DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and pbk

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001002387.1 Gene:pbk / 360218 ZFINID:ZDB-GENE-030523-2 Length:339 Species:Danio rerio


Alignment Length:346 Identity:89/346 - (25%)
Similarity:141/346 - (40%) Gaps:94/346 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1790 TIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGK 1854
            |||:...:|  .||.|....|:..|  ..|.::..|.|:|.:     .::..:..:..::     
Zfish    32 TIPASPFMK--KLGCGTGVNVYLMN--RMGKQTHSPWAIKKI-----NSKCAQGQVSVYQ----- 82

  Fly  1855 WDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGI--------CIKPLALVLELAPLGGLDAL 1911
                      |..|   :|..:|..|||||||.....        |     |.:|......|:.|
Zfish    83 ----------KRLC---EEAKILKDLKHPNIVGFRAFTTAKDGSKC-----LAMEFGGEQSLNDL 129

  Fly  1912 LRHYRRSGAHMGP-HTFQTLVLQAARAIEYLH-RRRIIYRDLKSENVLVWELPQPHTEDSPRNLV 1974
            :...|..|....| .|.:.:.|..||.:.||| .:::::.|:||.||::           ..:..
Zfish   130 IEKRREEGLQAFPVDTIEKVALHVARGLLYLHNEKKLLHGDMKSCNVVI-----------KGDFE 183

  Fly  1975 HIKIADYGIS----RQTAPSGAKG-FGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISL 2034
            .|||.|.|:|    .....|..|. :.|||.:...|.:.   :...|:|.|.|::|:.::|.::|
Zfish   184 SIKICDVGVSLPLDENMQVSDPKAHYIGTEPWKPKEALE---DGVITDKADIFAYGLTLWEMMTL 245

  Fly  2035 RQPF------EG-----HESIKECILE-------GSRPALT--------QRETQFPTCCLDLMVL 2073
            ..|.      ||     .||.:|...|       ||||||.        ||       .::|..|
Zfish   246 SVPHLEMLDTEGDEDDDDESFEEDFDEDAYYERLGSRPALDAVTLGGSYQR-------MVELFCL 303

  Fly  2074 CWHEQPRRRPTASQIVSILSA 2094
            |..|.|::||:|:.||.:|.:
Zfish   304 CTEEDPQKRPSAAHIVQVLES 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568 85/336 (25%)
STKc_LRRK 1801..2095 CDD:270902 85/335 (25%)
pbkNP_001002387.1 PKc_TOPK 36..325 CDD:270903 86/342 (25%)
Pkinase_Tyr 38..322 CDD:285015 85/336 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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