DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and lrrk2

DIOPT Version :10

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:XP_068073486.1 Gene:lrrk2 / 559366 ZFINID:ZDB-GENE-071218-6 Length:2672 Species:Danio rerio


Alignment Length:2713 Identity:603/2713 - (22%)
Similarity:990/2713 - (36%) Gaps:842/2713 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 ASWAPTCAVRHKTAWINDHKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTVRVLLAALGTE 133
            |.||....:.|    .|...||.:         |.|...|..:..|::. ...:|:|..||..|.
Zfish   406 ACWALNSLLLH----CNTSNNVEL---------EGRPPLHTLIMAAMLL-HSSSVKVFQAASSTL 456

  Fly   134 RQIIVN----MAPSGANTLLF-------------LACQSGYESITQRLLDAGADGRSHAVTKYSP 181
            |.:|..    .:|..:|.:.|             ..|:|..:.|             |  |.:..
Zfish   457 RTLIQRHCRIRSPLLSNGIHFNIVELMRKHPNSSAVCESACKLI-------------H--TLFQG 506

  Fly   182 LYAAVHSGHLGIARLML-----DHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPD--- 238
            ..|::..|.|.::::::     :..|| :|...:...|.|    :|....|.|..:|.:.||   
Zfish   507 ARASLDDGFLILSQILIALKTHNFLPE-VQLEGLRASLVL----LNPDRSLREHGVSVADPDMVD 566

  Fly   239 ------------------YLYQTYR--DEEGQWEWRLPFDANAHDVTGQTSLY-----IASILGN 278
                              ||....|  ..|...|..|...|...|.:|...|.     |.::|..
Zfish   567 VSLQVLKNQCVLEGAHTVYLQALNRFISSESIQECGLGVLAALADSSGAVDLMCQQGAIDTVLHT 631

  Fly   279 KQLV---------GVLLKWQLHCRRTLGDSASSV--STPITPTRKR------ISFGIQAIMSKLH 326
            .|:.         |:.|.:.|..::.|......|  |..::..||.      :..|:|.:...|.
Zfish   632 LQMFPQERDIHYWGLSLLFHLISKKKLSRMMVPVLASVLVSSVRKHKEDSVMLLKGLQVVWKLLD 696

  Fly   327 ISG------ESEGPD----DLASQESTECQRCPI-NVNLLCGAARET------ALL-AAVRGGHL 373
            ...      :.|..:    .:..:.:.:.:|.|: .::.||.:...|      ||| .|...|.:
Zfish   697 TCSSAAVWLQKEAFEKEIFQILRENTADQRRDPLQGMSCLCLSKMVTDGEILYALLERACEDGDV 761

  Fly   374 DVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRS-LAMLDLLLKHGAR--- 434
            |:.:.|:|.||:.|...|                 |:..:.:||.:.: ||:|:||:..|..   
Zfish   762 DMAECLIQLGADVNKKTK-----------------SDSLLYQACDRGAPLALLELLVSSGVHEQH 809

  Fly   435 ------------DDNGTAI----------GMAITCGDEAI-------LSRLLARRVHPDSDYKIN 470
                        ||....:          ..|:..|...|       :|.||:.|....::...:
Zfish   810 LRGALSVCVRRSDDPAVTLILRRLGLDHTNSALCLGSVRIGHMKASWISALLSERRSQSTNTHYS 874

  Fly   471 KKGLPTPVEVNVFLPS---------TSNISYSAMFPNNPTIIDWH---------------SMGS- 510
            .||.....:::.....         :|::|.|..|.:..: .|.|               |.|| 
Zfish   875 SKGQRLARQISQLQRKKGIVGVSRLSSDVSTSGYFTDEES-DDSHISLEDSLVFMFDELESDGSD 938

  Fly   511 ---------SVQLSVVRVP-WMVSGVLLLNPKLQSHPR--------------------------- 538
                     |..|.|.|.| |          :.:||.|                           
Zfish   939 GPPHGFMLISDSLEVSRRPVW----------RRRSHSRRTSSEGYHGEADPSVPVQKHANSHNIR 993

  Fly   539 --------LNEVAL--TAITRIDFSHNVLTSIP-----QELFHLV-SLRYLNVAQNKITDLPAPI 587
                    .:.|.|  ..:..:|.|.|.|..:.     ..|..|: :|..|:::.|.::..|:.:
Zfish   994 GQGFSESFSSPVVLDKDPVRLLDLSGNELNDLSCLTDLNSLKKLIENLHRLDLSGNNLSQFPSIL 1058

  Fly   588 GQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNN---KLQQLPFDLWRAPKLRELNVAF 649
            .|:...  |..|.||.|.|..||:.:..||||..|:||.|   .|.||...:. :|.||.||::|
Zfish  1059 CQSLRS--LTRLDLQGNHLQCLPSELLSLPALHTLNVSRNCIGPLLQLEPGVC-SPALRRLNLSF 1120

  Fly   650 NLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQH 714
            |   .:.|.|.|..|:...|::|:|:..:....:.|..:.:.::         ||::.|.:|...
Zfish  1121 N---QITVCPFQLRSATQRLEELSLEGNQISELSLPLCLAELKV---------LDVSKNQVKIVS 1173

  Fly   715 EQDLGD---GKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPA 776
            :..|.:   .:|.....:|:||              ||.|...:|.:.:|:|:...:..:.....
Zfish  1174 DNFLAECLKMETFIASVNQISS--------------LPHLPSKITTVKLSHNTFTRVPEIVINLP 1224

  Fly   777 TLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLK 841
            .|:.:|:.:|.:...|.                                           .||..
Zfish  1225 CLRSVDMRNNSVGVLPG-------------------------------------------PSVWL 1246

  Fly   842 SVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLD 906
            ||          .||.|:.:.||::.:.||          .....|:            .|..|.
Zfish  1247 SV----------NLRELMFSHNLISALDLS----------GPVYKWA------------RLEKLH 1279

  Fly   907 MTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKK 971
            ::.|.|.|||..:..|..|:.|::|.|..:...|..:|.|..||:|...|..||..|       |
Zfish  1280 LSFNRLTEIPPQIGMLEDLTSLDVSHNEGLRSFPDEMGKLVHLWDLPLDGLQLQLDL-------K 1337

  Fly   972 H---KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASEN 1033
            |   ||.||:.:|:...:.|.||.||||||:|.:|.|||:|:..|              .|...:
Zfish  1338 HIGSKTKDIIRFLQQRLKKAVPYHRMKLMVLGGSGSGKSSLIQQL--------------MRLRRS 1388

  Fly  1034 HWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW-ICEKRKRAPGSHGPVVFRTWDFGGQKEY 1097
            .|.                       |..||.|..| :..|.||      .::...|:|.|.:|.
Zfish  1389 QWR-----------------------SDPGVSIRDWPVRSKDKR------NMMLNVWEFSGGEEC 1424

  Fly  1098 YATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKA 1162
            ...|.:|:|.|::||||:.:|.|...:..:..||.||:|.|...|||:||||.|...|....:..
Zfish  1425 SGIHPHFMSSRAVYLVLYDLSKGASEIHAIKPWLFNIKAVAGQCPVIVVGTHADLCEERHLQECL 1489

  Fly  1163 EQLQQLIREKFIAIPDAEKIGLPRVIDSIEIS-CRTLHNIHLLANIIYDTAMQLRSPGSKEPMLL 1226
            .:||:.::.:    |     |.|.:.::..:| |....::..|...||...:..:..|  :|::.
Zfish  1490 LKLQKELQSQ----P-----GFPAIRENHVLSACEESESLGRLRKAIYRELIGFKIQG--QPVMG 1543

  Fly  1227 QKIPASYIALED-IVNVIACNLRAAGRDPVLDGEQYKRLVTE-QMRLHNYKSFRDAAELQQATTW 1289
            |.:|..|:.||. ::...:|   |....|||...:...::.| |::|       :..||..|..:
Zfish  1544 QLVPDCYVELEKRLLQERSC---APADFPVLRHSRLMEILQETQLQL-------EEGELPHAIHF 1598

  Fly  1290 CHENGVLLHYDDA-TLRDYYFLDPQWLCDMLAHVVTVREINPFAPT-GVMKLDDLQMLFRSVQVQ 1352
            ..|.|||||:|.. .|:|.||:|.||.|.:::..::::...|:..| ||::...::......:..
Zfish  1599 LSEAGVLLHFDPVLQLKDLYFIDLQWFCRIISQTLSLKSSGPWDSTKGVVQRSTVEKFVEKSRCF 1663

  Fly  1353 GNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEV 1417
            ...:......||.||::||.:|...|||||.|....       ..::|                 
Zfish  1664 PKDHMIQYFKLLEKFQIALPFDHDQLLIPSSLSDHR-------PVIEL----------------- 1704

  Fly  1418 NLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQ 1482
                        |...:|...:     |:..|.|||.|:|.|.|:|:|                 
Zfish  1705 ------------PHCENSEVII-----RLYEMPYFPMGYWPRQISRLL----------------- 1735

  Fly  1483 DYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIW 1547
                                :....|.||             :.:..:|     ||...:: ||:
Zfish  1736 --------------------EVSAFLLYG-------------REKALKP-----NRIYWRK-GIY 1761

  Fly  1548 SDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPS 1612
            ...:..:..::|          :..:::|....:....|...:...|....|||||.|||:|:|.
Zfish  1762 LSWSAEAYCLVE----------ALTLEENPASFIKITVPCSRKGRVLFGQVVDHIDSLLEEWFPG 1816

  Fly  1613 LGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGV 1677
            |.|..:| ..|..|:.:        |                                       
Zfish  1817 LLTTDIH-GTGETLLKK--------W--------------------------------------- 1833

  Fly  1678 GDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNS 1742
                   ||..||...|.   ::...||.|.                  ||:.||          
Zfish  1834 -------ALYSFSDGQNC---QKMLLEDLLS------------------NTNADG---------- 1860

  Fly  1743 NVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSEC----IIKGSLLG 1803
                         .:.|....||.:    .::|::||::.:|.|....:..|.    :....:||
Zfish  1861 -------------LLVNPEDPSCTL----PISQISPDLVLSDQPSSTILDPEQLEMELTAEYMLG 1908

  Fly  1804 RGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYC 1868
            .|.||.|:||..|      .:.||:|:..                            :|:...|.
Zfish  1909 DGGFGSVYKAVYK------NEEVAVKIFN----------------------------KHASALYV 1939

  Fly  1869 --TARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLV 1931
              ..|||||||..|.||::|.|:.....|..||:||||.|.||:|   :.|....:.......:.
Zfish  1940 HRLVRQELAVLGRLCHPSLVGLLAAGCNPHILVMELAPYGSLDSL---FERENGSLSRKLQHRIA 2001

  Fly  1932 LQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFG 1996
            |..|..::|||...|||||||..|||::.|    ..|:.   :..||.||||::.....|.:...
Zfish  2002 LHVADGLKYLHSSMIIYRDLKPHNVLLFNL----KTDAE---IVAKITDYGIAQYCCSMGVRSSE 2059

  Fly  1997 GTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIY------ENIS--LRQPFEGHESIKECILEGSR 2053
            ||.||.|||:.|  |...|..:.|.:|||:.:|      |.||  ::.|.|    ..|..::|..
Zfish  2060 GTPGFRAPEVAR--GNVIYNVQADVYSFGLLLYDLLTYGERISDGMKFPSE----FDEVAVQGKL 2118

  Fly  2054 PALTQRETQFPTCCLD-LMVLCWHEQPRRRPTASQIVSILSAPECIHL---LDVVAMPHSEKIVC 2114
            |...:.....|...:: ||..|..|.|:.|||::|:...|::.|.:.|   |:||..|..    |
Zfish  2119 PDPVKDYGCSPWPEIESLMRECMRENPQDRPTSAQVFDRLNSAEMLCLMRELNVVGFPGE----C 2179

  Fly  2115 GVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANS 2179
            .|..:..|..:..: ...:|:.. ||....|.|..:..|                    |.|.:.
Zfish  2180 FVVSNSGGAANGGK-NPHVWIGG-GSSSQKLGCVTAVDL--------------------ETGGSL 2222

  Fly  2180 RARSAQRLPKMNMLCCCLVGEA----IWM--GDVSGNLHAYST--STYAHLFSYMLDPNIKSAVI 2236
            .    |.|.:..:||..::..|    .|:  |..||:|....|  :...|...     ::|.:|.
Zfish  2223 N----QELDRSPILCMVIIRAADSCSDWLVAGSESGSLFIMDTINAKVLHRLK-----SVKDSVT 2278

  Fly  2237 SLVYMEKI------ARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLT-EI--------CSGFVL 2286
            ||.:..::      :.:.|||.:|.:.:.:    .|......|..|.| |:        |.|...
Zfish  2279 SLYFHTELQHRCLKSYLLVGTADGTLVIYE----DSALKVENGGPVKTLEVGDVNTPLMCLGPSS 2339

  Fly  2287 H--------AACS--VVVDGIYELWCGEIAGKIN-VFPLNENGVSGHQALCHSEEPNLIEDVKVA 2340
            |        |||.  :::..:....|..|..|.. :|.|... |||              :..::
Zfish  2340 HPQERRSLWAACGTRIILFTVEFDVCRSIDTKPKPLFSLQAR-VSG--------------EACIS 2389

  Fly  2341 RMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDEHVN-------LIK 2398
            |: :.:.||:.....|..|..||..::|:.|.:||.:||..|.:.:.....|..:       ::|
Zfish  2390 RL-AVDKHVYVSKTGGHTVEVWDKKTERMVNLIDCMQLLGLSSTRKPKVHSEDQSRPMVPSLVVK 2453

  Fly  2399 CQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIK---SII--TLSKDNVPLIATI 2458
               :.|..|:..|:|||..|.:::.|:.:...:....|:.:.|:   ||:  ||::.||.|:  :
Zfish  2454 ---ALLVQHSGTLWIGTRAGHILLVEVSSCHLLQTINPHCHSIRCMGSILLDTLNRKNVILV--L 2513

  Fly  2459 GRRYRSLISRYVDSAESSTKSSAVSTPTH-GAAKSVPPADVDNHIHCL 2505
            |||.|.    :::..::.::...|||.:| ....::.|     |||.|
Zfish  2514 GRRQRI----HLEQLKTQSEGFLVSTLSHQNRTWTIHP-----HIHRL 2552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430 51/267 (19%)
ANK repeat 146..177 CDD:293786 6/43 (14%)
ANK repeat 179..209 CDD:293786 6/34 (18%)
ANK repeat 361..390 CDD:293786 12/35 (34%)
Ank_2 364..465 CDD:463710 29/134 (22%)
ANK repeat 406..435 CDD:293786 9/44 (20%)
ANK repeat 437..464 CDD:293786 7/43 (16%)
LRR <544..>768 CDD:443914 61/237 (26%)
leucine-rich repeat 547..569 CDD:275380 6/27 (22%)
leucine-rich repeat 570..595 CDD:275380 5/24 (21%)
leucine-rich repeat 596..618 CDD:275380 9/21 (43%)
leucine-rich repeat 619..641 CDD:275380 8/24 (33%)
leucine-rich repeat 642..676 CDD:275380 13/33 (39%)
leucine-rich repeat 677..730 CDD:275380 7/55 (13%)
leucine-rich repeat 731..754 CDD:275380 5/22 (23%)
LRR_8 855..933 CDD:404697 19/77 (25%)
leucine-rich repeat 855..901 CDD:275380 8/45 (18%)
LRR_4 900..941 CDD:463713 12/40 (30%)
leucine-rich repeat 902..924 CDD:275380 8/21 (38%)
leucine-rich repeat 925..949 CDD:275380 7/23 (30%)
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819 62/219 (28%)
COR 1230..>1393 CDD:406489 47/166 (28%)
STKc_LRRK 1801..2095 CDD:270902 96/304 (32%)
lrrk2XP_068073486.1 LRR 1007..>1263 CDD:443914 74/337 (22%)
leucine-rich repeat 1041..1064 CDD:275380 5/22 (23%)
leucine-rich repeat 1065..1087 CDD:275380 9/21 (43%)
leucine-rich repeat 1088..1112 CDD:275380 8/24 (33%)
leucine-rich repeat 1113..1136 CDD:275380 10/25 (40%)
leucine-rich repeat 1137..1158 CDD:275380 4/20 (20%)
leucine-rich repeat 1159..1198 CDD:275380 10/61 (16%)
leucine-rich repeat 1199..1225 CDD:275380 4/25 (16%)
leucine-rich repeat 1226..1249 CDD:275380 8/75 (11%)
leucine-rich repeat 1275..1298 CDD:275380 8/22 (36%)
P-loop containing Nucleoside Triphosphate Hydrolases 1362..1530 CDD:476819 62/219 (28%)
COR 1550..1762 CDD:406489 68/318 (21%)
Protein Kinases, catalytic domain 1906..2161 CDD:473864 96/304 (32%)

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