DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and map3k10

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	XP_689424.4	Gene:	map3k10 / 560932	ZFINID:	ZDB-GENE-050419-112	Length:	1062	Species:	Danio rerio

Alignment Length:	678	Identity:	154/678 - (22%)
Similarity:	240/678 - (35%)	Gaps:	251/678 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1674 LHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPD------------SAGSSR 1726
            |.|||..|...|..:                ..:.:|......|.||            |..|||
Zfish     7 LSGVGAGGGGSAAPL----------------PCISSGGSCGHLVPPDTQANTNSTPFLISINSSR 55

  Fly  1727 NTSV----DGHPGYHLP---DNSNVCY-------AWMIEEC------ILSVYNQ-SKIS------ 1764
            |:|.    .|.|..|||   ::||..:       |...||.      :|.|.:: ||:|
Zfish    56 NSSTIPSSVGSPDSHLPHHHESSNTYWTAVFDYEATADEELTLRRGDLLEVLSKDSKVSGDEGWW 120

  Fly  1765 ------------CPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKG--------------SLLG 1803
                        |....::..:..|             :|.|.::.|              .::|
Zfish   121 TGKIQDKVGIFPCNYVTQRDSSYPA-------------LPPEALVGGDSPLEIDFLELRLEEVIG 172

  Fly  1804 RGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGA-RAKESALMAFKVAVGKWDRDPLQHSCKAY 1867
            .|.||.|:|                        |. ||:|.|:.|.:       :||.:......
Zfish   173 AGGFGKVYK------------------------GVWRAEEVAVKAAR-------QDPDEDISATA 206

  Fly  1868 CTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTL 1930
            ...|||..:...|:|.||:.|.|:|::.  |.||:|.|..|.|:..|     :|..:.|......
Zfish   207 ENVRQEARLFWMLRHRNIIALRGVCLREPNLCLVMEYARGGALNRAL-----AGKKVPPRVLVNW 266

  Fly  1931 VLQAARAIEYLHRRR---IIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGA 1992
            .:|.|..::|||.:.   ||:|||||.|:|:.| |....:.|.:.|   ||.|:|::|:...:..
Zfish   267 AVQIATGMDYLHNQTFVPIIHRDLKSSNILILE-PVERDDLSGKTL---KITDFGLAREWHRTTK 327

  Fly  1993 KGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALT 2057
            ....||..:||||:|:.:   .:::..|.:|||:.::|.::...|:...:::  .:..|  .|:.
Zfish   328 MSAAGTYAWMAPEVIKLS---LFSKSSDVWSFGVLLWELLTGEVPYREIDAL--AVAYG--VAMN 385

  Fly  2058 QRETQFPTCC----LDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMP----HS----- 2109
            :.....|:.|    ..|:..||...||.||...   |||...|.|....:..||    ||
Zfish   386 KLTLPIPSTCPEAFAQLLGECWCPNPRGRPAFG---SILKRLEDIEQSAMFQMPLESFHSLQEDW 447

  Fly  2110 --------------EK--------------------------------------------IVCGV 2116
                          ||                                            |:..:
Zfish   448 RLEIQQMFDELRAKEKELRSWEEALARAAEEQREQEEHLRRREQELAEREIDIVERELNIIIHQM 512

  Fly  2117 FQS---------------LVGMGDDERCGLELWLPS-FGSRIDILDCSPSGSLLQCNSISCSPQP 2165
            :|.               |:.:|.|..|   :.||| |..:|.: ..|||....:|.| |.|..|
Zfish   513 YQEKPQVKKRKGNFKKSRLLKLGRDSNC---ISLPSGFEHKITV-QASPSVDKRKCQS-SESTTP 572

  Fly  2166 QVAP---PK------TPENGANSRARSA 2184
            ..:|   |:      ||.:|..:..|:|
Zfish   573 PASPGVIPRLRAFRLTPSDGRKTWGRTA 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	83/319 (26%)
		STKc_LRRK	1801..2095	CDD:270902	84/303 (28%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992	9/56 (16%)
		STYKc	165..424	CDD:214568	84/308 (27%)
		STKc_MLK2	170..427	CDD:271050	85/306 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900