DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and Takl2

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_651090.2	Gene:	Takl2 / 42692	FlyBaseID:	FBgn0039015	Length:	281	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	82/332 - (24%)
Similarity:	138/332 - (41%)	Gaps:	81/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1791 IPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKW 1855
            :|.|.|....|:|.|.:|.|::|..:.|      .:|:|.::   .|...|:
  Fly     8 VPYEEIQTKELIGTGFYGSVYRAVWRNR------EIALKRIR---EGCEDKK------------- 50

  Fly  1856 DRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGI-----CIKPLALVLELAPLGGLDALLRHY 1915
                          ..:|:..|....|.|||.|.|.     |   ..|::|....|.|.:.| |.
  Fly    51 --------------IEREIYQLTKASHVNIVELYGTSRHEGC---ALLLMEFVDGGSLSSFL-HA 97

  Fly  1916 RRSGAHMGPHTFQTLVLQAARAIEYLH---RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIK 1977
            :...::...|.| ....|.|:.|.|||   .:.:|:||:|..|.|:.|           ..:.:|
  Fly    98 KSKPSYSHAHAF-NWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCE-----------KGLKLK 150

  Fly  1978 IADYG----ISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPF 2038
            |.|:|    :|:..:.:     .||..:.|||:::.|..:   ||.|.:|:.:..:|.:|.::||
  Fly   151 ICDFGTVVDLSQSISCN-----AGTCRYKAPEVLQGNKPD---EKCDVYSWAITFWEILSRKEPF 207

  Fly  2039 EGHESIKE---CILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVS-----ILSAP 2095
            |.:.::.|   .|.||.||.|:...:..|...:.|:...|.....:| .:.:::|     |||..
  Fly   208 EQYNTLFELYMAINEGERPDLSCIMSGCPADIVALLYASWDPDISKR-FSMELISQSMGRILSEA 271

  Fly  2096 ECIHLLD 2102
            ..|..||
  Fly   272 GSIPPLD 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	74/315 (23%)
		STKc_LRRK	1801..2095	CDD:270902	76/313 (24%)
Takl2	NP_651090.2	S_TKc	14..258	CDD:214567	72/304 (24%)
Takl2	NP_651090.2	PKc_like	19..268	CDD:304357	72/309 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830