DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and Ripk4

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_076152.2 Gene:Ripk4 / 72388 MGIID:1919638 Length:786 Species:Mus musculus


Alignment Length:398 Identity:93/398 - (23%)
Similarity:147/398 - (36%) Gaps:115/398 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866
            :|.|.||.|:    |||.......:|:|....:....|.:...|...|                 
Mouse    28 VGSGGFGQVY----KVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAK----------------- 71

  Fly  1867 YCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLR--------HYRRSGAHMG 1923
                :.|:|     |...|:|:.|||.:|:.||:|....|.|:.||.        .:|       
Mouse    72 ----KMEMA-----KFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFR------- 120

  Fly  1924 PHTFQTLVLQAARAIEYLH--RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQ 1986
                  :|.:.|..:.:||  ...:::.|||..|:|:    ..|        .|:||:|:|:::.
Mouse   121 ------IVHETAVGMNFLHCMSPPLLHLDLKPANILL----DAH--------YHVKISDFGLAKC 167

  Fly  1987 TAPS-----GAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKE 2046
            ...|     ...|..||..::.||.|| .....:..|.|.:||.:.|:..::.::||...::|..
Mouse   168 NGMSHSHDLSMDGLFGTIAYLPPERIR-EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILH 231

  Fly  2047 C---ILEGSRPALTQRETQFPTCC---LDLMVLCWHEQPRRRPTASQIVSIL------------- 2092
            .   :::|.||.|.......|..|   :.||..|||..|:.|||..:|.|..             
Mouse   232 IMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKD 296

  Fly  2093 ----------------SAPECIHLLDVVAMPHS---------EKIVCGVFQSLVGMGDDERCGLE 2132
                            :.||...|....|.|..         .::..|:.|:|.|..:..|...|
Mouse   297 LAHEPGEKSSLESKSEARPESSRLKRASAPPFDNDCSLSELLSQLDSGISQTLEGPEELSRSSSE 361

  Fly  2133 LWLPSFGS 2140
            ..|||..|
Mouse   362 CKLPSSSS 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568 78/310 (25%)
STKc_LRRK 1801..2095 CDD:270902 78/342 (23%)
Ripk4NP_076152.2 STKc_RIP4_like 25..290 CDD:270927 78/317 (25%)
TyrKc 26..279 CDD:197581 76/306 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..328 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..378 9/23 (39%)
ANK 1 439..468
ANK repeat 442..470 CDD:293786
Ank_2 444..536 CDD:289560
ANK 471..591 CDD:238125
ANK 2 472..501
ANK repeat 473..503 CDD:293786
ANK repeat 505..536 CDD:293786
ANK 3 505..534
Ank_2 510..602 CDD:289560
ANK repeat 538..569 CDD:293786
ANK 4 538..567
ANK repeat 571..602 CDD:293786
ANK 5 571..601
ANK 600..725 CDD:238125
ANK repeat 605..636 CDD:293786
ANK 6 605..634
Ank_2 610..701 CDD:289560
ANK repeat 638..669 CDD:293786
ANK 7 638..667
ANK repeat 671..701 CDD:293786
ANK 8 671..700
Ank_2 676..766 CDD:289560
ANK 9 704..734
ANK 731..>766 CDD:238125
ANK repeat 736..766 CDD:293786
ANK 10 736..765
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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