DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and AT2G41820

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_181713.1	Gene:	AT2G41820 / 818781	AraportID:	AT2G41820	Length:	890	Species:	Arabidopsis thaliana

Alignment Length:	1015	Identity:	212/1015 - (20%)
Similarity:	360/1015 - (35%)	Gaps:	342/1015 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLD-AGA 169
            :...||..|.:| ||.|:..:...||     :...:.:|.:...::..:.|..:....:|| :|.
plant    15 LSKSELCEAQLS-DEATLVAINRELG-----VPGWSSNGTDYCTWVGLKCGVNNSFVEMLDLSGL 73

  Fly   170 DGRSHAVTKYSPLYAAVH---SGH---------------LGIARLMLDHFPELIQQPTVE--RWL 214
            ..|.: ||..|.|.:..|   ||:               |....|.|:.|...|   .||  :..
plant    74 QLRGN-VTLISDLRSLKHLDLSGNNFNGRIPTSFGNLSELEFLDLSLNRFVGAI---PVEFGKLR 134

  Fly   215 PLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQ------------WEWRLP----FDANAHD 263
            .|.|..|:.::.:.|:      ||.|....|.||.|            |...|.    |.|..:|
plant   135 GLRAFNISNNLLVGEI------PDELKVLERLEEFQVSGNGLNGSIPHWVGNLSSLRVFTAYEND 193

  Fly   264 VTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGI-------QAI 321
            :.|:    |.:.||   ||..|....||..:..|               :|..||       ..:
plant   194 LVGE----IPNGLG---LVSELELLNLHSNQLEG---------------KIPKGIFEKGKLKVLV 236

  Fly   322 MSKLHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANP 386
            :::..::||                 .|..|.:..|       |:::|.|:.::|..:.:...|.
plant   237 LTQNRLTGE-----------------LPEAVGICSG-------LSSIRIGNNELVGVIPRTIGNI 277

  Fly   387 NIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEA 451
            :.:.....|.|:         ||...:||..|..:|.:|:|           .|.|.|.|...|
plant   278 SGLTYFEADKNN---------LSGEIVAEFSKCSNLTLLNL-----------AANGFAGTIPTE- 321

  Fly   452 ILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSV 516
             |.:|            ||.:.|                           |:..:|:...:..|
plant   322 -LGQL------------INLQEL---------------------------ILSGNSLFGEIPKS- 345

  Fly   517 VRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLT-SIPQELFHLVSLRYLNVAQNKI 580
                ::.||.|                    .::|.|:|.|. :||:||..:..|:||.:.||.|
plant   346 ----FLGSGNL--------------------NKLDLSNNRLNGTIPKELCSMPRLQYLLLDQNSI 386

  Fly   581 T-DLPAPIGQTYGCPVLDELFLQDNQLT-TLPAAIFHLPALSI-LDVSNNKLQ-QLPFDLWRAPK 641
            . |:|..||   .|..|.:|.|..|.|| |:|..|..:..|.| |::|.|.|. .||.:|.:..|
plant   387 RGDIPHEIG---NCVKLLQLQLGRNYLTGTIPPEIGRMRNLQIALNLSFNHLHGSLPPELGKLDK 448

  Fly   642 LRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQS------------FEEPPSNKPRNVTQQRLT 694
            |..|:|:.|||.. .:||:  ...::||.::|..:            |::.|::       ..|.
plant   449 LVSLDVSNNLLTG-SIPPL--LKGMMSLIEVNFSNNLLNGPVPVFVPFQKSPNS-------SFLG 503

  Fly   695 HRNLWSATLDIT-----DND-MKWQHEQD-------LGDGKTAGVGSSQLSSLNIANNLFTSIPA 746
            ::.|..|.|..:     |.| :::.|...       :|.|..                :|.|:..
plant   504 NKELCGAPLSSSCGYSEDLDHLRYNHRVSYRIVLAVIGSGVA----------------VFVSVTV 552

  Fly   747 ALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCV- 810
            .:                |..|.......|..|.:|:..|          :.:..|.::..:..
plant   553 VV----------------LLFMMREKQEKAAAKNVDVEEN----------VEDEQPAIIAGNVFL 591

  Fly   811 -QLPEGRD-DDYKTASSKGSSSSATSFRASV---------------LKSVCRHRRHLRLEALRTL 858
             .|.:|.| |....|:.|.|:..:|...:||               |||:.|...|.:.:.:|.|
plant   592 ENLKQGIDLDAVVKATMKESNKLSTGTFSSVYKAVMPSGMIVSVKKLKSMDRAISHHQNKMIREL 656

  Fly   859 -----ILADNLLTRI--------------QLSTDDATTLFNESE-----DADWSV-----VGVNR 894
                 :..|:|:..|              .|...:.|.|.:||.     ..||.:     ||...
plant   657 ERLSKLCHDHLVRPIGFVIYEDVALLLHQHLPNGNLTQLIHESTKKPEYQPDWPMRLSIAVGAAE 721

  Fly   895 SKVIFPNLSMLDM---TNNCLKE--IPASLHELSSLSVLNIS-GNVNITE-------LPPHLGLL 946
            .......::::.:   ::|.|.:  ..|.|.|:....:|:.| |..:|:.       :||.....
plant   722 GLAFLHQVAIIHLDVSSSNVLLDSGYKAVLGEIEISKLLDPSRGTASISSVAGSFGYIPPEYAYT 786

  Fly   947 SRL---WNLNTRGCLLQEPL--RSMIESKKHKTMDIVGYL 981
            .::   .|:.:.|.:|.|.|  |:.:|.:..:.:|:|.::
plant   787 MQVTAPGNVYSYGVVLLEILTSRAPVEEEFGEGVDLVKWV 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560	24/107 (22%)
		ANK	146..286	CDD:238125	41/176 (23%)
		ANK repeat	146..177	CDD:293786	5/31 (16%)
		Ank_4	179..232	CDD:290365	16/72 (22%)
		ANK repeat	179..209	CDD:293786	10/47 (21%)
		Ank_2	216..389	CDD:289560	39/195 (20%)
		ANK	361..477	CDD:238125	25/115 (22%)
		ANK repeat	361..390	CDD:293786	5/28 (18%)
		Ank_2	364..464	CDD:289560	22/99 (22%)
		ANK repeat	406..435	CDD:293786	8/28 (29%)
		ANK repeat	437..464	CDD:293786	7/26 (27%)
		LRR_8	<544..580	CDD:290566	13/36 (36%)
		leucine-rich repeat	547..569	CDD:275380	8/22 (36%)
		LRR_8	569..629	CDD:290566	25/62 (40%)
		leucine-rich repeat	570..595	CDD:275380	11/25 (44%)
		leucine-rich repeat	596..618	CDD:275380	9/22 (41%)
		leucine-rich repeat	619..641	CDD:275380	9/23 (39%)
		leucine-rich repeat	642..676	CDD:275380	11/33 (33%)
		leucine-rich repeat	677..730	CDD:275380	11/65 (17%)
		LRR_8	729..788	CDD:290566	8/58 (14%)
		leucine-rich repeat	731..754	CDD:275380	2/22 (9%)
		LRR_8	855..933	CDD:290566	21/112 (19%)
		leucine-rich repeat	855..901	CDD:275380	14/74 (19%)
		leucine-rich repeat	902..924	CDD:275380	5/26 (19%)
		leucine-rich repeat	925..949	CDD:275380	6/31 (19%)
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568
		STKc_LRRK	1801..2095	CDD:270902
AT2G41820	NP_181713.1	PLN00113	43..886	CDD:215061	203/981 (21%)
		leucine-rich repeat	65..87	CDD:275380	8/22 (36%)
		leucine-rich repeat	88..111	CDD:275380	3/22 (14%)
		leucine-rich repeat	112..135	CDD:275380	7/25 (28%)
		LRR_RI	129..384	CDD:238064	77/392 (20%)
		leucine-rich repeat	136..159	CDD:275380	7/28 (25%)
		leucine-rich repeat	160..183	CDD:275380	5/22 (23%)
		leucine-rich repeat	184..207	CDD:275380	9/29 (31%)
		leucine-rich repeat	208..231	CDD:275380	7/37 (19%)
		leucine-rich repeat	232..255	CDD:275380	4/39 (10%)
		leucine-rich repeat	256..279	CDD:275380	5/22 (23%)
		leucine-rich repeat	280..303	CDD:275380	7/31 (23%)
		leucine-rich repeat	304..327	CDD:275380	10/47 (21%)
		leucine-rich repeat	328..351	CDD:275380	5/54 (9%)
		leucine-rich repeat	352..375	CDD:275380	9/42 (21%)
		leucine-rich repeat	376..399	CDD:275380	11/25 (44%)
		leucine-rich repeat	400..423	CDD:275380	9/22 (41%)
		leucine-rich repeat	424..448	CDD:275380	9/23 (39%)
		leucine-rich repeat	449..470	CDD:275380	8/23 (35%)
		STKc_IRAK	614..885	CDD:270968	42/213 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050