DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT3G08680

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_187480.1	Gene:	AT3G08680 / 820015	AraportID:	AT3G08680	Length:	640	Species:	Arabidopsis thaliana

Alignment Length:	687	Identity:	140/687 - (20%)
Similarity:	238/687 - (34%)	Gaps:	223/687 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1510 YGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEV- 1573
            |||:.     |..|:|.:..:......|..:    |....|.||...|..:||  :|.|.|..:
plant    80 YGPLP-----EKTFEKLDALRIISLRSNHLQ----GNIPSVILSLPFIRSLYF--HENNFSGTIP 133

  Fly  1574 ----------DDNERQLLAEIRPHMSQVAKLLALTVDHIDLL-------------------LEDW 1609
                      |.:...|...|...:..:.:|..|::.:..|.                   |...
plant   134 PVLSHRLVNLDLSANSLSGNIPTSLQNLTQLTDLSLQNNSLSGPIPNLPPRLKYLNLSFNNLNGS 198

  Fly  1610 YPSLGTRFVHTS-EGRFLI--TRLVLCPRCLWKLQLQQNNEPSDREVPPV---GCNRPSRSSRR- 1667
            .||....|..:| :|..|:  ..|..||        :....||.....|.   |.....|.:.:
plant   199 VPSSVKSFPASSFQGNSLLCGAPLTPCP--------ENTTAPSPSPTTPTEGPGTTNIGRGTAKK 255

  Fly  1668 --GAGAYFLHGVGDPGEDGALNVFSAYLNAT---ARRERRSEDSLGAGSDADSGVGPDSAGSSRN 1727
              ..||.....||     |::.:|......|   |::....:||        :.|.....|.|.|
plant   256 VLSTGAIVGIAVG-----GSVLLFIILAIITLCCAKKRDGGQDS--------TAVPKAKPGRSDN 307

  Fly  1728 TSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIP 1792
            .:.:...|              ::|.     .::|:   |..|.|               .:...
plant   308 KAEEFGSG--------------VQEA-----EKNKL---VFFEGS---------------SYNFD 335

  Fly  1793 SECIIKGS--LLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKW 1855
            .|.:::.|  :||:|::|..:||..: .|.    .|.:|.|:.|..|.|..|..:    .|||:
plant   336 LEDLLRASAEVLGKGSYGTTYKAILE-EGT----TVVVKRLKEVAAGKREFEQQM----EAVGR- 390

  Fly  1856 DRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI-KPLALVLELAPLGGLDALLRHYRRSG 1919
                                   ...|.|:.||..... |...|::.....||..::|.|....|
plant   391 -----------------------ISPHVNVAPLRAYYFSKDEKLLVYDYYQGGNFSMLLHGNNEG 432

  Fly  1920 --AHMGPHTFQTLVLQAARAIEYLHR---RRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIA 1979
              |.:...|...:.|:|||.|.::|.   .::::.::||.|||:       |::     :|:.::
plant   433 GRAALDWETRLRICLEAARGISHIHSASGAKLLHGNIKSPNVLL-------TQE-----LHVCVS 485

  Fly  1980 DYGI----SRQT-APSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFE 2039
            |:||    |..| .||.:.      |:.|||.|.   ..::|:|.|.:|||:.:.|.::.:...:
plant   486 DFGIAPLMSHHTLIPSRSL------GYRAPEAIE---TRKHTQKSDVYSFGVLLLEMLTGKAAGK 541

  Fly  2040 --GHESIKECILEGSRPALTQ---RE------------------TQFPTCCLDLMVLCWHEQPRR 2081
              |||.:.:.      |...|   ||                  .:.....|.:.:.|..:.|..
plant   542 TTGHEEVVDL------PKWVQSVVREEWTGEVFDVELIKQQHNVEEEMVQMLQIAMACVSKHPDS 600

  Fly  2082 RPTASQIVSIL----------------SAPECIHLLD 2102
            ||:..::|:::                |:||.|...|
plant   601 RPSMEEVVNMMEEIRPSGSGPGSGNRASSPEMIRSSD 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	76/331 (23%)
		STKc_LRRK	1801..2095	CDD:270902	76/343 (22%)
AT3G08680	NP_187480.1	LRRNT_2	25..63	CDD:369783
		PLN00113	<72..630	CDD:215061	136/678 (20%)
		leucine-rich repeat	94..117	CDD:275380	5/26 (19%)
		leucine-rich repeat	118..139	CDD:275380	6/22 (27%)
		leucine-rich repeat	140..163	CDD:275380	3/22 (14%)
		leucine-rich repeat	164..184	CDD:275380	3/19 (16%)
		PKc_like	347..614	CDD:389743	75/326 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050