DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and BAM2

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_190536.1 Gene:BAM2 / 824129 AraportID:AT3G49670 Length:1002 Species:Arabidopsis thaliana


Alignment Length:1716 Identity:291/1716 - (16%)
Similarity:497/1716 - (28%) Gaps:831/1716 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   452 ILSRLLARRVHPDSDYKINKKGLPTPV-EVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLS 515
            :|..||...:|....:.:.|     |: |::..|...|:.:..   .::|.:..|:       ||
plant     4 LLLLLLLLLLHISHSFTVAK-----PITELHALLSLKSSFTID---EHSPLLTSWN-------LS 53

  Fly   516 VVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSH-NVLTSIPQELFHLVSLRYLNVAQNK 579
            .....|  :||..            :|:|..:|.:|.|. |:..::..::.||..|:.|::|.|:
plant    54 TTFCSW--TGVTC------------DVSLRHVTSLDLSGLNLSGTLSSDVAHLPLLQNLSLAANQ 104

  Fly   580 ITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRE 644
            |:   .||                      |..|.:|..|..|::|||                .
plant   105 IS---GPI----------------------PPQISNLYELRHLNLSNN----------------V 128

  Fly   645 LNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDND 709
            .|.:|         |.:.||.|::|                               ..||:.:|:
plant   129 FNGSF---------PDELSSGLVNL-------------------------------RVLDLYNNN 153

  Fly   710 MKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFT-SIPAALPCLAVNLTRLNMSYNSLR-----SM 768
            :       .||...:....:||..|::..|.|: .|||......| |..|.:|.|.|.     .:
plant   154 L-------TGDLPVSLTNLTQLRHLHLGGNYFSGKIPATYGTWPV-LEYLAVSGNELTGKIPPEI 210

  Fly   769 GHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQ--LPEGRDDDYKTASSKGSSSS 831
            |::|    ||::|.:.:                     |:..:  ||          ...|:.|.
plant   211 GNLT----TLRELYIGY---------------------YNAFENGLP----------PEIGNLSE 240

  Fly   832 ATSFRASVLKSVCRHRRHL-----RLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVG 891
            ...|.|    :.|.....:     :|:.|.||.|..|..|..                       
plant   241 LVRFDA----ANCGLTGEIPPEIGKLQKLDTLFLQVNAFTGT----------------------- 278

  Fly   892 VNRSKVIFPNLSMLDMTNNCLK-EIPASLHELSSLSVLNISGNVNITELPPHLGLLS-----RLW 950
            :.:...:..:|..:|::||... |||.|..:|.:|::||:..|.....:|..:|.:.     :||
plant   279 ITQELGLISSLKSMDLSNNMFTGEIPTSFSQLKNLTLLNLFRNKLYGAIPEFIGEMPELEVLQLW 343

  Fly   951 NLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQ 1015
            ..|..|.:.|:                                       :...|:..:|||   
plant   344 ENNFTGSIPQK---------------------------------------LGENGRLVILDL--- 366

  Fly  1016 GAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGS 1080
                                                    |:|                 :..|:
plant   367 ----------------------------------------SSN-----------------KLTGT 374

  Fly  1081 HGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVII 1145
            ..|                                .:..|:: |..|:. |||          .:
plant   375 LPP--------------------------------NMCSGNR-LMTLIT-LGN----------FL 395

  Fly  1146 VGTHFDAVGESISPQKAEQLQQL-IREKFI--AIPDAEKIGLPRVIDSIEISCRTLHNIHLLANI 1207
            .|:..|::|      |.|.|.:: :.|.|:  :|| .|..|||: :..:|:              
plant   396 FGSIPDSLG------KCESLTRIRMGENFLNGSIP-KELFGLPK-LSQVEL-------------- 438

  Fly  1208 IYDTAMQLRSPGSKEPMLLQKIPASYIALE-DIVNVIACNLRAAGRDP------------VLDGE 1259
                         ::..|..::|.|...:. |:..:...|.:.:|..|            :|||.
plant   439 -------------QDNYLTGELPISGGGVSGDLGQISLSNNQLSGSLPAAIGNLSGVQKLLLDGN 490

  Fly  1260 QYKRLVTEQM-RL---------HNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQW 1314
            ::...:..:: ||         ||..|.|.|.|:.:                             
plant   491 KFSGSIPPEIGRLQQLSKLDFSHNLFSGRIAPEISR----------------------------- 526

  Fly  1315 LCDMLAHV-VTVREINPFAP---TGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDS 1375
             |.:|..| ::..|::...|   ||:..|:.|           |.:|:::|.             
plant   527 -CKLLTFVDLSRNELSGDIPNELTGMKILNYL-----------NLSRNHLVG------------- 566

  Fly  1376 RTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVS 1440
               .||..:.|.::.|     :|..|..              ||:.|:      ||:...|    
plant   567 ---SIPVTIASMQSLT-----SVDFSYN--------------NLSGLV------PSTGQFS---- 599

  Fly  1441 QGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTG 1505
                      ||                              :|..|                .|
plant   600 ----------YF------------------------------NYTSF----------------VG 608

  Fly  1506 LALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNIS 1570
            .:...||.|      .|..|                                             
plant   609 NSHLCGPYL------GPCGK--------------------------------------------- 622

  Fly  1571 QEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPR 1635
                          ..|.|.|..|.|.|    .||                    |:..|:.|..
plant   623 --------------GTHQSHVKPLSATT----KLL--------------------LVLGLLFCSM 649

  Fly  1636 CLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRE 1700
                                                                ||:......||..
plant   650 ----------------------------------------------------VFAIVAIIKARSL 662

  Fly  1701 RRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISC 1765
            |                                       |::...||.     |:.:.:...:|
plant   663 R---------------------------------------NASEAKAWR-----LTAFQRLDFTC 683

  Fly  1766 PVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKM 1830
                        .||:            :.:.:.:::|:|..|.|:|.... :|    ..||:|.
plant   684 ------------DDVL------------DSLKEDNIIGKGGAGIVYKGTMP-KG----DLVAVKR 719

  Fly  1831 LQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI-- 1893
            |..:..|:..                    .|...|      |:..|..::|.:||.|:|.|.  
plant   720 LATMSHGSSH--------------------DHGFNA------EIQTLGRIRHRHIVRLLGFCSNH 758

  Fly  1894 KPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHR---RRIIYRDLKSEN 1955
            :...||.|..|.|.|..:|  :.:.|.|:..:|...:.|:||:.:.|||.   ..|::||:||.|
plant   759 ETNLLVYEYMPNGSLGEVL--HGKKGGHLHWNTRYKIALEAAKGLCYLHHDCSPLIVHRDVKSNN 821

  Fly  1956 VLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGA----KGFGGTEGFMAPEIIRYNGEEEYT 2016
            :|:....:.|            :||:|:::....||.    ....|:.|::|||   |....:..
plant   822 ILLDSNFEAH------------VADFGLAKFLQDSGTSECMSAIAGSYGYIAPE---YAYTLKVD 871

  Fly  2017 EKVDCFSFGMFIYENISLRQPF----EG----------HESIKECILEGSRPALTQRETQFPTCC 2067
            ||.|.:|||:.:.|.|:.::|.    :|          .:|.|:|:|:.....|:.......|..
plant   872 EKSDVYSFGVVLLELITGKKPVGEFGDGVDIVQWVRSMTDSNKDCVLKVIDLRLSSVPVHEVTHV 936

  Fly  2068 LDLMVLCWHEQPRRRPTASQIVSILS 2093
            ..:.:||..||...|||..::|.||:
plant   937 FYVALLCVEEQAVERPTMREVVQILT 962

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125 5/24 (21%)
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560 4/11 (36%)
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786 4/11 (36%)
LRR_8 <544..580 CDD:290566 11/36 (31%)
leucine-rich repeat 547..569 CDD:275380 6/22 (27%)
LRR_8 569..629 CDD:290566 15/59 (25%)
leucine-rich repeat 570..595 CDD:275380 7/24 (29%)
leucine-rich repeat 596..618 CDD:275380 3/21 (14%)
leucine-rich repeat 619..641 CDD:275380 5/21 (24%)
leucine-rich repeat 642..676 CDD:275380 7/33 (21%)
leucine-rich repeat 677..730 CDD:275380 5/52 (10%)
LRR_8 729..788 CDD:290566 19/64 (30%)
leucine-rich repeat 731..754 CDD:275380 7/23 (30%)
LRR_8 855..933 CDD:290566 18/78 (23%)
leucine-rich repeat 855..901 CDD:275380 6/45 (13%)
leucine-rich repeat 902..924 CDD:275380 9/22 (41%)
leucine-rich repeat 925..949 CDD:275380 6/28 (21%)
P-loop_NTPase 993..1211 CDD:304359 29/220 (13%)
COR 1230..1471 CDD:292713 43/267 (16%)
STYKc 1796..2092 CDD:214568 80/318 (25%)
STKc_LRRK 1801..2095 CDD:270902 82/316 (26%)
BAM2NP_190536.1 PLN00113 27..961 CDD:215061 283/1685 (17%)
leucine-rich repeat 71..94 CDD:275380 6/22 (27%)
leucine-rich repeat 95..118 CDD:275380 10/47 (21%)
leucine-rich repeat 119..143 CDD:275380 11/48 (23%)
leucine-rich repeat 144..167 CDD:275380 6/60 (10%)
leucine-rich repeat 168..191 CDD:275380 7/22 (32%)
leucine-rich repeat 192..215 CDD:275380 7/26 (27%)
leucine-rich repeat 216..240 CDD:275380 6/54 (11%)
leucine-rich repeat 241..288 CDD:275380 10/73 (14%)
leucine-rich repeat 289..310 CDD:275380 8/20 (40%)
leucine-rich repeat 313..336 CDD:275380 6/22 (27%)
leucine-rich repeat 337..360 CDD:275380 5/61 (8%)
leucine-rich repeat 361..381 CDD:275380 7/111 (6%)
leucine-rich repeat 385..405 CDD:275380 8/36 (22%)
leucine-rich repeat 409..432 CDD:275380 8/23 (35%)
leucine-rich repeat 433..456 CDD:275380 4/49 (8%)
leucine-rich repeat 458..481 CDD:275380 3/22 (14%)
leucine-rich repeat 482..505 CDD:275380 5/22 (23%)
leucine-rich repeat 506..529 CDD:275380 7/52 (13%)
leucine-rich repeat 530..551 CDD:275380 5/20 (25%)
leucine-rich repeat 554..577 CDD:275380 8/49 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 138 1.000 Inparanoid score I1805
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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