Protein Alignment Lrrk and LIMK1

DIOPT Version :10

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 818
• Identity: 168/818 - (20%)
• Similarity: 260/818 - (31%)
• Gaps: 339/818 - (41%)

  Fly  1512 PILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDG--------------IW--------------S 1548
            |:...::.|:|   .:.|...|.||...   .||              :|              .
  Fly   168 PMHSIRLVEIP---KDATPGLRVDGVAL---DDGCPTVRITDLFCNFFLWLTSMAEQCCGAPYRI 226

  Fly  1549 DVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSL 1613
            ||||::   |.:...:.|||.:...|.:..|:...||.:    .|:|.|||:|
  Fly   227 DVNLTN---LHIGDRILEVNGTPVSDSSVEQIDKLIRSN----EKMLQLTVEH------------ 272

  Fly  1614 GTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVP--------PVGCNRPSRSSRRGAG 1670
                          ..:.:|..|. :..:|:....|...:|        .||..|..::
  Fly   273 --------------DPVQVCRSCS-QADIQRAMSASTLILPLSTSASSVEVGRERLYKT------ 316

  Fly  1671 AYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSV----- 1730
                     |||.|          ..||:.|::.::        |...|.:||::..|.:
  Fly   317 ---------PGEQG----------TKARKLRQATNA--------STTIPPAAGATAMTQLKEKER 354

  Fly  1731 -----------------DGHPGYHLPDNSNVCYAWMIEECILSVYNQSKI-SCPVHLEQSMAQLA 1777
                             ..||                     .:|:.|:. ||.|..:......|
  Fly   355 CSSLSKLLDEQHQAQQHSAHP---------------------QLYDLSRTQSCRVVQKPQRIFRA 398

  Fly  1778 PDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKE 1842
            .|::.                |..||.|.||.||    ||...:|.:.:.:|.|.      ||.|
  Fly   399 TDLVI----------------GEKLGEGFFGKVF----KVTHRQSGEVMVLKELH------RADE 437

  Fly  1843 SALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI--KPLALVLELAPL 1905
            .|...|                      .:|:|||..|.|.:::..:|:..  |.|.:|.|....
  Fly   438 EAQRNF----------------------IKEVAVLRLLDHRHVLKFIGVLYKDKKLHMVTEYVAG 480

  Fly  1906 GGLDALLRHYRRSGAHMGPHTFQT-LVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDS 1969
            |.|..|:    ...|.:.|...:. |....|..:.|||...||:|||.|.|.||.|
  Fly   481 GCLKELI----HDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNCLVRE--------- 532

  Fly  1970 PRNLVHIKIADYGISRQT----APSG---AKGFG------------------------------G 1997
            .|:::   :||:|::|..    .|||   ..|:|                              |
  Fly   533 DRSVI---VADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSKSRQRRQRYTVVG 594

  Fly  1998 TEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGH-ESIKECILEGSRPALTQRE- 2060
            ...:||||:::   ..:|.||||.||||:.:.|.|       |. |:..:.:...|..:|.|:|
  Fly   595 NPYWMAPEMMK---GLKYDEKVDVFSFGIMLCEII-------GRVEADPDFMPRNSDFSLNQQEF 649

  Fly  2061 -----TQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSL 2120
                 .|.|...:.:..:|....|..||             |...|.|               .|
  Fly   650 REKFCAQCPEPFVKVAFVCCDLNPDMRP-------------CFETLHV---------------WL 686

  Fly  2121 VGMGDD--------ERC--GLELWLPSFGSRIDILDCSPSGSLLQCNS-ISCSPQPQVAP----- 2169
            ..:.||        ||.  .:|.:...:.|..|.|..:...||...:. :..:...:::|
  Fly   687 QRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEISPVEKEK 751

  Fly  2170 ----------PKTPENGA-----------NSRARSAQR 2186
                      ||:|..|.           :.|||..||
  Fly   752 ENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQR 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	ANKYR	78..>287	CDD:440430
		ANK repeat	146..177	CDD:293786
		ANK repeat	179..209	CDD:293786
		ANK repeat	361..390	CDD:293786
		Ank_2	364..465	CDD:463710
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR	<544..>768	CDD:443914
		leucine-rich repeat	547..569	CDD:275380
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:404697
		leucine-rich repeat	855..901	CDD:275380
		LRR_4	900..941	CDD:463713
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop containing Nucleoside Triphosphate Hydrolases	993..1211	CDD:476819
		COR	1230..>1393	CDD:406489
		STKc_LRRK	1801..2095	CDD:270902	86/340 (25%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_LIMK-like	169..274	CDD:467236	27/143 (19%)
		STKc_LIMK	407..693	CDD:271056	91/371 (25%)