DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and Map3k20

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_075544.1	Gene:	Map3k20 / 65964	MGIID:	2443258	Length:	802	Species:	Mus musculus

Alignment Length:	301	Identity:	76/301 - (25%)
Similarity:	123/301 - (40%)	Gaps:	70/301 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1803 GRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAY 1867
            |.|:||.|::|                                        ||.....:.:.|..
Mouse    23 GGGSFGSVYRA----------------------------------------KWISQDKEVAVKKL 47

  Fly  1868 CTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTL 1930
            ....:|..:|..|.|.||:...|:.::|  ..:|.|.|.||.|...:...|  ...|......|.
Mouse    48 LKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNR--SEEMDMEHIMTW 110

  Fly  1931 VLQAARAIEYLHRR---RIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGA 1992
            ....|:.:.|||..   ::|:|||||.||::       ..|..     :||.|:|.||....:..
Mouse   111 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVI-------AADGV-----LKICDFGASRFHNHTTH 163

  Fly  1993 KGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALT 2057
            ....||..:||||:|:   ....:|..|.:|:|:.::|.::...||:|.|.::...|...:   .
Mouse   164 MSLVGTFPWMAPEVIQ---SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEK---N 222

  Fly  2058 QRETQFPTCC----LDLMVLCWHEQPRRRPTASQIVSILSA 2094
            :|.| .|:.|    .:|:..||....::||:..||:|||.:
Mouse   223 ERLT-IPSSCPRSFAELLHQCWEADAKKRPSFKQIISILES 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	74/297 (25%)
		STKc_LRRK	1801..2095	CDD:270902	76/301 (25%)
Map3k20	NP_075544.1	STKc_MLTK	22..263	CDD:270962	76/301 (25%)
		Leucine-zipper	287..308
		SAM_MLTK	338..408	CDD:188928
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900