DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and Raf

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001096867.3 Gene:Raf / 31221 FlyBaseID:FBgn0003079 Length:739 Species:Drosophila melanogaster


Alignment Length:680 Identity:168/680 - (24%)
Similarity:255/680 - (37%) Gaps:205/680 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1581 LAEIRPHMSQVA-------------KLLALTVDHIDLLLEDWYPSLGTRFVHT-----------S 1621
            |.::.|.|.:|:             .:..|.|:.|.:.|.|.:| :.|...|.           .
  Fly   173 LRQLTPDMCEVSTTHSGRHIIPWHTDIGTLHVEEIFVRLLDKFP-IRTHIKHQIIRKTFFSLVFC 236

  Fly  1622 EG--RFLITRLVLCPRCLWKLQLQQNNE--------PSDREVPPVGCNRPSRSSRRGAGAYFLHG 1676
            ||  |.|.|.. .|.:|.::...:..|.        |.|.....:....|.            :|
  Fly   237 EGCRRLLFTGF-YCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENPD------------NG 288

  Fly  1677 VGDPGEDGALNVFSAYLNATAR-RERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPD 1740
            ||.||...|:.     .|.::| |.||...|   ||.:.|.....|:|:.|    .|.|.....|
  Fly   289 VGFPGRGTAVR-----FNMSSRSRSRRCSSS---GSSSSSKPPSSSSGNHR----QGRPPRISQD 341

  Fly  1741 ---NS--NVCYAWMIEECILSVYNQSKIS------------CPVHLEQSMAQLA-------PDVI 1781
               ||  |||.     ..|.||.::.:.|            |..|...:.|...       |...
  Fly   342 DRSNSAPNVCI-----NNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHNRPRAR 401

  Fly  1782 FADIPDKH-------------TIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQP 1833
            .||..:|:             .|.:|.|:.|..:|.|:||.|::|:.       ..|||:|.|..
  Fly   402 SADESNKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHW-------HGPVAVKTLNV 459

  Fly  1834 VPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP-LA 1897
            ..|    ..:.|.|||                      .|:|:|...:|.||:..:|...|| ||
  Fly   460 KTP----SPAQLQAFK----------------------NEVAMLKKTRHCNILLFMGCVSKPSLA 498

  Fly  1898 LVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELP 1962
            :|.:...  | .:|.:|...|......:|...:..|.|:.::|||.:.||:|||||.|:.:    
  Fly   499 IVTQWCE--G-SSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFL---- 556

  Fly  1963 QPHTEDSPRNLVHIKIADYGI-SRQTAPSGAKGFGGTEG---FMAPEIIRYNGEEEYTEKVDCFS 2023
              | ||     :.:||.|:|: :.:|..||.|......|   :||||:||......|:.:.|.::
  Fly   557 --H-ED-----LSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYA 613

  Fly  2024 FGMFIYENISLRQPFEGHESIKECIL----EG-SRPALTQRETQFPTCCLDLMVLCWHEQPRRRP 2083
            ||:.:||.::...|: ||.|.|:.||    .| .||.::|..:..|.....|...|....|:.||
  Fly   614 FGIVMYELLAECLPY-GHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRP 677

  Fly  2084 TASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCS 2148
            ....::::|.     ::|..:...|.......:.||  .:.:||    .|:|||           
  Fly   678 LFRPLLNMLE-----NMLRTLPKIHRSASEPNLTQS--QLQNDE----FLYLPS----------- 720

  Fly  2149 PSGSLLQCNSISCSPQPQVAPPKTPENGAN 2178
                                 ||||.|..|
  Fly   721 ---------------------PKTPVNFNN 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568 89/305 (29%)
STKc_LRRK 1801..2095 CDD:270902 88/303 (29%)
RafNP_001096867.3 RBD_RAF 142..212 CDD:340514 7/38 (18%)
C1_Raf 221..269 CDD:410361 9/48 (19%)
STKc_Raf 435..687 CDD:270964 87/300 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445225
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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