DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and cdi

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_524401.2	Gene:	cdi / 42289	FlyBaseID:	FBgn0004876	Length:	1213	Species:	Drosophila melanogaster

Alignment Length:	647	Identity:	125/647 - (19%)
Similarity:	204/647 - (31%)	Gaps:	270/647 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1676 GVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAG-----SSRNTSVDGHPG 1735
            |.|.|.|...|:|                |.:.: |.|...:.|.:||     ::..||.:|...
  Fly     8 GPGPPSEICGLSV----------------DQVDS-SAASPFIWPSTAGMCTTATTVTTSTNGDAT 55

  Fly  1736 YHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGS 1800
            ...|                 |.:|     |:|....:....|..     |...||.|:.::.||
  Fly    56 AEAP-----------------VKHQ-----PLHNGGWIGNGLPPA-----PVTRTISSDRLVTGS 93

  Fly  1801 ---------------------LLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESA 1844
                                 .:|.|.|..|:|...:..|    :.:.:||.|     .||....
  Fly    94 SCRALRTAVSALYSVDDFVKEKIGSGFFSEVYKVTHRTTG----QVMVLKMNQ-----LRANRPN 149

  Fly  1845 LMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIK--PLALVLELAPLGG 1907
            ::                         :|:.:|..|.|.||:..:|:|::  .|..:.|....|.
  Fly   150 ML-------------------------REVQLLNKLSHANILSFMGVCVQEGQLHALTEYINGGS 189

  Fly  1908 LDALLRHYRRSGAHMGPHTFQTLVLQA----------ARAIEYLHRRRIIYRDLKSENVLVWELP 1962
            |:.||.:             :.:||.|          ||.:.|:|...|.:|||.|:|||:
  Fly   190 LEQLLAN-------------KEVVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVLI---- 237

  Fly  1963 QPHTEDSPRNLVHIK----IADYGISRQTAPSGAKGFGGTEG---FMAPEIIRYNGEEEYTEKVD 2020
                    |||.:.:    :.|:|::.:......|....|.|   :::||.::   .:.|.:..|
  Fly   238 --------RNLANDQYEAVVGDFGLAAKIPVKSRKSRLETVGSPYWVSPECLK---GQWYDQTSD 291

  Fly  2021 CFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQP------ 2079
            .||||:...|.|:..:               :.|.:..|...|....|..:.||..:.|
  Fly   292 VFSFGIIQCEIIARIE---------------ADPDMMPRTASFGLDYLAFVELCPMDTPPVFLRL 341

  Fly  2080 ---------RRRPT----ASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGL 2131
                     :.|||    ..::..:|...|  |.....|.|.|.
  Fly   342 AFYCCLYDAKSRPTFHDATKKLTLLLEKYE--HESSAGASPLSS--------------------- 383

  Fly  2132 ELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCC 2196
                      :::::|||.||  ...:::.:|:..|                    |.:..:|..
  Fly   384 ----------LELINCSPGGS--DSENVTLTPRASV--------------------PTVATICTA 416

  Fly  2197 LVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLD----PNIKSAVISLVYMEKIARVAVGTHNG 2254
            ..|                |.|..||.....|    |:.|||..:|          .||.||
  Fly   417 PAG----------------TLTPRHLQEVDEDGFRFPSKKSASAAL----------PGTPNG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	70/354 (20%)
		STKc_LRRK	1801..2095	CDD:270902	69/331 (21%)
cdi	NP_524401.2	TyrKc	113..363	CDD:197581	68/326 (21%)
cdi	NP_524401.2	PKc_like	116..370	CDD:304357	69/330 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930