DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT4G28650

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_194594.1	Gene:	AT4G28650 / 828983	AraportID:	AT4G28650	Length:	1013	Species:	Arabidopsis thaliana

Alignment Length:	832	Identity:	188/832 - (22%)
Similarity:	301/832 - (36%)	Gaps:	231/832 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   560 IPQELFHLVSLRYLNVAQNKIT-DLPAPIGQTYGCPVLDELFLQDNQLT-TLPAAIFHLPALSIL 622
            ||.|..::.||:||::|..|:: ::|:.:|:...   |:.|.|.:|..| |:|..|..:..|.:|
plant   228 IPPEFGNINSLKYLDLAIGKLSGEIPSELGKLKS---LETLLLYENNFTGTIPREIGSITTLKVL 289

  Fly   623 DVSNNKLQ-QLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQS---FEEPPSN 683
            |.|:|.|. ::|.::.:...|:.||:..|.|.. .:||  ..|||..|..|.|.:   ..|.||:
plant   290 DFSDNALTGEIPMEITKLKNLQLLNLMRNKLSG-SIPP--AISSLAQLQVLELWNNTLSGELPSD 351

  Fly   684 KPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFT-SIPAA 747
            ..:|...|       |   ||::.|...       |:..:.......|:.|.:.||.|| .|||.
plant   352 LGKNSPLQ-------W---LDVSSNSFS-------GEIPSTLCNKGNLTKLILFNNTFTGQIPAT 399

  Fly   748 LPCLAVNLTRLNMSYNSLRSMGHVTSYP------ATLKQLDLSHNEISCWPSLPRITESDPHLLC 806
            | ....:|.|:.|..|.|..     |.|      ..|::|:|:.|.:|  ..:|
plant   400 L-STCQSLVRVRMQNNLLNG-----SIPIGFGKLEKLQRLELAGNRLS--GGIP----------- 445

  Fly   807 YSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLT-RIQL 870
                      .|...:.|......|....|:|:..::      |.:..|:..::|||.:: .:..
plant   446 ----------GDISDSVSLSFIDFSRNQIRSSLPSTI------LSIHNLQAFLVADNFISGEVPD 494

  Fly   871 STDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLK-EIPASLHELSSLSVLNISGNV 934
            ...|..:|.|....::.....:..|......|..|::.||.|. |||..:..:|:|:||::|.|.
plant   495 QFQDCPSLSNLDLSSNTLTGTIPSSIASCEKLVSLNLRNNNLTGEIPRQITTMSALAVLDLSNNS 559

  Fly   935 NITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVV 999
            ....||..:|....|..||.....|..|            :.|.|:||:|..|.         :.
plant   560 LTGVLPESIGTSPALELLNVSYNKLTGP------------VPINGFLKTINPDD---------LR 603

  Fly  1000 GVAGIGKSTLLDLLRQGAGSGSSSSSHRSR----------------------------------- 1029
            |.:|:....|....:....:.|.||.|..|
plant   604 GNSGLCGGVLPPCSKFQRATSSHSSLHGKRIVAGWLIGIASVLALGILTIVTRTLYKKWYSNGFC 668

  Fly  1030 ----ASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWD 1090
                ||:..|..|:      ...||....:|        ||...|.|......|:.| :|::.
plant   669 GDETASKGEWPWRL------MAFHRLGFTAS--------DILACIKESNMIGMGATG-IVYKA-- 716

  Fly  1091 FGGQKEYYATHQYFLSKRSLYLV---LWR----ISDG----------------HKGLAELLQWLG 1132
                         .:|:.|..|.   |||    |.||                |:.:..||.:|.
plant   717 -------------EMSRSSTVLAVKKLWRSAADIEDGTTGDFVGEVNLLGKLRHRNIVRLLGFLY 768

  Fly  1133 NIQARAPNSPVIIVGTHFDAVGESISPQKA--EQLQQLIREKFIAIPDAEKIGLPRVIDSIEISC 1195
            |.:    |..::........:|::|..:.|  ..|...:....||      :|:...:..:...|
plant   769 NDK----NMMIVYEFMLNGNLGDAIHGKNAAGRLLVDWVSRYNIA------LGVAHGLAYLHHDC 823

  Fly  1196 R--TLH------NIHLLANI---IYDTAMQLRSPGSKEPMLLQKIPASYIALE-----------D 1238
            .  .:|      ||.|.||:   |.|..:.......||.:.:......|||.|           |
plant   824 HPPVIHRDIKSNNILLDANLDARIADFGLARMMARKKETVSMVAGSYGYIAPEYGYTLKVDEKID 888

  Fly  1239 IVN--VIACNLRAAGRDPVLD--GEQYKRLVTEQMRLHNYKSFRDAAELQQA 1286
            |.:  |:...| ..||.|:..  ||...  :.|.:|    :..||...|::|
plant   889 IYSYGVVLLEL-LTGRRPLEPEFGESVD--IVEWVR----RKIRDNISLEEA 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566	8/19 (42%)
		leucine-rich repeat	547..569	CDD:275380	3/8 (38%)
		LRR_8	569..629	CDD:290566	21/61 (34%)
		leucine-rich repeat	570..595	CDD:275380	7/25 (28%)
		leucine-rich repeat	596..618	CDD:275380	8/22 (36%)
		leucine-rich repeat	619..641	CDD:275380	7/22 (32%)
		leucine-rich repeat	642..676	CDD:275380	13/33 (39%)
		leucine-rich repeat	677..730	CDD:275380	10/52 (19%)
		LRR_8	729..788	CDD:290566	21/65 (32%)
		leucine-rich repeat	731..754	CDD:275380	10/23 (43%)
		LRR_8	855..933	CDD:290566	21/79 (27%)
		leucine-rich repeat	855..901	CDD:275380	8/46 (17%)
		leucine-rich repeat	902..924	CDD:275380	8/22 (36%)
		leucine-rich repeat	925..949	CDD:275380	8/23 (35%)
		P-loop_NTPase	993..1211	CDD:304359	52/292 (18%)
		COR	1230..1471	CDD:292713	19/72 (26%)
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
AT4G28650	NP_194594.1	PLN00113	27..986	CDD:215061	188/832 (23%)
		leucine-rich repeat	73..96	CDD:275380
		leucine-rich repeat	97..117	CDD:275380
		leucine-rich repeat	118..141	CDD:275380
		leucine-rich repeat	142..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380
		leucine-rich repeat	190..213	CDD:275380
		leucine-rich repeat	214..237	CDD:275380	3/8 (38%)
		leucine-rich repeat	238..261	CDD:275380	7/22 (32%)
		leucine-rich repeat	262..285	CDD:275380	8/22 (36%)
		leucine-rich repeat	286..333	CDD:275380	17/49 (35%)
		leucine-rich repeat	334..354	CDD:275380	6/19 (32%)
		leucine-rich repeat	358..381	CDD:275380	6/39 (15%)
		leucine-rich repeat	382..405	CDD:275380	10/23 (43%)
		leucine-rich repeat	406..429	CDD:275380	7/27 (26%)
		leucine-rich repeat	430..453	CDD:275380	7/45 (16%)
		leucine-rich repeat	454..501	CDD:275380	9/52 (17%)
		leucine-rich repeat	502..525	CDD:275380	3/22 (14%)
		leucine-rich repeat	526..549	CDD:275380	8/22 (36%)
		leucine-rich repeat	550..573	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050