DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and LRRK1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_078928.3	Gene:	LRRK1 / 79705	HGNCID:	18608	Length:	2015	Species:	Homo sapiens

Alignment Length:	2345	Identity:	543/2345 - (23%)
Similarity:	894/2345 - (38%)	Gaps:	673/2345 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 GDSASSVST----PITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCG 357
            ||:....||    |  ..|.|.:.||:|...:    |:..|..||..:   .|.:        |.
Human    35 GDTGGKPSTRGGDP--AARSRRTEGIRAAYRR----GDRGGARDLLEE---ACDQ--------CA 82

  Fly   358 AARETALLAAVRG--GHLDVVQSLLQHGANPNIVAKPVEDHND-PKCCEEIYG--------LSNV 411
            :..|...|.::..  |.|::|:.||    :..:|..|.|..:| |......:|        |.::
Human    83 SQLEKGQLLSIPAAYGDLEMVRYLL----SKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESL 143

  Fly   412 P------------IAEACKQRSLAMLDLL-LKHGARDDNGTAIG-------------MAITCGDE 450
            |            :|.||::..|.::.|| |.||| |....|:.             .||..|:|
Human   144 PGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGA-DPESYAVRKNEFPVIVRLPLYAAIKSGNE 207

  Fly   451 AILSRLLARRVH---------PDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTI-IDW 505
            .|...||....:         ||....:.:|..   :|.:. |||:        :|....: :.|
Human   208 DIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF---IEASP-LPSS--------YPGKTALRVKW 260

  Fly   506 HSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQEL-FHLVS 569
                     |.:|:|| |....|::...|            ||.:|.|.|.|.::|..: :.|::
Human   261 ---------SHLRLPW-VDLDWLIDISCQ------------ITELDLSANCLATLPSVIPWGLIN 303

  Fly   570 LRYLNVAQNKITDLP-APIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLP 633
            ||.||::.|.:.:|| ........|..|.|:.:..|:|:.||....||..|..|..|.|.|::|
Human   304 LRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKL- 367

  Fly   634 FDLWRAP------KLRELNVAFNLLRDLPVPPMQTSSSL--LSLDKLNLQSFEEPPSNKPRNVTQ 690
            |:...|.      ||:||:::.|.|.:||...:.:..||  |::.:.||:.|.:|
Human   368 FEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDP---------- 422

  Fly   691 QRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNL 755
                    |:..|......   ::..:....|.|....:.|..::.:.|....:|..|..|.. |
Human   423 --------WACPLKCCKAS---RNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDA-L 475

  Fly   756 TRLNMSYNSLRSMGHVTSYPA-TLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDD 819
            ..|.:..|.|.::.....:.. .||.||||.|::                          |:::|
Human   476 MFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQL--------------------------GKNED 514

  Fly   820 -YKTA-----SSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTL 878
             .||.     :::|...|.|. .||||:
Human   515 GLKTKRIAFFTTRGRQRSGTE-AASVLE------------------------------------- 541

  Fly   879 FNESEDADWSVVGVNRSKVIFP-----NLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITE 938
                                ||     :|.:|.:.:|.|..:|.|:..|.|||.|.:..|..:.|
Human   542 --------------------FPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRE 586

  Fly   939 LPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAG 1003
            |||.||.|..||.|:|....:.. :.:.|:.:..|.|  :.||::....|:....||:::||...
Human   587 LPPELGQLGNLWQLDTEDLTISN-VPAEIQKEGPKAM--LSYLRAQLRKAEKCKLMKMIIVGPPR 648

  Fly  1004 IGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGT 1068
            .||||||::|:.|.                  |.::.|..:|.|:.:
Human   649 QGKSTLLEILQTGR------------------APQVVHGEATIRTTK------------------ 677

  Fly  1069 WICEKRKRAPGSHG---PVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQW 1130
            |   :.:|..||..   .|.|..||.||.......:|.|.:.::||:|:|.::.|.:.:|.|..|
Human   678 W---ELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFW 739

  Fly  1131 LGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVI--DSIEI 1193
            |.||:|:|||:.|::||||.|.:......::...|:..:.....:...:...|.|.:.  ...||
Human   740 LLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEI 804

  Fly  1194 SCRTLHNIHLLANIIYDTAMQLRSPGSK---EPMLLQKIPASYIALEDIVNVIACNLRAAGRDPV 1255
            ||::|.....|..:|:.....::..||.   :.:..:.||.||::|::.  |:|...|.:..|.|
Human   805 SCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEA--VLAEQQRRSRDDDV 867

  Fly  1256 --LDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDAT--LRDYYFLDPQWLC 1316
              |...|.::|| ||...::.|.:.|   ||.|.::..|.|.|||:.|.:  ||:.|||||.||.
Human   868 QYLTDRQLEQLV-EQTPDNDIKDYED---LQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLS 928

  Fly  1317 DMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIP 1381
            :.|..:..::.....|..||::.:||:||.............|. ..|.|||:||...:.:.|:|
Human   929 ECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYF-QFLAKFEIALPVANDSYLLP 992

  Fly  1382 SLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRI 1446
            .||||:.....:.                                ...|::::        ::|:
Human   993 HLLPSKPGLDTHG--------------------------------MRHPTANT--------IQRV 1017

  Fly  1447 LLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYG 1511
            ..|::.|.|||.|.|.|:|           :.:|..|...|:.:.:.:...:
Human  1018 FKMSFVPVGFWQRFIARML-----------ISLAEMDLQLFENKKNTKSRNR------------- 1058

  Fly  1512 PILIFKIWEVPFQKTERTQ--PFRTDGNRFKLKQDGIW------------SDVN--LSSSSILEV 1560
                 |:....|...:|.:  .||...|:....|:|:.            ||||  ...|..:::
Human  1059 -----KVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKI 1118

  Fly  1561 YFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRF 1625
                    :.|          :|:|...:     :|...||::.|::.|:|:|...   .|:|..
Human  1119 --------VCQ----------SEVRDFSA-----MAFITDHVNSLIDQWFPALTAT---ESDGTP 1157

  Fly  1626 LITRLVLCPRC--LWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNV 1688
            |:.:.|.||.|  .|    .|:.:||:
Human  1158 LMEQYVPCPVCETAW----AQHTDPSE-------------------------------------- 1180

  Fly  1689 FSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEEC 1753
                         :|||                                      |.| :.:|:|
Human  1181 -------------KSED--------------------------------------VQY-FDMEDC 1193

  Fly  1754 ILSVYNQSKISCPVH--LEQSMAQLAPDVIFADIPDKHTIPSECI----IKGSLLGRGAFGFVFK 1812
            :|:...:..||||.|  |...:.:|.|::...|.|.:..:.:..:    .:||:||:|..|.|.
Human  1194 VLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVI- 1257

  Fly  1813 ANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQH-----SCKAYCTARQ 1872
                .|.....:|||:|...            :..||..........|:|     :.|.:...||
Human  1258 ----YRARYQGQPVAVKRFH------------IKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 1306

  Fly  1873 ELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAH--MGPHTFQTLVLQAA 1935
            |.::|..|:||.||.|:||.|.||...||||||..|:.:|....|..:.  :|....|.:..|.|
Human  1307 EASMLHALQHPCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIA 1371

  Fly  1936 RAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEG 2000
            ..:.|||::.||:.||||:|:|||.|       ..:..::||::|||||||:...||.|..||.|
Human  1372 SGLAYLHKKNIIFCDLKSDNILVWSL-------DVKEHINIKLSDYGISRQSFHEGALGVEGTPG 1429

  Fly  2001 FMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHE--SIKECILEGSRPALTQ-RETQ 2062
            :.||||   .....|.||||.||:||.:||.:|.::|..||.  .|.:.:.:|.||.|.| .|.|
Human  1430 YQAPEI---RPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQ 1491

  Fly  2063 FPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDE 2127
            |.. ...||:.||..:|.:||.|..:||.:..|.....:        .::.||. |:.......:
Human  1492 FRR-LQALMMECWDTKPEKRPLALSVVSQMKDPTFATFM--------YELCCGK-QTAFFSSQGQ 1546

  Fly  2128 RCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNM 2192
            ...:..|.....||...:..:..| |::...:.|                          |.|.:
Human  1547 EYTVVFWDGKEESRNYTVVNTEKG-LMEVQRMCC--------------------------PGMKV 1584

  Fly  2193 LCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFS--YMLD-PNIKSAVISLVYMEKIA-RVAVGTHN 2253
            .|...|..::|.......::.|:......|.:  ..|| |.:.:..:::..::|.: .|..|..:
Human  1585 SCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLAD 1649

  Fly  2254 G--RVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNE 2316
            |  .||.|.......:|::         :||.....:..|:..:.          .:.|.:|
Human  1650 GLVAVFPVVRGTPKDSCSY---------LCSHTANRSKFSIADED----------ARQNPYP--- 1692

  Fly  2317 NGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPC 2381
                                ||...:.::.|.|:....||.:|             :||:.|..|
Human  1693 --------------------VKAMEVVNSGSEVWYSNGPGLLV-------------IDCASLEIC 1724

  Fly  2382 SESLQSIAIDEHVNLIKC---------------QISALAAHNSELY-IGTTWGCLIVAELHTLRP 2430
             ..|:.......|..:.|               :.::|..::|..| :...:.|.:.:.|..:.|
Human  1725 -RRLEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFP 1788

  Fly  2431 ISVFRPYENEIKSIITLSKDNVP---LIATIGRRY-RSLISRYVDSAESST----KSSAVSTPTH 2487
            :   ||.:.|..:....:...||   .||.:...| ..|.::.:...||.|    .||..|:|..
Human  1789 V---RPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPR 1850

  Fly  2488 GAAKS 2492
            .||:|
Human  1851 QAARS 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560	23/97 (24%)
		ANK	361..477	CDD:238125	37/161 (23%)
		ANK repeat	361..390	CDD:293786	7/30 (23%)
		Ank_2	364..464	CDD:289560	33/145 (23%)
		ANK repeat	406..435	CDD:293786	13/49 (27%)
		ANK repeat	437..464	CDD:293786	8/48 (17%)
		LRR_8	<544..580	CDD:290566	13/36 (36%)
		leucine-rich repeat	547..569	CDD:275380	8/22 (36%)
		LRR_8	569..629	CDD:290566	20/60 (33%)
		leucine-rich repeat	570..595	CDD:275380	8/25 (32%)
		leucine-rich repeat	596..618	CDD:275380	8/21 (38%)
		leucine-rich repeat	619..641	CDD:275380	8/27 (30%)
		leucine-rich repeat	642..676	CDD:275380	12/35 (34%)
		leucine-rich repeat	677..730	CDD:275380	6/52 (12%)
		LRR_8	729..788	CDD:290566	16/59 (27%)
		leucine-rich repeat	731..754	CDD:275380	5/22 (23%)
		LRR_8	855..933	CDD:290566	13/82 (16%)
		leucine-rich repeat	855..901	CDD:275380	2/50 (4%)
		leucine-rich repeat	902..924	CDD:275380	7/21 (33%)
		leucine-rich repeat	925..949	CDD:275380	11/23 (48%)
		P-loop_NTPase	993..1211	CDD:304359	59/222 (27%)
		COR	1230..1471	CDD:292713	67/244 (27%)
		STYKc	1796..2092	CDD:214568	112/309 (36%)
		STKc_LRRK	1801..2095	CDD:270902	110/303 (36%)
LRRK1	NP_078928.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..56		7/22 (32%)
		ANK 1	86..116		8/33 (24%)
		ANK	95..214	CDD:238125	30/123 (24%)
		ANK 2	119..148		5/28 (18%)
		Ank_2	126..221	CDD:289560	22/95 (23%)
		ANK 3	152..182		11/30 (37%)
		ANK repeat	156..186	CDD:293786	12/30 (40%)
		ANK repeat	188..218	CDD:293786	7/29 (24%)
		ANK 4	193..222		7/28 (25%)
		LRR_RI	<214..488	CDD:238064	77/330 (23%)
		LRR 1	279..300		8/32 (25%)
		leucine-rich repeat	281..303	CDD:275380	7/21 (33%)
		LRR	302..614	CDD:227223	95/419 (23%)
		LRR 2	303..324		7/20 (35%)
		leucine-rich repeat	304..330	CDD:275380	8/25 (32%)
		LRR 3	330..351		6/20 (30%)
		leucine-rich repeat	331..353	CDD:275380	8/21 (38%)
		LRR 4	353..374		7/21 (33%)
		leucine-rich repeat	354..381	CDD:275380	8/27 (30%)
		LRR_RI	379..641	CDD:238064	78/370 (21%)
		LRR 5	381..402		8/20 (40%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		LRR 6	405..426		8/38 (21%)
		leucine-rich repeat	406..451	CDD:275380	10/65 (15%)
		LRR 7	427..447		3/22 (14%)
		LRR 8	451..472		4/20 (20%)
		leucine-rich repeat	452..474	CDD:275380	5/21 (24%)
		LRR 9	474..495		4/21 (19%)
		leucine-rich repeat	475..498	CDD:275380	4/22 (18%)
		LRR 10	498..519		10/46 (22%)
		leucine-rich repeat	499..549	CDD:275380	20/133 (15%)
		LRR 11	549..570		6/20 (30%)
		leucine-rich repeat	550..572	CDD:275380	7/21 (33%)
		LRR 12	572..594		11/21 (52%)
		LRR 13	596..617		5/21 (24%)
		Gem1	635..>781	CDD:224025	50/184 (27%)
		P-loop_NTPase	639..821	CDD:304359	59/220 (27%)
		COR	844..1036	CDD:292713	66/238 (28%)
		S_TKc	1245..1511	CDD:214567	107/293 (37%)
		STKc_LRRK1	1248..1523	CDD:270969	110/302 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1788..1810		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1841..1899		7/15 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4311
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10820at33208
OrthoFinder	1	1.000	-	-		FOG0007008
OrthoInspector	1	1.000	-	-		otm42176
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830