DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and HAE

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_194578.1	Gene:	HAE / 828967	AraportID:	AT4G28490	Length:	999	Species:	Arabidopsis thaliana

Alignment Length:	1123	Identity:	229/1123 - (20%)
Similarity:	399/1123 - (35%)	Gaps:	345/1123 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1123 GLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRV 1187
            ||::..|.|.:.......:|...:|...||....:|                  .|.....|...
plant    34 GLSDPAQSLSSWSDNNDVTPCKWLGVSCDATSNVVS------------------VDLSSFMLVGP 80

  Fly  1188 IDSIEISCRTLHNIHLLANII--------YDTAMQLRSPGSKEPMLLQKIPASY-IALEDI--VN 1241
            ..||.....:||::.|..|.|        :||...|.|....|.:|:..||.|. ..|.::  :.
plant    81 FPSILCHLPSLHSLSLYNNSINGSLSADDFDTCHNLISLDLSENLLVGSIPKSLPFNLPNLKFLE 145

  Fly  1242 VIACNLRAAGRDPVLDGEQYKRLVTEQMRL-HNYKSFRDAAELQQATTWCHENGVLLHYD----- 1300
            :...||  :...|...|| :::|  |.:.| .|:.|....|.|...||.   ..:.|.|:
plant   146 ISGNNL--SDTIPSSFGE-FRKL--ESLNLAGNFLSGTIPASLGNVTTL---KELKLAYNLFSPS 202

  Fly  1301 --DATLRDYYFLDPQWL--CDMLAHV--------------VTVREINPFAPTGVMKLDDLQML-- 1345
              .:.|.:...|...||  |:::..:              :|..::....|:.:.:|..::.:
plant   203 QIPSQLGNLTELQVLWLAGCNLVGPIPPSLSRLTSLVNLDLTFNQLTGSIPSWITQLKTVEQIEL 267

  Fly  1346 ----FRSVQVQGNGNRSYI----------------------VSLLNKFEVALTWD-------SRT 1377
                |.....:..||.:.:                      :..||.||..|...       |:|
plant   268 FNNSFSGELPESMGNMTTLKRFDASMNKLTGKIPDNLNLLNLESLNLFENMLEGPLPESITRSKT 332

  Fly  1378 L--------LIPSLLPSQEAATPNSG-STVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSS 1433
            |        .:..:||||..|  ||. ..|.||.......:..:|..|..|..||....|.....
plant   333 LSELKLFNNRLTGVLPSQLGA--NSPLQYVDLSYNRFSGEIPANVCGEGKLEYLILIDNSFSGEI 395

  Fly  1434 SSSASVSQGLRRILLMT-----YFPSGFWS--RLITRILADEQIIEAIRGVYMASQDYADFDLRT 1491
            |::....:.|.|:.|..     ..|.|||.  ||....|:|.....:|....:.:::.:  :||.
plant   396 SNNLGKCKSLTRVRLSNNKLSGQIPHGFWGLPRLSLLELSDNSFTGSIPKTIIGAKNLS--NLRI 458

  Fly  1492 SLEQDTQWNLWQTGLALYYGPIL-IFKI--------WEVPFQKTERTQPFRTDGNRFKLKQD--- 1544
            |.      |.:...:....|.:. |.:|        .|:|....:..|..|.|.::.:|..:
plant   459 SK------NRFSGSIPNEIGSLNGIIEISGAENDFSGEIPESLVKLKQLSRLDLSKNQLSGEIPR 517

  Fly  1545 ---GIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMS-QVAKLLAL--TVDHID 1603
               | |.::|              |:|::..              |:| ::.|.:.:  .::::|
plant   518 ELRG-WKNLN--------------ELNLANN--------------HLSGEIPKEVGILPVLNYLD 553

  Fly  1604 LLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDR---EVPPVGCNRPSRSS 1665
            |....:...:                    |..|..|:|...|...:.   ::||:..|:
plant   554 LSSNQFSGEI--------------------PLELQNLKLNVLNLSYNHLSGKIPPLYANK----- 593

  Fly  1666 RRGAGAYFLHG-VGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTS 1729
                  .:.|. :|:||       ....|:...|:..||:
plant   594 ------IYAHDFIGNPG-------LCVDLDGLCRKITRSK------------------------- 620

  Fly  1730 VDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQ-----------LAPD---- 1779
                         |:.|.|:    :|:::..:.:...|.:...:|:           ||..
plant   621 -------------NIGYVWI----LLTIFLLAGLVFVVGIVMFIAKCRKLRALKSSTLAASKWRS 668

  Fly  1780 ---VIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAK 1841
               :.|::    |.| ::|:.:.:::|.|:.|.|:|.  ::||.   :.||:|.|.....|...:
plant   669 FHKLHFSE----HEI-ADCLDEKNVIGFGSSGKVYKV--ELRGG---EVVAVKKLNKSVKGGDDE 723

  Fly  1842 ESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAP 1904
            .|:             |.|.....|     .|:..|.|::|.:||.|...|...  ..||.|..|
plant   724 YSS-------------DSLNRDVFA-----AEVETLGTIRHKSIVRLWCCCSSGDCKLLVYEYMP 770

  Fly  1905 LGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHR---RRIIYRDLKSENVLVWELPQPHT 1966
            .|.|..:|...|:.|..:|......:.|.||..:.|||.   ..|::||:||.|:|:
plant   771 NGSLADVLHGDRKGGVVLGWPERLRIALDAAEGLSYLHHDCVPPIVHRDVKSSNILL-------- 827

  Fly  1967 EDSPRNLVHIKIADYGISRQTAPSGAK------GFGGTEGFMAPEIIRYNGEEEYT----EKVDC 2021
             ||...   .|:||:||::....||:|      |..|:.|::|||.:       ||    ||.|.
plant   828 -DSDYG---AKVADFGIAKVGQMSGSKTPEAMSGIAGSCGYIAPEYV-------YTLRVNEKSDI 881

  Fly  2022 FSFGMFIYENISLRQPFEGH-----------ESIKECILEG-SRPALTQRETQFPTCCLDLMVLC 2074
            :|||:.:.|.::.:||.:..           .::.:|.||. ..|.|..:..:..:..:.:.:||
plant   882 YSFGVVLLELVTGKQPTDSELGDKDMAKWVCTALDKCGLEPVIDPKLDLKFKEEISKVIHIGLLC 946

  Fly  2075 WHEQPRRRPTASQIVSIL 2092
            ....|..||:..::|.:|
plant   947 TSPLPLNRPSMRKVVIML 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359	18/95 (19%)
		COR	1230..1471	CDD:292713	66/318 (21%)
		STYKc	1796..2092	CDD:214568	85/322 (26%)
		STKc_LRRK	1801..2095	CDD:270902	86/319 (27%)
HAE	NP_194578.1	LRRNT_2	21..62	CDD:285463	6/27 (22%)
		PLN00113	32..968	CDD:215061	229/1123 (20%)
		leucine-rich repeat	91..115	CDD:275380	7/23 (30%)
		leucine-rich repeat	116..140	CDD:275380	8/23 (35%)
		leucine-rich repeat	141..164	CDD:275380	5/25 (20%)
		leucine-rich repeat	165..188	CDD:275380	7/24 (29%)
		leucine-rich repeat	189..213	CDD:275380	3/26 (12%)
		leucine-rich repeat	214..237	CDD:275380	4/22 (18%)
		leucine-rich repeat	238..261	CDD:275380	3/22 (14%)
		leucine-rich repeat	262..285	CDD:275380	3/22 (14%)
		leucine-rich repeat	286..332	CDD:275380	6/45 (13%)
		leucine-rich repeat	333..351	CDD:275380	4/17 (24%)
		leucine-rich repeat	357..380	CDD:275380	5/22 (23%)
		leucine-rich repeat	381..404	CDD:275380	5/22 (23%)
		leucine-rich repeat	405..428	CDD:275380	7/22 (32%)
		leucine-rich repeat	429..452	CDD:275380	4/22 (18%)
		leucine-rich repeat	453..476	CDD:275380	5/30 (17%)
		leucine-rich repeat	477..500	CDD:275380	4/22 (18%)
		leucine-rich repeat	501..548	CDD:275380	11/75 (15%)
		leucine-rich repeat	549..571	CDD:275380	4/41 (10%)
		leucine-rich repeat	572..592	CDD:275380	4/19 (21%)
		PKc_like	689..967	CDD:304357	86/318 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050