Protein Alignment Lrrk and PBK

DIOPT Version :9

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_001265874.1
• Gene: PBK / 55872
• HGNCID: 18282
• Length: 333
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 79/346 - (22%)
• Similarity: 133/346 - (38%)
• Gaps: 89/346 - (25%)

  Fly  1791 IPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKW 1855
            ||:...::....|.|...::.|.:  .||. |..|.|:|.:.|:
Human    29 IPASPFMQKLGFGTGVNVYLMKRS--PRGL-SHSPWAVKKINPI--------------------- 69

  Fly  1856 DRDPLQHSCKAYCTA------RQELAVLLTLKHPNIVPLVGICIK---PLALVLELAPLGGLDAL 1911
                    |..:..:      ..|..:|.:|.|||||........   .|.|.:|......|:.|
Human    70 --------CNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDL 126

  Fly  1912 L-RHYRRSGAHMGPHTFQTLVLQAARAIEYLHR-RRIIYRDLKSENVLVWELPQPHTEDSPRNLV 1974
            : ..|:.|...........:.|..||.::|||: :::::.|:||.||::           ..:..
Human   127 IEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVI-----------KGDFE 180

  Fly  1975 HIKIADYGIS-----RQTAPS-----------GAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFS 2023
            .|||.|.|:|     ..|||:           ....:.|||.:...|.:..||  ..|:|.|.|:
Human   181 TIKICDVGVSLPLDENMTAPAFITILLVSVTDPEACYIGTEPWKPKEAVEENG--VITDKADIFA 243

  Fly  2024 FGMFIYENISLRQP--------------FEGHESIKECILE--GSRPALTQRE-TQFPTCCLDLM 2071
            ||:.::|.::|..|              |:..:...|....  |:||.:...| .:.....::|.
Human   244 FGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELF 308

  Fly  2072 VLCWHEQPRRRPTASQIVSIL 2092
            .:|.:|.|:.||:|:.||..|
Human   309 SVCTNEDPKDRPSAAHIVEAL 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	76/339 (22%)
		STKc_LRRK	1801..2095	CDD:270902	77/336 (23%)
PBK	NP_001265874.1	PKc_TOPK	32..332	CDD:270903	77/343 (22%)
		Pkinase	34..327	CDD:278497	75/337 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900