| Sequence 1: | NP_001262772.1 | Gene: | Lrrk / 42447 | FlyBaseID: | FBgn0038816 | Length: | 2513 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_057062.1 | Gene: | TNNI3K / 51086 | HGNCID: | 19661 | Length: | 835 | Species: | Homo sapiens |
| Alignment Length: | 974 | Identity: | 186/974 - (19%) |
|---|---|---|---|
| Similarity: | 307/974 - (31%) | Gaps: | 380/974 - (39%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 1320 AHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYI----VSLLN--------KFEVALT 1372
Fly 1373 WDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSS--SS 1435
Fly 1436 SASVSQ----GLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQD 1496
Fly 1497 TQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVY 1561
Fly 1562 FPLYEVNISQEVDDNERQLLAEIRP-HMS------QVAKLLALTVDHIDLLL---EDWYP-SLGT 1615
Fly 1616 RFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDP 1680
Fly 1681 GE--------DGALNVFSAYLNATARRERRSED-----------SLGAGSDADSGVGPDSAGSSR 1726
Fly 1727 NTSVDGHPGYH-------------LPDN-------------------SNVCYAWMIEE------C 1753
Fly 1754 ILSVYN--QSKISC-----------------PVHLEQSMAQLAPDVIF--ADIPDKHTIPSECII 1797
Fly 1798 KGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQH 1862
Fly 1863 SCKAYCTAR------QELAVLLTLKHPNIVPLVGICI---KPLALVLELAPLGGLDALLRHYRRS 1918
Fly 1919 GAHMGPHTFQTLVLQAARAIEYLHR--RRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADY 1981
Fly 1982 GISRQTAPSGAKGFGGTEG---FMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHES 2043
Fly 2044 IKECILEGSRPALTQRETQF-----------PTCCLDLMVLCWHEQPRRRPTASQIVSILSAPEC 2097
Fly 2098 IHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISC 2161 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Lrrk | NP_001262772.1 | Ank_2 | 111..200 | CDD:289560 | |
| ANK | 146..286 | CDD:238125 | |||
| ANK repeat | 146..177 | CDD:293786 | |||
| Ank_4 | 179..232 | CDD:290365 | |||
| ANK repeat | 179..209 | CDD:293786 | |||
| Ank_2 | 216..389 | CDD:289560 | |||
| ANK | 361..477 | CDD:238125 | |||
| ANK repeat | 361..390 | CDD:293786 | |||
| Ank_2 | 364..464 | CDD:289560 | |||
| ANK repeat | 406..435 | CDD:293786 | |||
| ANK repeat | 437..464 | CDD:293786 | |||
| LRR_8 | <544..580 | CDD:290566 | |||
| leucine-rich repeat | 547..569 | CDD:275380 | |||
| LRR_8 | 569..629 | CDD:290566 | |||
| leucine-rich repeat | 570..595 | CDD:275380 | |||
| leucine-rich repeat | 596..618 | CDD:275380 | |||
| leucine-rich repeat | 619..641 | CDD:275380 | |||
| leucine-rich repeat | 642..676 | CDD:275380 | |||
| leucine-rich repeat | 677..730 | CDD:275380 | |||
| LRR_8 | 729..788 | CDD:290566 | |||
| leucine-rich repeat | 731..754 | CDD:275380 | |||
| LRR_8 | 855..933 | CDD:290566 | |||
| leucine-rich repeat | 855..901 | CDD:275380 | |||
| leucine-rich repeat | 902..924 | CDD:275380 | |||
| leucine-rich repeat | 925..949 | CDD:275380 | |||
| P-loop_NTPase | 993..1211 | CDD:304359 | |||
| COR | 1230..1471 | CDD:292713 | 30/168 (18%) | ||
| STYKc | 1796..2092 | CDD:214568 | 75/320 (23%) | ||
| STKc_LRRK | 1801..2095 | CDD:270902 | 74/318 (23%) | ||
| TNNI3K | NP_057062.1 | ANK | <56..121 | CDD:238125 | 17/93 (18%) |
| ANK repeat | 66..98 | CDD:293786 | 10/39 (26%) | ||
| ANK 1 | 66..96 | 9/35 (26%) | |||
| ANK | 99..220 | CDD:238125 | 37/216 (17%) | ||
| ANK repeat | 100..131 | CDD:293786 | 7/51 (14%) | ||
| ANK 2 | 100..129 | 6/49 (12%) | |||
| ANK 3 | 133..162 | 5/39 (13%) | |||
| ANK repeat | 134..164 | CDD:293786 | 5/40 (13%) | ||
| ANK | 161..290 | CDD:238125 | 44/231 (19%) | ||
| ANK repeat | 166..197 | CDD:293786 | 13/85 (15%) | ||
| ANK 4 | 166..195 | 12/83 (14%) | |||
| ANK repeat | 199..232 | CDD:293786 | 10/41 (24%) | ||
| ANK 5 | 199..228 | 9/37 (24%) | |||
| ANK | 229..360 | CDD:238125 | 25/169 (15%) | ||
| ANK 6 | 234..263 | 11/48 (23%) | |||
| ANK repeat | 234..262 | CDD:293786 | 10/47 (21%) | ||
| ANK repeat | 269..302 | CDD:293786 | 3/32 (9%) | ||
| ANK 7 | 269..298 | 3/28 (11%) | |||
| ANK repeat | 304..337 | CDD:293786 | 2/32 (6%) | ||
| ANK 8 | 304..335 | 2/30 (7%) | |||
| ANK | 334..>401 | CDD:238125 | 11/66 (17%) | ||
| ANK repeat | 339..369 | CDD:293786 | 8/29 (28%) | ||
| ANK 9 | 339..368 | 8/28 (29%) | |||
| ANK 10 | 381..410 | 6/28 (21%) | |||
| PKc_TNNI3K | 469..722 | CDD:270966 | 74/319 (23%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 732..751 | 6/25 (24%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0192 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||