DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and ksr

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001287177.1	Gene:	ksr / 40660	FlyBaseID:	FBgn0015402	Length:	966	Species:	Drosophila melanogaster

Alignment Length:	1305	Identity:	243/1305 - (18%)
Similarity:	399/1305 - (30%)	Gaps:	484/1305 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   907 MTNNCLKEIPASLHELSSLSVLN-ISGNV----NITELPPHLGL-LSRLWNLNTR----GCLLQE 961
            |::|  ...|||..:..|.:..: |||::    |:..:...:.| .:.|..|.|:    ..|.|:
  Fly     1 MSSN--NNAPASAPDTGSTNANDPISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCAISSTLTQQ 63

  Fly   962 PLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKL-------------------MVVGVAGIGKS 1007
            .:| .:|||      :|.|...:.     .|:|:|                   ..:.|.|:.:.
  Fly    64 EIR-CLESK------LVRYFSELL-----LAKMRLNERIPANGLVPHTTGNELRQWLRVVGLSQG 116

  Fly  1008 TL------LDLLRQGAGSG--------SSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSAN 1058
            ||      |..|.|.....        :.|.|.|.........:.|.:.|....|....:|:|.|
  Fly   117 TLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCMESLESGTAASNN 181

  Fly  1059 --------------------ISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQY 1103
                                :..:|:.      .....:|.:|    .|.....|:....|....
  Fly   182 DPEQWHWDSWDRPTHIHRGSVGNIGLG------NNSTASPRTH----HRQHGVKGKNSALANSTN 236

  Fly  1104 FLSKRSLYLVLWRISDGHKGLAELLQWLGN-----IQARAPNSPVIIVGTHFDAVGESI------ 1157
            |.|.|          .......||....|:     :....||||.    |....:..|:
  Fly   237 FKSGR----------QSPSATEELNSTQGSQLTLTLTPSPPNSPF----TPSSGLSSSLNGTPQR 287

  Fly  1158 ---SPQKAEQLQQLIREKFIAIPDAEKIGLPRV-----IDSIEISCRTLHNIHLLANIIYDTAMQ 1214
               :|..|.:.|.|:.:..:.: |.|::...|:     .||        |: ...::|..|....
  Fly   288 SRGTPPPARKHQTLLSQSHVQV-DGEQLARNRLPTDPSPDS--------HS-STSSDIFVDPNTN 342

  Fly  1215 LRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRD 1279
            ..|.||...:|:  :|.|                 .|...|..|...|.            .|..
  Fly   343 ASSGGSSSNVLM--VPCS-----------------PGVGHVGMGHAIKH------------RFTK 376

  Fly  1280 AAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWL----CDMLAHVVTVREINPFAPTGVMKLD 1340
            |.......|.|.:.  :.|              :|:    |..:.|......:.|........:|
  Fly   377 ALGFMATCTLCQKQ--VFH--------------RWMKCTDCKYICHKSCAPHVPPSCGLPREYVD 425

  Fly  1341 DLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSR 1405
            :    ||.::.||.                                 .|:.|:.....|.|...:
  Fly   426 E----FRHIKEQGG---------------------------------YASLPHVHGAAKGSPLVK 453

  Fly  1406 GRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQI 1470
            ..:||..:.|:       :...|:||||.:|::.|.           |:.|..|       :.::
  Fly   454 KSTLGKPLHQQ-------HGDSSSPSSSCTSSTPSS-----------PALFQQR-------EREL 493

  Fly  1471 IEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTD 1535
            .:|      .|...|:.                                 :|.....:.||.:.:
  Fly   494 DQA------GSSSSANL---------------------------------LPTPSLGKHQPSQFN 519

  Fly  1536 GNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVD 1600
            .....:...|....|:|.|:..:...||......:..:|    .|::....|||.:
  Fly   520 FPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLD----SLVSSSNGHMSSL--------- 571

  Fly  1601 HIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSS 1665
                        :|::..:.|....|...||                              :.::
  Fly   572 ------------IGSQTSNASTAATLTGSLV------------------------------NSTT 594

  Fly  1666 RRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSV 1730
            .....::|...:...|.|......|.|.:.....:.....||...:..||...|....|:.
  Fly   595 TTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTE---- 655

  Fly  1731 DGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSEC 1795
            ||..|.                     :.|:.||    |::           .|||
  Fly   656 DGDSGQ---------------------WRQNSIS----LKE-----------WDIP--------- 675

  Fly  1796 IIKGSLL-----GRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKW 1855
              .|.||     |:|.||.|.:                               ||....|||...
  Fly   676 --YGDLLLLERIGQGRFGTVHR-------------------------------ALWHGDVAVKLL 707

  Fly  1856 DRDPLQ--HSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDALLRHYR 1916
            :.|.||  |..:   |.|.|:|.....:|.|:|..:|.|:.|  ||:|..|.....|...: |.|
  Fly   708 NEDYLQDEHMLE---TFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYI-HQR 768

  Fly  1917 RSGAHMGPHTFQTLVL--QAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIA 1979
            |....|.    :||::  |.|:.:.|||.|.||::||:::|:.:        |:.     .:.|.
  Fly   769 REKFAMN----RTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFI--------ENG-----KVIIT 816

  Fly  1980 DYGISRQTAPSGAK------GFGGTEG---FMAPEIIRYNGEE-------EYTEKVDCFSFGMFI 2028
            |:|:.     |..|      |.|....   ::|||:||....|       |:|...|.:|||...
  Fly   817 DFGLF-----SSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVW 876

  Fly  2029 YENISLRQPFEGH--ESIKECILEGSRPALTQ----RETQFPTCCLDLMVLCWHEQPRRRPTASQ 2087
            ||.|.....|:..  |||...:..|.:.:|..    |:.:      ||::|||..:...||..::
  Fly   877 YELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVK------DLLMLCWTYEKEHRPQFAR 935

  Fly  2088 IVSIL 2092
            ::|:|
  Fly   936 LLSLL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566	8/26 (31%)
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380	5/16 (31%)
		leucine-rich repeat	925..949	CDD:275380	5/29 (17%)
		P-loop_NTPase	993..1211	CDD:304359	47/289 (16%)
		COR	1230..1471	CDD:292713	37/244 (15%)
		STYKc	1796..2092	CDD:214568	87/328 (27%)
		STKc_LRRK	1801..2095	CDD:270902	87/325 (27%)
ksr	NP_001287177.1	KSR1-SAM	33..166	CDD:290277	26/144 (18%)
		C1_1	368..419	CDD:278556	10/78 (13%)
		PK_KSR	678..946	CDD:270965	87/326 (27%)
		Pkinase_Tyr	679..940	CDD:285015	86/323 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930