Protein Alignment Lrrk and Mlkl

DIOPT Version :9

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_001297542.1
• Gene: Mlkl / 74568
• MGIID: 1921818
• Length: 472
• Species: Mus musculus
• Alignment Length: 378
• Identity: 87/378 - (23%)
• Similarity: 153/378 - (40%)
• Gaps: 79/378 - (20%)

  Fly  1741 NSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRG 1805
            |.|:....|..:..:...|::...|.:...|.:.|   |:...:||.:|..|....:|.|
Mouse   145 NENMKVILMQLQISVEEINKTLKQCSLKPTQEIPQ---DLQIKEIPKEHLGPPWTKLKTS----- 201

  Fly  1806 AFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTA 1870
                  |.:...||.....||.:|:..    ..:|:...::.|                    |.
Mouse   202 ------KMSTIYRGEYHRSPVTIKVFN----NPQAESVGIVRF--------------------TF 236

  Fly  1871 RQELAVLLTLKHPNIVPLVGICI----KP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQT 1929
            ..|:..:.....|||:.:.||||    ||  .::|:|...||.|..||.  |.....|...:.
Mouse   237 NDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLD--REKDLTMSVRSL-- 297

  Fly  1930 LVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISR------QTA 1988
            |||:|||.:..||....::|::.|.:.||            .....:|:|.:.:|:      :||
Mouse   298 LVLRAARGLYRLHHSETLHRNISSSSFLV------------AGGYQVKLAGFELSKTQNSISRTA 350

  Fly  1989 PSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHES--IKECILEG 2051
            .|.......:..:::||.:: |....|..|.:.:|||:.::|..:.:.||||.:|  |:|.:.|.
Mouse   351 KSTKAERSSSTIYVSPERLK-NPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAED 414

  Fly  2052 SRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTA--------SQIVSILSAPE 2096
            .:.....::.  |....:::..|...:|.:||:.        .:|:..|||.|
Mouse   415 KKQEPVGQDC--PELLREIINECRAHEPSQRPSVDGRSLSGRERILERLSAVE 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	71/317 (22%)
		STKc_LRRK	1801..2095	CDD:270902	71/315 (23%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250|UniProtKB:Q8NB16	1..143
		PHA02988	198..446	CDD:165291	70/301 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900