DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and Ripk4

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001100573.1 Gene:Ripk4 / 304053 RGDID:1311691 Length:786 Species:Rattus norvegicus


Alignment Length:472 Identity:114/472 - (24%)
Similarity:171/472 - (36%) Gaps:138/472 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSDSDEARAQ-GDIGAMEVGAQKL----FSNSHPPQKQLVQPLD------------HPTPTKRQ- 47
            :|.|.|..|. ||:|..::..:||    .|.......:::||.|            |......| 
  Rat   389 LSLSFEREASTGDLGPTDIQKKKLVDAIVSGDTNKLMKILQPQDVDLVLDSSASLLHLAVEAGQE 453

  Fly    48 ----------IKTNATHSPNATFLNKCNSCRASWAPTCAVRHKTAWINDHKNVAIDFPQFNAREE 102
                      ...|.|:...:|.|:.....|........:..||: :|     |.|..|:.|   
  Rat   454 ECVKWLLLNNANPNLTNKKGSTPLHMAVERRGRGIVELLLARKTS-VN-----AKDEDQWTA--- 509

  Fly   103 VRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLDA 167
                    |..|..:|||.:.|:||     |:...||.......|.:.:|||.|.|:|.:.||..
  Rat   510 --------LHFAAQNGDEASTRLLL-----EKNASVNEVDFEGRTPMHVACQHGQENIVRTLLRR 561

  Fly   168 GADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLI 232
            |.|........:.||:.|...|||.|.:|:.......:...|::...|||.|...||.::..:||
  Rat   562 GVDVGLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILI 626

  Fly   233 SYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLG 297
            .                     |..|.|...:..||.|::|:..|:.....:||      .|..|
  Rat   627 D---------------------LSSDINICSLQAQTPLHVAAETGHTSTARLLL------HRGAG 664

  Fly   298 DSASSVSTPITPTRKRISFGIQAIMSKLHISGES-----------EGPDDLASQESTECQRCPIN 351
            ..|.:            |.|..|    ||::..:           |..|.||        |.|:|
  Rat   665 KEALT------------SEGYTA----LHLAARNGHLATVKLLIEEKADVLA--------RGPLN 705

  Fly   352 VNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEA 416
                     :|||..|...||.:||:.|         |:..:.|.:|.:      |||.:.:  |
  Rat   706 ---------QTALHLAAARGHSEVVEEL---------VSADLIDLSDEQ------GLSALHL--A 744

  Fly   417 CKQRSLAMLDLLLKHGA 433
            .:.|....:::||||||
  Rat   745 AQGRHSQTVEILLKHGA 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 30/88 (34%)
ANK 146..286 CDD:238125 36/139 (26%)
ANK repeat 146..177 CDD:293786 11/30 (37%)
Ank_4 179..232 CDD:290365 15/52 (29%)
ANK repeat 179..209 CDD:293786 8/29 (28%)
Ank_2 216..389 CDD:289560 41/183 (22%)
ANK 361..477 CDD:238125 23/73 (32%)
ANK repeat 361..390 CDD:293786 9/28 (32%)
Ank_2 364..464 CDD:289560 21/70 (30%)
ANK repeat 406..435 CDD:293786 11/28 (39%)
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359
COR 1230..1471 CDD:292713
STYKc 1796..2092 CDD:214568
STKc_LRRK 1801..2095 CDD:270902
Ripk4NP_001100573.1 STKc_RIP4_like 25..290 CDD:270927
TyrKc 26..279 CDD:197581
ANK repeat 442..470 CDD:293786 3/27 (11%)
Ank_2 444..536 CDD:289560 25/113 (22%)
ANK 471..591 CDD:238125 39/141 (28%)
ANK repeat 473..503 CDD:293786 7/35 (20%)
ANK repeat 505..536 CDD:293786 13/46 (28%)
ANK repeat 538..569 CDD:293786 11/30 (37%)
Ank_2 544..634 CDD:289560 29/110 (26%)
ANK repeat 571..602 CDD:293786 8/30 (27%)
ANK 600..725 CDD:238125 43/193 (22%)
ANK repeat 605..636 CDD:293786 11/51 (22%)
Ank_2 610..701 CDD:289560 29/141 (21%)
ANK repeat 638..669 CDD:293786 10/36 (28%)
ANK repeat 671..701 CDD:293786 8/41 (20%)
Ank_2 676..766 CDD:289560 32/120 (27%)
ANK 731..>766 CDD:238125 13/39 (33%)
ANK repeat 736..766 CDD:293786 11/34 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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