::..|.:..||     ..::..|.|.: ||.:     .|||.....|::
plant    37 LRFKASF-DDPKGSLSGWFNTSSSHHCNWTGITCTRAPTLYVSSI-----NLQSLNLSGEISDSI 95

  Fly   544 --LTAITRIDFSHNVLTS-IPQELFHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQ 605
              |..:|.:|.|.|.... ||.:|...|:|..||::.|.|          :|
plant    96 CDLPYLTHLDLSLNFFNQPIPLQLSRCVTLETLNLSSNLI----------WG------------- 137

  Fly   606 LTTLPAAIFHLPALSILDVSNNKLQ-QLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSL 669
              |:|..|....:|.::|.|:|.:: .:|.||.....|:.||:..|||..:..|.:...|.|:.|
plant   138 --TIPDQISEFSSLKVIDFSSNHVEGMIPEDLGLLFNLQVLNLGSNLLTGIVPPAIGKLSELVVL 200

  Fly   670 DKLNLQSF--EEPPSNKPR-NVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQL 731
            | |:..|:  .|.||...: :..:|.|.||:.:.                  |:..|:.||.:.|
plant   201 D-LSENSYLVSEIPSFLGKLDKLEQLLLHRSGFH------------------GEIPTSFVGLTSL 246

  Fly   732 SSLNIA-NNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPA------------------- 776
            .:|::: |||...||.:|.....||..|::|.|.|..     |:|:
plant   247 RTLDLSLNNLSGEIPRSLGPSLKNLVSLDVSQNKLSG-----SFPSGICSGKRLINLSLHSNFFE 306

  Fly   777 -----------TLKQLDLSHNEIS------CWPSLPRI----------TESDPHLLCYSCV---- 810
                       :|::|.:.:|..|      .| .||||          |...|..:..:..
plant   307 GSLPNSIGECLSLERLQVQNNGFSGEFPVVLW-KLPRIKIIRADNNRFTGQVPESVSLASALEQV 370

  Fly   811 ---------QLPEGR---DDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADN 863
                     ::|.|.   ...||      .|:|...|...:..:.|
plant   371 EIVNNSFSGEIPHGLGLVKSLYK------FSASQNRFSGELPPNFC------------------- 410

  Fly   864 LLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVI--FPNLSMLDMTNNCLK------------- 913
                      |:..|         |:|.::.::::  .|.|      .||.|
plant   411 ----------DSPVL---------SIVNISHNRLLGKIPEL------KNCKKLVSLSLAGNAFTG 450

  Fly   914 EIPASLHELSSLSVLNISGNVNITELPPHLGLLS---RLWNLNTRGCLLQEPLRSMIESKKHKTM 975
            |||.||.:|..|:.|::|.| ::|.|.|. ||.:   .|:|::..|...:.|         |..
plant   451 EIPPSLADLHVLTYLDLSDN-SLTGLIPQ-GLQNLKLALFNVSFNGLSGEVP---------HSL- 503

  Fly   976 DIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQG----AGSGSSSSSHRSRASENHWA 1036
                                     |:|:..|.|     ||    .|.|..:|.
plant   504 -------------------------VSGLPASFL-----QGNPELCGPGLPNSC----------- 527

  Fly  1037 KRMGHARSTSRSHRHSSASSA---NISTVGVDIGTWIC----EKRKRAPGSHGPVVFR-TWDFGG 1093
                   |:.||:.|.....|   ::..:.:.|.|::.    ..||:       |.|: ||
plant   528 -------SSDRSNFHKKGGKALVLSLICLALAIATFLAVLYRYSRKK-------VQFKSTW---- 574

  Fly  1094 QKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESIS 1158
            :.|:|  :.:.|::..|..|                    :....|:...:.|
plant   575 RSEFY--YPFKLTEHELMKV--------------------VNESCPSGSEVYV------------ 605

  Fly  1159 PQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLH-NIHLLANIIYDTAMQLRSPGSKE 1222
                           :::...|.:.:.::::|..||.::|. .:..:|.|.:....::.....|:
plant   606 ---------------LSLSSGELLAVKKLVNSKNISSKSLKAQVRTIAKIRHKNITRILGFCFKD 655

  Fly  1223 PMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKS----------- 1276
            .|:       ::..|                           .|:...||:..|
plant   656 EMI-------FLIYE---------------------------FTQNGSLHDMLSRAGDQLPWSIR 686

  Fly  1277 FRDAAELQQATTWCHENGV--LLHYD--DATLRDYYFLDPQW---LCDM-LAHVVTVREINPFAP 1333
            .:.|..:.||..:..::.|  |||.:  .|.:    |||..:   |.|. |.|:|.
plant   687 LKIALGVAQALAYISKDYVPHLLHRNLKSANI----FLDKDFEPKLSDFALDHIVG--------- 738

  Fly  1334 TGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWD----SRTLLIPSLLPSQEAATPNS 1394
                     :..|:|: |..|.|..| .:..|.:....|.|    |..:::..|:..|.|.....
plant   739 ---------ETAFQSL-VHANTNSCY-TAPENHYSKKATEDMDVYSFGVVLLELVTGQSAEKAEE 792

  Fly  1395 GSTVKLSQRSRGRSLGC--SVSQEVNLNN---LIYEQRSAPSSSSS 1435
            ||:        |.||..  .|.:::||.:   .:.:|:....|..|
plant   793 GSS--------GESLDIVKQVRRKINLTDGAAQVLDQKILSDSCQS 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566	13/36 (36%)
		leucine-rich repeat	547..569	CDD:275380	7/22 (32%)
		LRR_8	569..629	CDD:290566	13/59 (22%)
		leucine-rich repeat	570..595	CDD:275380	6/24 (25%)
		leucine-rich repeat	596..618	CDD:275380	3/21 (14%)
		leucine-rich repeat	619..641	CDD:275380	7/22 (32%)
		leucine-rich repeat	642..676	CDD:275380	12/33 (36%)
		leucine-rich repeat	677..730	CDD:275380	11/55 (20%)
		LRR_8	729..788	CDD:290566	19/89 (21%)
		leucine-rich repeat	731..754	CDD:275380	8/23 (35%)
		LRR_8	855..933	CDD:290566	18/92 (20%)
		leucine-rich repeat	855..901	CDD:275380	4/47 (9%)
		leucine-rich repeat	902..924	CDD:275380	10/34 (29%)
		leucine-rich repeat	925..949	CDD:275380	9/26 (35%)
		P-loop_NTPase	993..1211	CDD:304359	36/230 (16%)
		COR	1230..1471	CDD:292713	45/234 (19%)
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
AT5G06940	NP_196311.1	LRRNT_2	30..70	CDD:285463	6/33 (18%)
		PLN00113	31..868	CDD:215061	210/1086 (19%)
		LRR_RI	81..332	CDD:238064	73/299 (24%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		leucine-rich repeat	125..148	CDD:275380	9/47 (19%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		leucine-rich repeat	197..221	CDD:275380	8/24 (33%)
		leucine-rich repeat	222..245	CDD:275380	8/40 (20%)
		leucine-rich repeat	246..270	CDD:275380	8/23 (35%)
		LRR_RI	248..>487	CDD:238064	58/296 (20%)
		leucine-rich repeat	271..294	CDD:275380	7/27 (26%)
		leucine-rich repeat	295..318	CDD:275380	0/22 (0%)
		leucine-rich repeat	319..342	CDD:275380	6/23 (26%)
		leucine-rich repeat	367..390	CDD:275380	2/22 (9%)
		leucine-rich repeat	391..411	CDD:275380	6/54 (11%)
		leucine-rich repeat	415..437	CDD:275380	7/36 (19%)
		leucine-rich repeat	438..461	CDD:275380	6/22 (27%)
		leucine-rich repeat	462..483	CDD:275380	9/22 (41%)
		PKc_like	601..863	CDD:304357	55/323 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050