Protein Alignment Lrrk and slpr

DIOPT Version :10

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Alignment Length: 342
• Identity: 92/342 - (26%)
• Similarity: 145/342 - (42%)
• Gaps: 67/342 - (19%)

  Fly  1766 PVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKV-RGARSFKPVAMK 1829
            |:.|..|.|       ..||.......:|..|| .::|.|.|       ||| ||....:.||:|
  Fly   107 PLQLNVSSA-------IGDIQPHEIEYNELDIK-EVIGSGGF-------CKVHRGYYDGEEVAIK 156

  Fly  1830 MLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIK 1894
            :..                  ..|:.|...::.:      ..||..:...|||.||..|.|:|:.
  Fly   157 IAH------------------QTGEDDMQRMRDN------VLQEAKLFWALKHENIAALRGVCLN 197

  Fly  1895 -PLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRR---RIIYRDLKSEN 1955
             .|.||:|.|..|.|:.:|      ...:.|.......:|.||.:.|||..   .||:|||||.|
  Fly   198 TKLCLVMEYARGGSLNRIL------AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSN 256

  Fly  1956 VLVWE-LPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKV 2019
            ||::| :...|.:...     :||.|:|::|:...:......||..:|.||:|..:   .|::..
  Fly   257 VLIYEAIEGNHLQQKT-----LKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVS---TYSKFS 313

  Fly  2020 DCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLD----LMVLCWHEQPR 2080
            |.:|:|:.::|.|:...|::|.:.:.  :..|  .|:.......|..|.:    ||..||...|.
  Fly   314 DVWSYGVLLWELITGETPYKGFDPLS--VAYG--VAVNTLTLPIPKTCPETWGALMKSCWQTDPH 374

  Fly  2081 RRPTASQIVSILSAPEC 2097
            :||...:|:..|.:..|
  Fly   375 KRPGFKEILKQLESIAC 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	82/303 (27%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	82/303 (27%)