DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and Lrrk2

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_080006.3	Gene:	Lrrk2 / 66725	MGIID:	1913975	Length:	2527	Species:	Mus musculus

Alignment Length:	2810	Identity:	609/2810 - (21%)
Similarity:	980/2810 - (34%)	Gaps:	1036/2810 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LVQPLDHPTPTKRQIKTNATHSPNATFLNKCNSCRASWAPTC---AVRHK--------TAW-IND 86
            |.|.|:..:.|:.|.:..             :|.:..|...|   .|||:        ..| :|:
Mouse   327 LNQDLEERSETQEQSEEE-------------DSEKLFWLEPCYKALVRHRKDKHVQEAACWALNN 378

  Fly    87 --------HKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPS 143
                    |:.:..:..||.|..||.      |...:.|..:...:....||.|       :...
Mouse   379 LLMYQNSLHEKIGDEDGQFPAHREVM------LSMLMHSSSKDVFQAAAHALST-------LLEQ 430

  Fly   144 GANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQ- 207
            ..|....|..:..|.::.:.:       :.||   ::|..|  .||...::.|.....|.|...
Mouse   431 NVNFRKILLAKGVYLNVLELM-------QKHA---HAPEVA--ESGCKMLSHLFEGSNPSLDTMA 483

  Fly   208 ---PTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLP-------FDANAH 262
               |.:...:..|...::..::.|..::.:..|..|.::..|.:.:     |       |..:.|
Mouse   484 AVVPKILTVMKAHGTSLSVQLEALRAILHFVVPGLLEESREDSQCR-----PNVLRKQCFRTDIH 543

  Fly   263 -------------------------------DVTGQTSLY--IASILGNKQ-------------- 280
                                           |.|...||.  :.|:|...|
Mouse   544 KLVLVALNRFIGNPGIQKCGLKVISSLAHLPDATETLSLQGAVDSVLHTLQMYPDDQEIQCLGLH 608

  Fly   281 LVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRI-------SFGIQAIMSKLHISGE-------- 330
            |:|.|:..:..|..| |...:.:   :..|.:|.       :.|:|..:|.|.:|..
Mouse   609 LMGCLMTKKNFCIGT-GHLLAKI---LASTLQRFKDVAEVQTTGLQTTLSILELSVSFSKLLVHY 669

  Fly   331 -------SEGPDDLASQESTE----CQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGA 384
                   .:....:..|:..:    |.:|...| .:....:.|.|..|....:..:|:.||..||
Mouse   670 SFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKV-AVDDELKNTMLERACDQNNSIMVECLLLLGA 733

  Fly   385 NPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEAC-KQRSLAMLDLLLKHGARD-DNGTAIGMAITC 447
            :.|                ::.|.::: |.:.| |:.|..:::|||..|.|: |...|:.::|..
Mouse   734 DAN----------------QVKGATSL-IYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQK 781

  Fly   448 GDEAILSRLLAR--------------------------RVHPD---------------------- 464
            ||..::|.||.:                          .:.||
Mouse   782 GDSQVISLLLRKLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLARKVLRY 846

  Fly   465 -------------SDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGS------ 510
                         ||.|.::..|....|. .|:|.:   |..::|..:.   |..|.||
Mouse   847 QMRNTLQEGVASGSDGKFSEDALAKFGEW-TFIPDS---SMDSVFGQSD---DLDSEGSESSFLV 904

  Fly   511 ---SVQLSVVRV----------------------------------PWMVSGVLLLNPKLQSHPR 538
               |..:||..|                                  ..:.|...|.:.:|.||.|
Mouse   905 KRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLRSSRLPSHMR 969

  Fly   539 LNEVALTA------ITRIDFSHNVLTSI---PQEL---FHLVSLRYLNVAQNKITDLPAPIGQTY 591
            .::.:.:.      ||.:|.|.|.|..|   .|:.   .||..|..|.:.||.:|..|..:.:|.
Mouse   970 QSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETL 1034

  Fly   592 GCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKL-QQLPFD-LWRAPKLRELNVAFNLLRD 654
            .|  |..|.|..|:.|:.|:.:..:|.::.||.|.|.: ..:..| ..:.|.|::||:::|.|
Mouse  1035 KC--LIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAMKCPSLKQLNLSYNQL-- 1095

  Fly   655 LPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQ--QRLTHRNLWSATLDITDNDMKWQHEQD 717
                                       |:.|.|:.|  ::|                     ||.
Mouse  1096 ---------------------------SSIPENLAQVVEKL---------------------EQL 1112

  Fly   718 LGDG-KTAGVGS----SQLSSLNIANNLFTSIP--------------------AALPCLAVNLTR 757
            |.:| |.:|:.|    .:|..||::.|...|:|                    ||:|.|..::|.
Mouse  1113 LLEGNKISGICSPLSLKELKILNLSKNHIPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITS 1177

  Fly   758 LNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKT 822
            |.:|.||...:.........|:.||:|||.|.|.|.
Mouse  1178 LKLSQNSFTCIPEAIFSLPHLRSLDMSHNNIECLPG----------------------------- 1213

  Fly   823 ASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADW 887
                                    ..|.:...||.||.:.|     |:||.|    |:|:... |
Mouse  1214 ------------------------PAHWKSLNLRELIFSKN-----QISTLD----FSENPHV-W 1244

  Fly   888 SVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNL 952
            |            .:..|.:::|.|||||..:..|.:|:.|::|.|:.:...|..:|.||::|:|
Mouse  1245 S------------RVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL 1297

  Fly   953 NTRGCLLQEPLRSMIESKKH---KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLL---- 1010
            ...|..|....       ||   |..||:.:|:...:.|.||.|||||:||..|.||:|||
Mouse  1298 PLDGLHLNFDF-------KHVGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLM 1355

  Fly  1011 -----DLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW- 1069
                 :|..|||                                           |||:|:..|
Mouse  1356 KMKKPELGMQGA-------------------------------------------TVGIDVRDWS 1377

  Fly  1070 --ICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLG 1132
              |..||::      .:|...|||.|::|:|:||.:|:::|:|||.::.:|.|...:..:..||.
Mouse  1378 IQIRGKRRK------DLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLF 1436

  Fly  1133 NIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRT 1197
            ||:|||.:||||:||||.|...|.   |:...:.::.:|..      .|.|.|           |
Mouse  1437 NIKARASSSPVILVGTHLDVSDEK---QRKACISKITKELL------NKRGFP-----------T 1481

  Fly  1198 LHNIHLL-ANIIYDTAMQLRSPGSKE---------PMLLQKIPASYIALEDIVNVIACNLRAAGR 1252
            :.:.|.: |....|...:||.....|         |::.|.||..|:.||   .:|....:|...
Mouse  1482 IRDYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELE---KIILSERKAVPT 1543

  Fly  1253 D-PVLDGEQYKRLVTE-QMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLR--DYYFLDPQ 1313
            : ||::.:...:||.| |::|       |..||..|..:.:|:|||||:.|..|:  |.||::|:
Mouse  1544 EFPVINRKHLLQLVNEHQLQL-------DENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPK 1601

  Fly  1314 WLCDMLAHVVTVREINPFA-PTGVMKLDDLQ-MLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSR 1376
            |||.::|.::||:...... |.|::...|:: .|.:..:...|....|. .||.||::||.....
Mouse  1602 WLCKVMAQILTVKVDGCLKHPKGIISRRDVEKFLSKKKRFPKNYMMQYF-KLLEKFQIALPIGEE 1665

  Fly  1377 TLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQ 1441
            .||:||.|....       ..::|                             |...:|...:
Mouse  1666 YLLVPSSLSDHR-------PVIEL-----------------------------PHCENSEIII-- 1692

  Fly  1442 GLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGL 1506
               |:..|.|||.|||||||.|:|
Mouse  1693 ---RLYEMPYFPMGFWSRLINRLL----------------------------------------- 1713

  Fly  1507 ALYYGPILIFKIWEV-PFQKTERTQPFRTDGNRFKLKQDGI---WSDVNLSSSSILEVYFPLYEV 1567
                         |: ||..:.|.:..|.  ||...:| ||   ||.         |.|     .
Mouse  1714 -------------EISPFMLSGRERALRP--NRMYWRQ-GIYLNWSP---------EAY-----C 1748

  Fly  1568 NISQEVDDNERQLLAEIR-PHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLV 1631
            .:..||.||..:...:|. |...:...||...|||||.|:|:|:|.| .......||..|:.:
Mouse  1749 LVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGL-LEIDICGEGETLLKK-- 1810

  Fly  1632 LCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNAT 1696
                  |.|....:.|...:                    ..|..:....|:|
Mouse  1811 ------WALYSFNDGEEHQK--------------------ILLDELMKKAEEG------------ 1837

  Fly  1697 ARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQS 1761
                             |..:.||                                       |.
Mouse  1838 -----------------DLLINPD---------------------------------------QP 1846

  Fly  1762 KISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECI----IKGSLLGRGAFGFVFKANCKVRGARS 1822
            :::.|:      :|:|||:|.||:|....:.::.:    ....|||.|:||.|::|      |..
Mouse  1847 RLTIPI------SQIAPDLILADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRA------AYE 1899

  Fly  1823 FKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVP 1887
            .:.||:|:..        |.::|...                      ||||.||..|.||:::.
Mouse  1900 GEEVAVKIFN--------KHTSLRLL----------------------RQELVVLCHLHHPSLIS 1934

  Fly  1888 LVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLK 1952
            |:...|:|..||:|||..|.||.||:..:.|......|   .:.|..|..:.|||...|||||||
Mouse  1935 LLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQH---RIALHVADGLRYLHSAMIIYRDLK 1996

  Fly  1953 SENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTE 2017
            ..|||::.|       .|...:..|||||||::.....|.|...||.||.|||:.|  |...|.:
Mouse  1997 PHNVLLFTL-------YPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR--GNVIYNQ 2052

  Fly  2018 KVDCFSFGMFIYE--------NISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLD-LMVL 2073
            :.|.:|||:.:::        ...||.|.|    ..|..::|..|...:.....|...:: |:..
Mouse  2053 QADVYSFGLLLHDIWTTGSRIMEGLRFPNE----FDELAIQGKLPDPVKEYGCAPWPMVEKLITK 2113

  Fly  2074 CWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSL--------VGMGDDERCG 2130
            |..|.|:.|||::|:..||::.|.|.|:..:.:|.:..:.|.|..:|        :|.|:.|:..
Mouse  2114 CLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNLNSKSATLWLGCGNTEKGQ 2178

  Fly  2131 LELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCC 2195
            |.|:        |:                                 |:...|.:.:....:||.
Mouse  2179 LSLF--------DL---------------------------------NTERYSYEEVADSRILCL 2202

  Fly  2196 CLVGEAI----WM--GDVSGNLHAYST--STYAHLFSYMLDPNIKSAVISLVYMEKIAR------ 2246
            .||..|.    |:  |..||.|...:.  .|..|....|.|.      ::.::...:|:
Mouse  2203 ALVHLAAEKESWVVCGTQSGALLVINVEEETKRHTLEKMTDS------VTCLHCNSLAKQSKQSN 2261

  Fly  2247 -VAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKIN 2310
             :.|||.:|.:.:.:...:.               |.|    ||      .:..|..|:::
Mouse  2262 FLLVGTADGNLMIFEDKAVK---------------CKG----AA------PLKTLHIGDVS---- 2297

  Fly  2311 VFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGC--MVYQWD---VISKRIE 2370
             .||          :|.||..|           |:|.|:   .:.||  .|:.:.   .|.|.||
Mouse  2298 -TPL----------MCLSESLN-----------SSERHI---TWGGCGTKVFSFSNDFTIQKLIE 2337

  Fly  2371 NKLD------------------------------------------CSKLLPCSESLQSIAI--- 2390
            .|.:                                          | :|:.|...|:.:.:
Mouse  2338 TKTNQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKTEKLC-ELIDCVHFLKEVMVKLN 2401

  Fly  2391 --DEHVNLIKCQISALAAH-NSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITL---SK 2449
              .:|......::.||... |:.|:|||..|.:::.:|.|.|.|.....:.:.::::.|.   |.
Mouse  2402 KESKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGSL 2466

  Fly  2450 DNVPLIATIGRRYRS 2464
            .||.|:  :|.:.:|
Mouse  2467 KNVMLV--LGYKRKS 2479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560	15/88 (17%)
		ANK	146..286	CDD:238125	30/197 (15%)
		ANK repeat	146..177	CDD:293786	5/30 (17%)
		Ank_4	179..232	CDD:290365	10/56 (18%)
		ANK repeat	179..209	CDD:293786	7/33 (21%)
		Ank_2	216..389	CDD:289560	41/252 (16%)
		ANK	361..477	CDD:238125	33/178 (19%)
		ANK repeat	361..390	CDD:293786	9/28 (32%)
		Ank_2	364..464	CDD:289560	26/127 (20%)
		ANK repeat	406..435	CDD:293786	9/29 (31%)
		ANK repeat	437..464	CDD:293786	7/52 (13%)
		LRR_8	<544..580	CDD:290566	14/47 (30%)
		leucine-rich repeat	547..569	CDD:275380	10/27 (37%)
		LRR_8	569..629	CDD:290566	19/59 (32%)
		leucine-rich repeat	570..595	CDD:275380	8/24 (33%)
		leucine-rich repeat	596..618	CDD:275380	6/21 (29%)
		leucine-rich repeat	619..641	CDD:275380	5/23 (22%)
		leucine-rich repeat	642..676	CDD:275380	5/33 (15%)
		leucine-rich repeat	677..730	CDD:275380	12/59 (20%)
		LRR_8	729..788	CDD:290566	21/78 (27%)
		leucine-rich repeat	731..754	CDD:275380	10/42 (24%)
		LRR_8	855..933	CDD:290566	24/77 (31%)
		leucine-rich repeat	855..901	CDD:275380	13/45 (29%)
		leucine-rich repeat	902..924	CDD:275380	8/21 (38%)
		leucine-rich repeat	925..949	CDD:275380	8/23 (35%)
		P-loop_NTPase	993..1211	CDD:304359	66/230 (29%)
		COR	1230..1471	CDD:292713	69/246 (28%)
		STYKc	1796..2092	CDD:214568	94/308 (31%)
		STKc_LRRK	1801..2095	CDD:270902	96/302 (32%)
Lrrk2	NP_080006.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	957..979		5/21 (24%)
		LRR 1	983..1004		8/20 (40%)
		leucine-rich repeat	985..1012	CDD:275380	9/26 (35%)
		LRR 2	1012..1033		6/20 (30%)
		leucine-rich repeat	1013..1036	CDD:275380	7/22 (32%)
		LRR 3	1036..1057		7/22 (32%)
		leucine-rich repeat	1037..1059	CDD:275380	6/21 (29%)
		LRR 4	1059..1080		5/20 (25%)
		leucine-rich repeat	1060..1084	CDD:275380	5/23 (22%)
		LRR 5	1084..1105		8/49 (16%)
		leucine-rich repeat	1085..1108	CDD:275380	9/51 (18%)
		LRR 6	1108..1129		8/41 (20%)
		leucine-rich repeat	1109..1130	CDD:275380	8/41 (20%)
		LRR 7	1130..1151		6/20 (30%)
		leucine-rich repeat	1131..1170	CDD:275380	8/38 (21%)
		leucine-rich repeat	1171..1197	CDD:275380	6/25 (24%)
		LRR 8	1174..1195		5/20 (25%)
		LRR 9	1197..1218		10/73 (14%)
		leucine-rich repeat	1198..1221	CDD:275380	10/75 (13%)
		LRR 10	1221..1242		11/29 (38%)
		leucine-rich repeat	1222..1246	CDD:275380	13/45 (29%)
		LRR 11	1246..1267		7/20 (35%)
		LRR 12	1269..1291		6/21 (29%)
		leucine-rich repeat	1270..1291	CDD:275380	6/20 (30%)
		Gem1	1333..1551	CDD:224025	81/289 (28%)
		RocCOR	1334..1507	CDD:206741	69/241 (29%)
		COR	1527..1740	CDD:292713	78/321 (24%)
		STKc_LRRK2	1884..2135	CDD:270970	96/302 (32%)
		S_TKc	1884..2128	CDD:214567	93/295 (32%)
		WD 1	2139..2183		10/51 (20%)
		WD 2	2188..2228		11/39 (28%)
		WD 3	2233..2276		9/48 (19%)
		WD 4	2281..2327		18/99 (18%)
		WD 5	2333..2377		4/43 (9%)
		WD 6	2402..2438		9/35 (26%)
		WD 7	2443..2497		9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8227
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10820at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44229
orthoMCL	1	0.900	-	-		OOG6_105040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.680