DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and MAP3K10

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens

Alignment Length:	411	Identity:	106/411 - (25%)
Similarity:	171/411 - (41%)	Gaps:	100/411 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1725 SRNTSVDGHPGY---HLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIP 1786
            |::.:|.|..|:   .||...            :.|:..:.::.......:..||..::.|
Human    47 SQDCAVSGDEGWWTGQLPSGR------------VGVFPSNYVAPGAPAAPAGLQLPQEIPF---- 95

  Fly  1787 DKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVA 1851
              |.:..|     .::|.|.||.|::|  ..||    :.||:|..:..|    .|:.|:.|.:|.
Human    96 --HELQLE-----EIIGVGGFGKVYRA--LWRG----EEVAVKAARLDP----EKDPAVTAEQVC 143

  Fly  1852 VGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRH 1914
                                ||..:...|:||||:.|.|.|:.|  |.||:|.|..|.|..:|
Human   144 --------------------QEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVL-- 186

  Fly  1915 YRRSGAHMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLKSENVLVWELPQPHTEDSPRNLVH- 1975
               :|..:.||......:|.||.:.|||...   ||:|||||.|:|:.|..:.|      ||..
Human   187 ---AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENH------NLADT 242

  Fly  1976 -IKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFE 2039
             :||.|:|::|:...:......||..:||||:||.:   .:::..|.:|||:.::|.::...|:.
Human   243 VLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS---LFSKSSDVWSFGVLLWELLTGEVPYR 304

  Fly  2040 GHESIKECILEGSRPALTQRETQFPTCCLDLMVL------------CWHEQPRRRPTASQIVSIL 2092
            ..:::  .:..|  .|:.:.....|:.|.:....            ||...|..||   ...|||
Human   305 EIDAL--AVAYG--VAMNKLTLPIPSTCPEPFARLLEGEPGPRDEECWDPDPHGRP---DFGSIL 362

  Fly  2093 SAPECIHLLDVVAMP----HS 2109
            ...|.|....:..||    ||
Human   363 KRLEVIEQSALFQMPLESFHS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	86/314 (27%)
		STKc_LRRK	1801..2095	CDD:270902	88/312 (28%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992	7/40 (18%)
		TyrKc	98..365	CDD:197581	89/322 (28%)
		PKc_like	103..368	CDD:304357	89/315 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900