DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and ER

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_180201.1 Gene:ER / 817173 AraportID:AT2G26330 Length:976 Species:Arabidopsis thaliana


Alignment Length:1089 Identity:220/1089 - (20%)
Similarity:362/1089 - (33%) Gaps:414/1089 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  1206 NIIYDTAMQLRSPGSKEPMLLQKIPASY-----IALEDIV-NVIACNLRAAGRDPVLDGE----- 1259
            |::||..   .||.|           .|     ::.|::. ||:|.||    .|..||||     
plant    42 NVLYDWT---TSPSS-----------DYCVWRGVSCENVTFNVVALNL----SDLNLDGEISPAI 88

  Fly  1260 -QYKRLVTEQMRLHNYK-----SFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDM 1318
             ..|.|::..:|.:...     ...|.:.||.                        ||       
plant    89 GDLKSLLSIDLRGNRLSGQIPDEIGDCSSLQN------------------------LD------- 122

  Fly  1319 LAHVVTVREINPFAPTGVMKLDDL-QMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPS 1382
                ::..|::...|..:.||..| |::.::.|:.|.     |.|.|::             ||:
plant   123 ----LSFNELSGDIPFSISKLKQLEQLILKNNQLIGP-----IPSTLSQ-------------IPN 165

  Fly  1383 LLPSQEAATPNSGSTVKLSQRS--------RGRSLGCSVSQEV-NLNNLIY-EQRSAPSSSSSSA 1437
            |.....|....||...:|...:        ||.:|..::|.:: .|..|.| :.|    ::|.:.
plant   166 LKILDLAQNKLSGEIPRLIYWNEVLQYLGLRGNNLVGNISPDLCQLTGLWYFDVR----NNSLTG 226

  Fly  1438 SVSQGLR-----RILLMTY--------FPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDL 1489
            |:.:.:.     ::|.::|        |..|| .::.|..|...|:...|..|....|..|..||
plant   227 SIPETIGNCTAFQVLDLSYNQLTGEIPFDIGF-LQVATLSLQGNQLSGKIPSVIGLMQALAVLDL 290

  Fly  1490 RTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGN-----RFKLKQDGIWSD 1549
            ..:|            |:....|||                     ||     :..|..:.:...
plant   291 SGNL------------LSGSIPPIL---------------------GNLTFTEKLYLHSNKLTGS 322

  Fly  1550 V-----NLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDW 1609
            :     |:|....||:               |:..|...|.|.:.::..|..|.|.:.|  ||..
plant   323 IPPELGNMSKLHYLEL---------------NDNHLTGHIPPELGKLTDLFDLNVANND--LEGP 370

  Fly  1610 YP-------SLGTRFVHTSEGRFLITRLVLCPRCLWKLQ------LQQNN--EPSDREVPPVGCN 1659
            .|       :|.:..||.::....|      ||...||:      |..||  .|...|:..:|..
plant   371 IPDHLSSCTNLNSLNVHGNKFSGTI------PRAFQKLESMTYLNLSSNNIKGPIPVELSRIGNL 429

  Fly  1660 RPSRSSRRGAGAYFLHGVGD------------------PGEDGALNVFSAYLNATARRERRSEDS 1706
            .....|...........:||                  ||:.|.|               ||...
plant   430 DTLDLSNNKINGIIPSSLGDLEHLLKMNLSRNHITGVVPGDFGNL---------------RSIME 479

  Fly  1707 LGAGSDADSGVGPDSAGSSR--------NTSVDGHPGY-------------------HLPDNSN- 1743
            :...::..||..|:.....:        |.::.|:.|.                   .:|.|:| 
plant   480 IDLSNNDISGPIPEELNQLQNIILLRLENNNLTGNVGSLANCLSLTVLNVSHNNLVGDIPKNNNF 544

  Fly  1744 -------------VCYAWMIEEC---------------ILSVYNQSKI--------SCPVH---- 1768
                         :|.:|:...|               ||.:.....:        :|..|    
plant   545 SRFSPDSFIGNPGLCGSWLNSPCHDSRRTVRVSISRAAILGIAIGGLVILLMVLIAACRPHNPPP 609

  Fly  1769 -----LEQSMAQLAPDV----------IFADIPDKHTIPSECIIKGSLLGRGAFGFVFKA---NC 1815
                 |::.:....|.:          ::.||...    :|.:.:..::|.||...|:|.   ||
plant   610 FLDGSLDKPVTYSTPKLVILHMNMALHVYEDIMRM----TENLSEKYIIGHGASSTVYKCVLKNC 670

  Fly  1816 KVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTL 1880
                    ||||:|.|                       :..:|  .|.|.:.|   ||.:|.::
plant   671 --------KPVAIKRL-----------------------YSHNP--QSMKQFET---ELEMLSSI 699

  Fly  1881 KHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGA-----HMGPHTFQTL--------VL 1932
            ||.|:|.|         ....|:.||.|  |...|..:|:     | ||...:||        ..
plant   700 KHRNLVSL---------QAYSLSHLGSL--LFYDYLENGSLWDLLH-GPTKKKTLDWDTRLKIAY 752

  Fly  1933 QAARAIEYLHR---RRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKG 1994
            .||:.:.|||.   .|||:||:||.|:|:       .:|     :..::.|:||::....|.:..
plant   753 GAAQGLAYLHHDCSPRIIHRDVKSSNILL-------DKD-----LEARLTDFGIAKSLCVSKSHT 805

  Fly  1995 ---FGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILE--GSRP 2054
               ..||.|::.||   |......|||.|.:|:|:.:.|.::.|:..:...::...|:.  |:..
plant   806 STYVMGTIGYIDPE---YARTSRLTEKSDVYSYGIVLLELLTRRKAVDDESNLHHLIMSKTGNNE 867

  Fly  2055 ALTQRETQFPTCCLDLMV---------LCWHEQPRRRPTASQIVSILSA 2094
            .:...:....:.|.||.|         ||...||..|||..|:..:|.:
plant   868 VMEMADPDITSTCKDLGVVKKVFQLALLCTKRQPNDRPTMHQVTRVLGS 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359 2/4 (50%)
COR 1230..1471 CDD:292713 56/281 (20%)
STYKc 1796..2092 CDD:214568 84/328 (26%)
STKc_LRRK 1801..2095 CDD:270902 85/327 (26%)
ERNP_180201.1 PLN00113 7..916 CDD:215061 220/1087 (20%)
leucine-rich repeat 73..93 CDD:275380 7/23 (30%)
leucine-rich repeat 94..117 CDD:275380 3/22 (14%)
leucine-rich repeat 118..141 CDD:275380 8/57 (14%)
leucine-rich repeat 142..165 CDD:275380 8/40 (20%)
leucine-rich repeat 166..213 CDD:275380 10/46 (22%)
leucine-rich repeat 214..237 CDD:275380 5/26 (19%)
leucine-rich repeat 239..260 CDD:275380 5/21 (24%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
leucine-rich repeat 285..308 CDD:275380 10/55 (18%)
leucine-rich repeat 309..332 CDD:275380 2/22 (9%)
leucine-rich repeat 333..356 CDD:275380 6/37 (16%)
leucine-rich repeat 357..380 CDD:275380 7/24 (29%)
leucine-rich repeat 381..404 CDD:275380 8/28 (29%)
leucine-rich repeat 405..428 CDD:275380 5/22 (23%)
leucine-rich repeat 429..452 CDD:275380 3/22 (14%)
leucine-rich repeat 453..474 CDD:275380 3/20 (15%)
leucine-rich repeat 477..498 CDD:275380 3/20 (15%)
leucine-rich repeat 501..523 CDD:275380 3/21 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 138 1.000 Inparanoid score I1805
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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