Protein Alignment Lrrk and MOS

DIOPT Version :9

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_005363.1
• Gene: MOS / 4342
• HGNCID: 7199
• Length: 346
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 93/390 - (23%)
• Similarity: 150/390 - (38%)
• Gaps: 106/390 - (27%)

  Fly  1755 LSVYNQSKISCPVHLE--QSMAQLAPDVIF-ADIPDKHTIPSE-----------CIIKGSLLGRG 1805
            |..|.:|:.|..|...  .|.::|...::. |.:|....:|..           |:::  .||.|
Human     7 LRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQVCLLQ--RLGAG 69

  Fly  1806 AFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTA 1870
            .||.|:||.  .||.    |||:|.:........|...:..|
Human    70 GFGSVYKAT--YRGV----PVAIKQVNKCTKNRLASRRSFWA----------------------- 105

  Fly  1871 RQELAVLLTLKHPNIVPLVGICIKPLA-------LVLELAPLGGLDALLRH---YRRSGAHMG-- 1923
              ||.| ..|:|.|||.:|....:..|       :::|   .||...|  |   |..:|...|
Human   106 --ELNV-ARLRHDNIVRVVAASTRTPAGSNSLGTIIME---FGGNVTL--HQVIYGAAGHPEGDA 162

  Fly  1924 --PHTFQTLVLQAARAIEY----------LHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHI 1976
              ||......|...:.::|          ||.:.|::.|||..|:|:.|      :|.      .
Human   163 GEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISE------QDV------C 215

  Fly  1977 KIADYGISRQ-------TAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISL 2034
            ||:|:|.|.:       ..||  ...|||....|||:::..|   .|.|.|.:||.:.:::..:.
Human   216 KISDFGCSEKLEDLLCFQTPS--YPLGGTYTHRAPELLKGEG---VTPKADIYSFAITLWQMTTK 275

  Fly  2035 RQPFEGHES--IKECILEGSRPALTQR--ETQFPTCCL-DLMVLCWHEQPRRRPTASQIVSILSA 2094
            :.|:.|...  :...:....||:|:..  |...|...| |::..||.....:||:|..::..|::
Human   276 QAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTS 340

  Fly  2095  2094
            Human   341  340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	81/331 (24%)
		STKc_LRRK	1801..2095	CDD:270902	82/330 (25%)
MOS	NP_005363.1	STKc_Mos	56..338	CDD:270881	82/337 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900