DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and RIPK4

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_065690.2	Gene:	RIPK4 / 54101	HGNCID:	496	Length:	784	Species:	Homo sapiens

Alignment Length:	784	Identity:	176/784 - (22%)
Similarity:	287/784 - (36%)	Gaps:	218/784 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866
            :|.|.||.|:    |||.......:|:|....:....|.:...|...|
Human    28 VGSGGFGQVY----KVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAK----------------- 71

  Fly  1867 YCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLR--------HYRRSGAHMG 1923
                :.|:|     |...|:|:.|||.:|:.||:|....|.|:.||.        .:|
Human    72 ----KMEMA-----KFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFR------- 120

  Fly  1924 PHTFQTLVLQAARAIEYLH--RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQ 1986
                  ::.:.|..:.:||  ...:::.|||..|:|:    ..|        .|:||:|:|:::.
Human   121 ------IIHETAVGMNFLHCMAPPLLHLDLKPANILL----DAH--------YHVKISDFGLAKC 167

  Fly  1987 TAPS-----GAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKE 2046
            ...|     ...|..||..::.||.|| .....:..|.|.:||.:.|:..::.::||...::|..
Human   168 NGLSHSHDLSMDGLFGTIAYLPPERIR-EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILH 231

  Fly  2047 C---ILEGSRPALTQRETQFPTCC---LDLMVLCWHEQPRRRPTASQIVS----ILSAP-----E 2096
            .   :::|.||.|.......|..|   :.||..||...||.|||..:|.|    :...|     |
Human   232 IMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEVKE 296

  Fly  2097 CIHLLDVVAMPHSEKIV---------------------------CGVFQSLVGMGDDERCGLELW 2134
            ..|.|||.:.|.....|                           .||.|::.|..:..|...|..
Human   297 TAHDLDVKSPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESK 361

  Fly  2135 LPSFG-----SRIDILDC--SPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNM 2192
            |||.|     |.:..:|.  |..|||    |:|...:|..:...|.:            :.|..:
Human   362 LPSSGSGKRLSGVSSVDSAFSSRGSL----SLSFEREPSTSDLGTTD------------VQKKKL 410

  Fly  2193 LCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVF 2257
            :      :||..||.|            .|...:...::..|:.|...:..:| |..|......:
Human   411 V------DAIVSGDTS------------KLMKILQPQDVDLALDSGASLLHLA-VEAGQEECAKW 456

  Fly  2258 LVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSG- 2321
            |:.....| |.:...||         ..||.|....|.|:.||.   :|.||:|...:|:..:.
Human   457 LLLNNANP-NLSNRRGS---------TPLHMAVERRVRGVVELL---LARKISVNAKDEDQWTAL 508

  Fly  2322 HQALCHSEEPN---LIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCS-----KL 2378
            |.|..:.:|.:   |:|  |.|.:...:....:.::..|...|.:::...:...:|.|     ..
Human   509 HFAAQNGDESSTRLLLE--KNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAW 571

  Fly  2379 LPCSESLQSIAIDEHVNLIKCQISALAAH-----NSELYIGTTWGCLIVAELHTLRPISVFRPYE 2438
            ||    |...|...|:.::|    .||..     |::...|.|       .||    ::..|.:.
Human   572 LP----LHYAAWQGHLPIVK----LLAKQPGVSVNAQTLDGRT-------PLH----LAAQRGHY 617

  Fly  2439 NEIKSIITLSKD-NVPLIATIGRRYRSLISR---YVDSAESSTKSSAVSTPTHGAAKSVPPADVD 2499
            ...:.:|.|..| ||          .||:::   :| :||:...|:|......||.|....:|..
Human   618 RVARILIDLCSDVNV----------CSLLAQTPLHV-AAETGHTSTARLLLHRGAGKEAMTSDGY 671

  Fly  2500 NHIH 2503
            ..:|
Human   672 TALH 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	77/314 (25%)
		STKc_LRRK	1801..2095	CDD:270902	77/317 (24%)
RIPK4	NP_065690.2	STKc_RIP4_like	25..290	CDD:270927	77/317 (24%)
		STYKc	26..279	CDD:214568	75/306 (25%)
		ANK	413..524	CDD:238125	31/136 (23%)
		ANK repeat	437..468	CDD:293786	7/32 (22%)
		Ank_2	442..534	CDD:289560	27/107 (25%)
		ANK repeat	470..501	CDD:293786	13/42 (31%)
		ANK	471..589	CDD:238125	31/139 (22%)
		ANK repeat	503..534	CDD:293786	7/32 (22%)
		Ank_2	508..600	CDD:289560	20/101 (20%)
		ANK repeat	536..567	CDD:293786	4/30 (13%)
		ANK repeat	569..600	CDD:293786	9/38 (24%)
		ANK	598..723	CDD:238125	23/100 (23%)
		ANK repeat	603..634	CDD:293786	10/51 (20%)
		Ank_2	608..699	CDD:289560	20/83 (24%)
		ANK repeat	636..667	CDD:293786	8/31 (26%)
		ANK repeat	669..699	CDD:293786	2/7 (29%)
		Ank_2	674..764	CDD:289560	1/2 (50%)
		ANK	729..>764	CDD:238125
		ANK repeat	734..764	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900