Protein Alignment Lrrk and Map3k7

DIOPT Version :9

• Sequence 1: NP_001262772.1
• Gene: Lrrk / 42447
• FlyBaseID: FBgn0038816
• Length: 2513
• Species: Drosophila melanogaster
• Sequence 2: NP_001101390.2
• Gene: Map3k7 / 313121
• RGDID: 1309438
• Length: 606
• Species: Rattus norvegicus
• Alignment Length: 314
• Identity: 96/314 - (30%)
• Similarity: 143/314 - (45%)
• Gaps: 79/314 - (25%)

  Fly  1801 LLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCK 1865
            ::||||||.|.||..:.      |.||:|.::        .||...||.|
  Rat    41 VVGRGAFGVVCKAKWRA------KDVAIKQIE--------SESERKAFIV--------------- 76

  Fly  1866 AYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTL 1930
                   ||..|..:.|||||.|.|.|:.|:.||:|.|..|.|..:|........:...|. .:.
  Rat    77 -------ELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA-MSW 133

  Fly  1931 VLQAARAIEYLHR---RRIIYRDLKSENVLVWELPQPHTEDSPRNLVH----IKIADYGIS--RQ 1986
            .||.::.:.|||.   :.:|:||||..|:|               ||.    :||.|:|.:  .|
  Rat   134 CLQCSQGVAYLHSMQPKALIHRDLKPPNLL---------------LVAGGTVLKICDFGTACDIQ 183

  Fly  1987 TAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFE--GHES--IKEC 2047
            |..:..|   |:..:||||:  :.| ..|:||.|.||:|:.::|.|:.|:||:  |..:  |...
  Rat   184 THMTNNK---GSAAWMAPEV--FEG-SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWA 242

  Fly  2048 ILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLL 2101
            :..|:||.|.:   ..|.....||..||.:.|.:||:..:||.|::     ||:
  Rat   243 VHNGTRPPLIK---NLPKPIESLMTRCWSKDPSQRPSMEEIVKIMT-----HLM 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	93/303 (31%)
		STKc_LRRK	1801..2095	CDD:270902	94/306 (31%)
Map3k7	NP_001101390.2	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		96/314 (31%)
		TyrKc	36..284	CDD:197581	93/303 (31%)
		STKc_TAK1	42..292	CDD:270960	96/313 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900