DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and Map3k10

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001382027.1 Gene:Map3k10 / 308463 RGDID:1308381 Length:940 Species:Rattus norvegicus


Alignment Length:406 Identity:109/406 - (26%)
Similarity:173/406 - (42%) Gaps:98/406 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1725 SRNTSVDGHPGY---HLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIP 1786
            |::.:|.|..|:   .||...            :.|:..:.::.......:..||..::.|    
  Rat    47 SQDCAVSGDEGWWTGQLPSGR------------VGVFPSNYVAPAAPAAPTDLQLPQEIPF---- 95

  Fly  1787 DKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVA 1851
              |.:..|     .::|.|.||.|::|  ..||    :.||:|..:..|                
  Rat    96 --HELQLE-----EIIGVGGFGKVYRA--LWRG----EEVAVKAARLDP---------------- 131

  Fly  1852 VGKWDRDPLQHSCKAYCTA---RQELAVLLTLKHPNIVPLVGICIKP--LALVLELAPLGGLDAL 1911
                :|||.       .||   |||..:...|:||||:.|.|.|:.|  |.||:|.|..|.|..:
  Rat   132 ----ERDPA-------VTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRV 185

  Fly  1912 LRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLKSENVLVWELPQPHTEDSPRNL 1973
            |     :|..:.||......:|.||.:.|||...   ||:|||||.|:|:.|..:.|      ||
  Rat   186 L-----AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENH------NL 239

  Fly  1974 VH--IKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQ 2036
            ..  :||.|:|::|:...:......||..:||||:||.:   .:::..|.:|||:.::|.::...
  Rat   240 ADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLS---LFSKSSDVWSFGVLLWELLTGEV 301

  Fly  2037 PFEGHESIKECILEGSRPALTQRETQFPTCCLD----LMVLCWHEQPRRRPTASQIVSILSAPEC 2097
            |:...:::  .:..|  .|:.:.....|:.|.:    |:..||...|..||   ...|||...|.
  Rat   302 PYREIDAL--AVAYG--VAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRP---DFGSILKQLEV 359

  Fly  2098 IHLLDVVAMP----HS 2109
            |....:..||    ||
  Rat   360 IEQSALFQMPLESFHS 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568 89/309 (29%)
STKc_LRRK 1801..2095 CDD:270902 91/307 (30%)
Map3k10NP_001382027.1 Leucine-zipper 1 384..405
Leucine-zipper 2 419..440
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..599
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..733
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..916
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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