DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and IMK2

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_190742.1	Gene:	IMK2 / 824337	AraportID:	AT3G51740	Length:	836	Species:	Arabidopsis thaliana

Alignment Length:	1044	Identity:	207/1044 - (19%)
Similarity:	349/1044 - (33%)	Gaps:	416/1044 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 SYSAMFPNNPTIID-------WHSMGSSV-------------QLSVVRVPWMVSGVLLLNPKLQS 535
            :|.|:......:||       |::..||.             |:..:::||...|. .::.|:..
plant    53 NYQALQAIKHELIDFTGVLKSWNNSASSQVCSGWAGIKCLRGQVVAIQLPWKGLGG-TISEKIGQ 116

  Fly   536 HPRLNEVALTAITRIDFSHNVLT-SIPQELFHLVSLRYLNVAQNKIT-DLPAPIGQTYGCPVLDE 598
                    |.::.::...:||:. |:|:.|.:|.|||.:.:..|::: .:|..:|   .||:|..
plant   117 --------LGSLRKLSLHNNVIAGSVPRSLGYLKSLRGVYLFNNRLSGSIPVSLG---NCPLLQN 170

  Fly   599 LFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNVAFNLLRDLPVP-PMQT 662
            |.|..||||                      ..:|..|..:.:|..||::||.|.. |:| .:..
plant   171 LDLSSNQLT----------------------GAIPPSLTESTRLYRLNLSFNSLSG-PLPVSVAR 212

  Fly   663 SSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVG 727
            |.:|..||                      |.|.||..:..|...|                  |
plant   213 SYTLTFLD----------------------LQHNNLSGSIPDFFVN------------------G 237

  Fly   728 SSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWP 792
            |..|.:||:.:|.|:   .|:|        :::..:||            |:::.:|||::|  .
plant   238 SHPLKTLNLDHNRFS---GAVP--------VSLCKHSL------------LEEVSISHNQLS--G 277

  Fly   793 SLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRT 857
            |:||           .|..||..:..|:...|..|:...:.|..:|::.        |.||
plant   278 SIPR-----------ECGGLPHLQSLDFSYNSINGTIPDSFSNLSSLVS--------LNLE---- 319

  Fly   858 LILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFP------NLS---MLDMT-NNCL 912
               :::|...|   .|....|.|.:|      :.:.|:|:..|      |:|   .||:: ||..
plant   320 ---SNHLKGPI---PDAIDRLHNLTE------LNLKRNKINGPIPETIGNISGIKKLDLSENNFT 372

  Fly   913 KEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNL-----NTRGC--------------- 957
            ..||.||..|:.||..|:|.|.....:||   :||:.:|.     |.:.|
plant   373 GPIPLSLVHLAKLSSFNVSYNTLSGPVPP---VLSKKFNSSSFLGNIQLCGYSSSNPCPAPDHHH 434

  Fly   958 -LLQEPLRSMIESKKH-----KTMDI----VGYLKSI--------------------YEDAQPYA 992
             |...|..|. |.:||     ...|:    :|.|.:|                    .:|.:...
plant   435 PLTLSPTSSQ-EPRKHHHRKLSVKDVILIAIGALLAILLLLCCILLCCLIKKRAALKQKDGKDKT 498

  Fly   993 RMKLMVVGVAGIGKS-----------------TLLDLLRQGAGSGSSSSSHRSRASENHWAKRMG 1040
            ..|.:..||||...:                 |..|||..                   .|:.||
plant   499 SEKTVSAGVAGTASAGGEMGGKLVHFDGPFVFTADDLLCA-------------------TAEIMG 544

  Fly  1041 HARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYA--THQY 1103
              :||     :.:|..|.:     :.|..:..||.|...:.|     ..:|.|:.....  .||.
plant   545 --KST-----YGTAYKATL-----EDGNEVAVKRLREKTTKG-----VKEFEGEVTALGKIRHQN 592

  Fly  1104 FLSKRSLYLVLWRISDGHKGLAELL-QWLGN------IQARAPNSPVIIVGTHFDAVGESISPQK 1161
            .|:.|:.||       |.||...|: .::..      :.||.|.:
plant   593 LLALRAYYL-------GPKGEKLLVFDYMSKGSLSAFLHARGPET-------------------- 630

  Fly  1162 AEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLL 1226
                         .||...::.:.:.|.      |.|.::|                 |.|.|:.
plant   631 -------------LIPWETRMKIAKGIS------RGLAHLH-----------------SNENMIH 659

  Fly  1227 QKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLV----TEQMRLHNYKSFRDAAELQQAT 1287
            :.:.||.|.|::..|   .::...|...::.......::    |...|...:...::|:    |.
plant   660 ENLTASNILLDEQTN---AHIADYGLSRLMTAAAATNVIATAGTLGYRAPEFSKIKNAS----AK 717

  Fly  1288 TWCHENGVLLHYDDATLRDYYFLD----------------PQWLCDMLAHVVTVREINPFAPTGV 1336
            |..:..|:::            |:                |||    :|.:|.....|
plant   718 TDVYSLGIII------------LELLTGKSPGEPTNGMDLPQW----VASIVKEEWTN------- 759

  Fly  1337 MKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLS 1401
             ::.||: |.|..|..|:       .|||..::||          ..:....||.|.:...|:..
plant   760 -EVFDLE-LMRETQSVGD-------ELLNTLKLAL----------HCVDPSPAARPEANQVVEQL 805

  Fly  1402 QRSR 1405
            :..|
plant   806 EEIR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566	11/36 (31%)
		leucine-rich repeat	547..569	CDD:275380	6/22 (27%)
		LRR_8	569..629	CDD:290566	15/60 (25%)
		leucine-rich repeat	570..595	CDD:275380	6/25 (24%)
		leucine-rich repeat	596..618	CDD:275380	7/21 (33%)
		leucine-rich repeat	619..641	CDD:275380	2/21 (10%)
		leucine-rich repeat	642..676	CDD:275380	12/34 (35%)
		leucine-rich repeat	677..730	CDD:275380	8/52 (15%)
		LRR_8	729..788	CDD:290566	13/58 (22%)
		leucine-rich repeat	731..754	CDD:275380	7/22 (32%)
		LRR_8	855..933	CDD:290566	24/87 (28%)
		leucine-rich repeat	855..901	CDD:275380	9/51 (18%)
		leucine-rich repeat	902..924	CDD:275380	10/25 (40%)
		leucine-rich repeat	925..949	CDD:275380	9/23 (39%)
		P-loop_NTPase	993..1211	CDD:304359	42/243 (17%)
		COR	1230..1471	CDD:292713	35/196 (18%)
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
IMK2	NP_190742.1	LRRNT_2	55..91	CDD:285463	6/35 (17%)
		LRR_8	119..178	CDD:290566	18/61 (30%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	6/25 (24%)
		LRR_RI	166..372	CDD:238064	73/328 (22%)
		leucine-rich repeat	168..191	CDD:275380	9/44 (20%)
		leucine-rich repeat	192..215	CDD:275380	9/23 (39%)
		LRR_8	215..275	CDD:290566	24/122 (20%)
		leucine-rich repeat	216..240	CDD:275380	11/63 (17%)
		leucine-rich repeat	241..264	CDD:275380	7/33 (21%)
		leucine-rich repeat	265..288	CDD:275380	10/35 (29%)
		LRR_8	287..347	CDD:290566	16/83 (19%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		leucine-rich repeat	313..336	CDD:275380	7/40 (18%)
		LRR_8	336..393	CDD:290566	20/62 (32%)
		leucine-rich repeat	337..360	CDD:275380	5/28 (18%)
		leucine-rich repeat	361..382	CDD:275380	8/20 (40%)
		Pkinase	541..803	CDD:278497	68/390 (17%)
		STKc_IRAK	543..808	CDD:270968	69/393 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050