DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and mos

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_991143.1	Gene:	mos / 795517	ZFINID:	ZDB-GENE-040428-3	Length:	329	Species:	Danio rerio

Alignment Length:	309	Identity:	79/309 - (25%)
Similarity:	126/309 - (40%)	Gaps:	65/309 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866
            :|.|.||.||      ||....:.||:|.::.|.....:::|.......|       .|.|.
Zfish    66 IGSGGFGTVF------RGTYFGETVAVKKVKCVKNKLASRQSFWAELNAA-------HLHHQ--- 114

  Fly  1867 YCTARQELAVLLTLKHPNIVPLVGICIKPLA-------LVLELAPLGGLDALLRHYRRSGAHMGP 1924
             ...|...|...|..|.|....:|..:...|       |:..|..|..::..:::
Zfish   115 -NIVRVLAATTCTPAHLNTKDNIGTIVMEFAGNINLQKLIYGLTDLLPVEKCIKY---------- 168

  Fly  1925 HTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAP 1989
                  .:..|||:::||...:::.|||..|||:.|...            .||||:|.|.:.:.
Zfish   169 ------SIDIARALQHLHAHGVVHLDLKPANVLLSEQGV------------CKIADFGCSFKISS 215

  Fly  1990 SG-----AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEG-HESIKECI 2048
            :.     ....|||....|||:::   .||.:.:||.:|||:.:::.::...|:|| .:.|...:
Zfish   216 TSDTVTHMNEIGGTFTHRAPELLK---GEEVSPRVDVYSFGITLWQLLTREPPYEGDRQYILYAV 277

  Fly  2049 LEGSRPALTQRE--TQF--PTCCLDLMVLCWHEQPRRRPTASQIVSILS 2093
            :..:...||.|.  |||  ...|..|:..||...|..||||.:.|..||
Zfish   278 VGYNLRPLTSRNVFTQFFIGQNCQKLISRCWDGDPSIRPTADKFVDELS 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	77/306 (25%)
		STKc_LRRK	1801..2095	CDD:270902	79/309 (26%)
mos	NP_991143.1	STKc_Mos	56..329	CDD:270881	79/309 (26%)
mos	NP_991143.1	S_TKc	63..320	CDD:214567	76/301 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900