DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and SOBIR1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_180747.1	Gene:	SOBIR1 / 817746	AraportID:	AT2G31880	Length:	641	Species:	Arabidopsis thaliana

Alignment Length:	795	Identity:	152/795 - (19%)
Similarity:	264/795 - (33%)	Gaps:	245/795 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1363 LLNKFEVALTW---DSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQE-------V 1417
            ||:.|..::.|   ||..|....::.::........|...::...| |.:.|.....       :
plant    24 LLSSFVSSVEWLDIDSSDLKALQVIETELGVNSQRSSASDVNPCGR-RGVFCERRHSATTGEYVL 87

  Fly  1418 NLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQ 1482
            .:..|:|..||...:.|...                 |..|.|....|::.|::.|:....::.:
plant    88 RVTRLVYRSRSLTGTISPVI-----------------GMLSELKELTLSNNQLVNAVPVDILSCK 135

  Fly  1483 DYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIW 1547
            .....|||.        |.:...:...:..:...:|.::...|        ..||...||
plant   136 QLEVLDLRK--------NRFSGQIPGNFSSLSRLRILDLSSNK--------LSGNLNFLK----- 179

  Fly  1548 SDVNLSSSSILEVYFPLYEVNISQEV---------DDNERQLLAEIRPHMSQVAKLLALTVDHID 1603
               ||.:...|.|...|:...|.:::         |.:..:.|....|.||.:.
plant   180 ---NLRNLENLSVANNLFSGKIPEQIVSFHNLRFFDFSGNRYLEGPAPVMSSIK----------- 230

  Fly  1604 LLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRP------- 1661
                          :.||..:   ||.:|..........:.||..:.:  .|.|..:|
plant   231 --------------LQTSPHQ---TRHILAETPTSSPTNKPNNSTTSK--APKGAPKPGKLKKKK 276

  Fly  1662 SRSSRRGAGAYFL-HGVGDPGEDGALN--VFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAG 1723
            .:|.::...|:.| ..||..|  |.::  |||.......:..|.||...|
plant   277 KKSKKKKVAAWILGFVVGAIG--GTISGFVFSVLFKLIIQAIRGSEKPPG--------------- 324

  Fly  1724 SSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDK 1788
                      |....|                                 :.:.|.|:.|.:
plant   325 ----------PSIFSP---------------------------------LIKKAEDLAFLE---- 342

  Fly  1789 HTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVG 1853
               ..|.:....::|||..|.||||..                    ||:..|..|:.  ||...
plant   343 ---NEEALASLEIIGRGGCGEVFKAEL--------------------PGSNGKIIAVK--KVIQP 382

  Fly  1854 KWDRDPLQHSCKAYCT-----ARQELAVLLTLKHPNIVPLVGICIKPLA--LVLELAPLGGLDAL 1911
            ..|.|.|......:..     .|.|:..:..::|.|::||:....:|..  ||.|....|.|..:
plant   383 PKDADELTDEDSKFLNKKMRQIRSEINTVGHIRHRNLLPLLAHVSRPECHYLVYEYMEKGSLQDI 447

  Fly  1912 LRHYRRSGAHMGPHTFQTLVLQAARAIEYL---HRRRIIYRDLKSENVLVWELPQPHTEDSPRNL 1973
            |...:.....:.......:.|..|..:|||   |..|||:||||..|||:        :|.
plant   448 LTDVQAGNQELMWPARHKIALGIAAGLEYLHMDHNPRIIHRDLKPANVLL--------DDD---- 500

  Fly  1974 VHIKIADYGISRQTAPSG-----AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENIS 2033
            :..:|:|:|::: ..|..     .....||.|::|||..:   ..::|:|.|.:|||:.:...:.
plant   501 MEARISDFGLAK-AMPDAVTHITTSHVAGTVGYIAPEFYQ---THKFTDKCDIYSFGVILGILVI 561

  Fly  2034 LRQP---FEGHESIKECILEGSRPALTQRETQFPTCCLD------------LMVL-----CWHEQ 2078
            .:.|   |..|.. :..:::..|..:|   ::.|:..:|            |:||     |..:.
plant   562 GKLPSDEFFQHTD-EMSLIKWMRNIIT---SENPSLAIDPKLMDQGFDEQMLLVLKIACYCTLDD 622

  Fly  2079 PRRRPTASQIVSILS 2093
            |::||.:..:.::||
plant   623 PKQRPNSKDVRTMLS 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713	21/117 (18%)
		STYKc	1796..2092	CDD:214568	77/330 (23%)
		STKc_LRRK	1801..2095	CDD:270902	79/328 (24%)
SOBIR1	NP_180747.1	PLN00113	99..>233	CDD:215061	28/199 (14%)
		leucine-rich repeat	113..136	CDD:275380	4/22 (18%)
		leucine-rich repeat	137..160	CDD:275380	4/30 (13%)
		leucine-rich repeat	161..183	CDD:275380	8/37 (22%)
		leucine-rich repeat	184..207	CDD:275380	4/22 (18%)
		PKc_like	353..639	CDD:419665	79/327 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1805
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050