DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and tnni3k

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	728	Identity:	164/728 - (22%)
Similarity:	256/728 - (35%)	Gaps:	232/728 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1566 EVNISQEVDDNERQLLAEIRP-HMSQVAKLLALTVDHIDLLL-------------EDWYP-SLGT 1615
            :||.|.||.|         || |::.....|.:    :.||:             ||..| ....
Zfish   192 DVNASGEVGD---------RPLHLAAAKGFLGI----VKLLMDDGSKTDVNAQDNEDHVPLHFCA 243

  Fly  1616 RFVHTSEGRFLIT-RLVLCPRCL-----WKLQLQQNN---EPSDREVPPVGCNRPSRSSRRGAGA 1671
            ||.|....|||:. ...:.|.|:     ..|.|...|   |.....:...|....|:.:.....|
Zfish   244 RFGHQEVVRFLLQGSFDVQPHCVNIYGDTPLHLACYNGKFEAVKEIIQLSGTESLSKENIFSETA 308

  Fly  1672 Y--------------FLHG-----VGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGV 1717
            :              :|.|     :...|.||...:.||..:...|..:...|:   |.|.:. |
Zfish   309 FHSACTFGKNLEMVKYLLGQNAMSINHQGRDGHTGLHSACFHGHIRLVQFLLDN---GGDMNL-V 369

  Fly  1718 GPDSAGSSRNTSVD---------GHPG-------YHLPDNSNVCYAWMIEECILSVYNQ-----S 1761
            ..|.:.||......         ||..       |..|.:.:.|          :.|:|     |
Zfish   370 ACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDDSPC----------NEYSQPGGDGS 424

  Fly  1762 KISCPVHLE--QSMAQLAPDVIF--ADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARS 1822
            .:|.|..|.  :||.:...||:.  |.:|....:....:....::|.|:||.|:|..|:
Zfish   425 YVSVPSPLGKIKSMTKEKADVLLLRASLPSNFHLQLSELEFNEIIGSGSFGKVYKGKCR------ 483

  Fly  1823 FKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVP 1887
            .|.||:|..:|               .....|.|.|       .:|   :|:::|..|.||.::.
Zfish   484 NKIVAIKRYRP---------------NTYCSKSDTD-------MFC---REVSILCRLNHPCVIQ 523

  Fly  1888 LVGICI---KPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHR--RRII 1947
            .||.|:   ...|:|.:....|.|.:||...:|.   :...:...:.:..|:.:||||.  :.||
Zfish   524 FVGACLDDPSQFAIVTQYVSGGSLFSLLHEQKRI---IDLQSKLIIAIDVAKGMEYLHNLTQPII 585

  Fly  1948 YRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISR---QTAPSGAKGFGGTEGFMAPEIIRY 2009
            :|||.|.|:|::       ||.     |..:||:|.||   ...........|...:||||:  :
Zfish   586 HRDLNSHNILLY-------EDG-----HAVVADFGESRFLLSVDEDNMTKQPGNLRWMAPEV--F 636

  Fly  2010 NGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQF----------- 2063
            .....||.|.|.||:.:.::|.::...|| .|          .:||....:..:
Zfish   637 TQCTRYTVKADMFSYALCLWELLTGEIPF-AH----------LKPAAAAADMAYHHVRPPIGYSI 690

  Fly  2064 PTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDER 2128
            |.....|::..|:..|..||..|::|:.|.  ||:
Zfish   691 PKPISALLMRGWNVCPEERPEFSEVVAKLE--ECL------------------------------ 723

  Fly  2129 CGLELWLPSFGSRIDILDCSPSGSLLQCNSISC-----SP-QPQVAPPKTP---ENGANSRA--- 2181
            |.:||..|:        ..:.||||...:|..|     || :..||..::.   |...|:||
Zfish   724 CNVELMSPA--------SSNSSGSLSPSSSTDCLAARGSPGRSHVAALRSRFELEYALNARAYAF 780

  Fly  2182 -------RSAQRL 2187
                   ||:|.|
Zfish   781 WTQNSARRSSQGL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	77/314 (25%)
		STKc_LRRK	1801..2095	CDD:270902	78/312 (25%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125	11/40 (28%)
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560	1/2 (50%)
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125	27/110 (25%)
		ANK repeat	166..197	CDD:293786	2/4 (50%)
		Ank_2	171..261	CDD:289560	21/81 (26%)
		ANK repeat	199..232	CDD:293786	8/45 (18%)
		ANK	229..360	CDD:238125	26/130 (20%)
		ANK repeat	269..302	CDD:293786	6/32 (19%)
		Ank_2	274..369	CDD:289560	18/98 (18%)
		ANK repeat	304..337	CDD:293786	3/32 (9%)
		ANK	334..>401	CDD:238125	15/70 (21%)
		ANK repeat	339..369	CDD:293786	8/33 (24%)
		Ank_2	344..>411	CDD:289560	14/70 (20%)
		TyrKc	463..719	CDD:197581	77/314 (25%)
		PKc_TNNI3K	469..722	CDD:270966	78/313 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900