DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and Ripk1

DIOPT Version :10

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001100820.1 Gene:Ripk1 / 306886 RGDID:1310158 Length:658 Species:Rattus norvegicus


Alignment Length:458 Identity:104/458 - (22%)
Similarity:164/458 - (35%) Gaps:133/458 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1776 LAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARA 1840
            :.||:..    |...:.|:.:::...|..|.||.|.....:..|.     |.:|.:...|..|..
  Rat     1 MQPDMSL----DNIKMASDDLLERKDLDSGGFGKVSLCFHRTHGF-----VILKKVYTGPNRAEY 56

  Fly  1841 KESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPL 1905
            .|:.|                          :|..::..|:|..:|.|:||.|:.          
  Rat    57 NEALL--------------------------EEGKMMHRLRHDRVVKLLGIIIEE---------- 85

  Fly  1906 GGLDALLRHYRRSGAHMGPHTFQT-----------LVLQAARAIEYLHRRRIIYRDLKSENVLVW 1959
             |..:|:..|...|..|  |..:|           ::::....:.|||...:|::|||.||:|| 
  Rat    86 -GNYSLVMEYMEQGNLM--HVLKTKESVPLSVKGRIIVEIIEGMHYLHDEGVIHKDLKPENILV- 146

  Fly  1960 ELPQPHTEDSPRNLVHIKIADYGIS---------------RQTAPSGAKGFGGTEGFMAPEIIRY 2009
                      .|:. ||||||.|::               ::.|.|..|..|||..:||||.:. 
  Rat   147 ----------DRDF-HIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLYYMAPEHLT- 199

  Fly  2010 NGEEEYTEKVDCFSFGMFIYENISLRQPFEG---HESIKECILEGSRPALTQRETQFPTCCLDLM 2071
            :...:.|||.|.:||.:.::...:.::|:|.   .|....||..|:||.:.......|...:.||
  Rat   200 DINTKPTEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSGNRPNVEDILEFCPREIISLM 264

  Fly  2072 VLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEK----IVCGVFQSLVGMGDDERCGLE 2132
            ..||...|..|||...|                     ||    .....|:..|   :::...|:
  Rat   265 ERCWQTNPEDRPTFFGI---------------------EKEFKPFYLSQFEEYV---EEDVASLK 305

  Fly  2133 LWLPS--------FGSRIDILDCSPS-------GSLLQCNSISCSPQPQVAPPKTPENGANSRAR 2182
            ...||        |..:.|.:...||       |||.....:...|..:.....:||.......|
  Rat   306 KEYPSQSPVLKRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLPMGPVEESWFSSSPEYPQEENER 370

  Fly  2183 SAQ 2185
            |.|
  Rat   371 SVQ 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430
ANK repeat 146..177 CDD:293786
ANK repeat 179..209 CDD:293786
ANK repeat 361..390 CDD:293786
Ank_2 364..465 CDD:463710
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR <544..>768 CDD:443914
leucine-rich repeat 547..569 CDD:275380
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:404697
leucine-rich repeat 855..901 CDD:275380
LRR_4 900..941 CDD:463713
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819
COR 1230..>1393 CDD:406489
STKc_LRRK 1801..2095 CDD:270902 80/322 (25%)
Ripk1NP_001100820.1 Protein Kinases, catalytic domain 23..290 CDD:473864 82/344 (24%)
Death_RIP1 570..655 CDD:260048
Blue background indicates that the domain is not in the aligned region.

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