DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and Tnni3k

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_796040.3 Gene:Tnni3k / 435766 MGIID:2443276 Length:834 Species:Mus musculus


Alignment Length:761 Identity:153/761 - (20%)
Similarity:246/761 - (32%) Gaps:306/761 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  1541 LKQDGIWSDVNLSSSSILEVYF-PLY-------------------EVNISQEVDDNERQLLAEIR 1585
            |.|.|  ::||:..:    |:| ||:                   :||:|.||.|         |
Mouse   153 LLQHG--ANVNVQDA----VFFTPLHIAAYYGHEQVTSVLLKFGADVNVSGEVGD---------R 202

  Fly  1586 P-HMS------QVAKLLAL----------TVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLC 1633
            | |::      .:.|||..          ..||:.|       ...:||.|.:...:|:      
Mouse   203 PLHLASAKGFFNIVKLLVEGNKADVNAQDNEDHVPL-------HFCSRFGHHNIVSYLL------ 254

  Fly  1634 PRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGE--------DGALNVFS 1690
                          .||.||.|                   |.:...|:        :|...|..
Mouse   255 --------------QSDLEVQP-------------------HVINIYGDTPLHLACYNGNFEVAK 286

  Fly  1691 AYLNATARRERRSED-----------SLGAGSDADSGVGPDSAGSSRNTSVDGHPGYH------- 1737
            ..::.|.......|:           :.|...|....:...:|.:..:...|||.|.|       
Mouse   287 EIVHVTGTESLTKENIFSETAFHSACTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACYHGH 351

  Fly  1738 ------LPDN-------------------SNVCYAWMIEE------CILSVYN--QSKISC---- 1765
                  |.||                   ...|..|..|:      .:|..|.  |.::.|    
Mouse   352 IRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYS 416

  Fly  1766 -------------PVHLEQSMAQLAPDVIF--ADIPDKHTIPSECIIKGSLLGRGAFGFVFKANC 1815
                         |:...:||.:...||:.  |::|.:..:....|....::|.|:||.|:|..|
Mouse   417 QPGGDGSYVSVPSPLGKIKSMTKEKADVLLLRAELPSRFHLQLSEIEFHEIIGSGSFGKVYKGRC 481

  Fly  1816 KVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTAR------QEL 1874
            :      .|.||:|                               ::....||:..      :|:
Mouse   482 R------NKIVAIK-------------------------------RYRANTYCSKSDVDMFCREV 509

  Fly  1875 AVLLTLKHPNIVPLVGICI---KPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAAR 1936
            ::|..|.||.:|..||.|:   ...|:|.:....|.|.:||...:|.   :...:...:.:..|:
Mouse   510 SILCQLNHPCVVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRI---LDLQSKLIIAVDVAK 571

  Fly  1937 AIEYLH--RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTE 1999
            .:||||  .:.||:|||.|.|:|::       ||.     |..:||:|.||..............
Mouse   572 GMEYLHSLTQPIIHRDLNSHNILLY-------EDG-----HAVVADFGESRFLQSLDEDNMTKQP 624

  Fly  2000 G---FMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRET 2061
            |   :||||:  :.....||.|.|.||:.:.::|.::...|| .|          .:||....:.
Mouse   625 GNLRWMAPEV--FTQCTRYTIKADVFSYALCLWELLTGEIPF-AH----------LKPAAAAADM 676

  Fly  2062 QF-----------PTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCG 2115
            .:           |.....|::..|:..|..||..|::|..|.  ||:                 
Mouse   677 AYHHIRPPIGYSIPKPISSLLMRGWNACPEGRPEFSEVVRKLE--ECL----------------- 722

  Fly  2116 VFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISC 2161
                         |.:||..|:        ..:.||||...:|..|
Mouse   723 -------------CNVELMSPA--------SSNSSGSLSPSSSSDC 747

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568 76/320 (24%)
STKc_LRRK 1801..2095 CDD:270902 76/318 (24%)
Tnni3kNP_796040.3 ANK repeat 66..98 CDD:293786
ANK 1 66..96
Ank_2 71..164 CDD:289560 5/12 (42%)
ANK 99..220 CDD:238125 20/81 (25%)
ANK repeat 100..131 CDD:293786
ANK 2 100..129
ANK 3 133..162 4/10 (40%)
ANK repeat 134..164 CDD:293786 5/12 (42%)
Ank_2 138..231 CDD:289560 21/92 (23%)
ANK 161..289 CDD:238125 33/186 (18%)
ANK repeat 166..197 CDD:293786 6/30 (20%)
ANK 4 166..195 5/28 (18%)
ANK repeat 199..231 CDD:293786 8/40 (20%)
ANK 5 199..229 8/38 (21%)
ANK 228..359 CDD:238125 26/176 (15%)
ANK 6 233..262 11/55 (20%)
Ank_4 237..286 CDD:290365 14/94 (15%)
ANK repeat 268..301 CDD:293786 4/32 (13%)
ANK 7 268..297 4/28 (14%)
Ank_2 273..368 CDD:289560 15/94 (16%)
ANK repeat 303..336 CDD:293786 3/32 (9%)
ANK 8 303..334 3/30 (10%)
ANK 333..>400 CDD:238125 11/66 (17%)
ANK repeat 338..368 CDD:293786 8/29 (28%)
ANK 9 338..367 8/28 (29%)
Ank_4 339..400 CDD:290365 10/60 (17%)
ANK 10 380..409 6/28 (21%)
TyrKc 462..718 CDD:197581 76/320 (24%)
PKc_TNNI3K 468..721 CDD:270966 76/319 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.