Protein Alignment Lrrk and MAP3K11

DIOPT Version :10

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_002410.1
• Gene: MAP3K11 / 4296
• HGNCID: 6850
• Length: 847
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 94/340 - (27%)
• Similarity: 151/340 - (44%)
• Gaps: 71/340 - (20%)

  Fly  1801 LLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCK 1865
            ::|.|.||.|::.:.:                          ..|:|.|.|    .:||.:....
Human   122 VIGIGGFGKVYRGSWR--------------------------GELVAVKAA----RQDPDEDISV 156

  Fly  1866 AYCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQ 1928
            ...:.|||..:...|.||||:.|..:|::.  |.||:|.|..|.|...|     :|..:.||...
Human   157 TAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-----AGRRVPPHVLV 216

  Fly  1929 TLVLQAARAIEYLHRRR---IIYRDLKSENVLVWELPQPHTEDSPRNLVH--IKIADYGISRQTA 1988
            ...:|.||.:.|||...   :|:|||||.|:|   |.||...|   ::.|  :||.|:|::|:..
Human   217 NWAVQIARGMHYLHCEALVPVIHRDLKSNNIL---LLQPIESD---DMEHKTLKITDFGLAREWH 275

  Fly  1989 PSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSR 2053
            .:......||..:||||:|:   ...:::..|.:|||:.::|.::...|:.|    .:|:.....
Human   276 KTTQMSAAGTYAWMAPEVIK---ASTFSKGSDVWSFGVLLWELLTGEVPYRG----IDCLAVAYG 333

  Fly  2054 PALTQRETQFPTCC----LDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMP----HS- 2109
            .|:.:.....|:.|    ..||..||.:.|.|||..:.|:..|.|.|...|.:   ||    ||
Human   334 VAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLRE---MPRDSFHSM 395

  Fly  2110 ----EKIVCGVFQSL 2120
                ::.:.|:|..|
Human   396 QEGWKREIQGLFDEL 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	84/304 (28%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	84/304 (28%)
		Leucine-zipper 1	403..424		3/8 (38%)
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..847