DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and Lrrk2

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_001178718.1 Gene:Lrrk2 / 300160 RGDID:1561168 Length:2526 Species:Rattus norvegicus


Alignment Length:2560 Identity:567/2560 - (22%)
Similarity:917/2560 - (35%) Gaps:919/2560 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 GHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEW 253
            |:.||.:..|.........|.....|.||.| ::..:..|::     |||       |:|.|   
  Rat   554 GNPGIQKCGLKVISSFAHLPDALEMLSLHGA-VDSVLHTLQM-----YPD-------DQEIQ--- 602

  Fly   254 RLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRI---- 314
                                 .|| ..|:|.|:..:..|..| |...:.:   :..|.:|.    
  Rat   603 ---------------------CLG-LHLMGCLMTKKNFCIGT-GHLLAKI---LASTLQRFKDVA 641

  Fly   315 ---SFGIQAIMSKLHI----------------------SGESEGPDDLASQESTECQRCPINVNL 354
               :.|:|.::|.|.:                      ||..|..|:..             :||
  Rat   642 EVQTTGLQTVLSMLDLSVSFSKLLVHYSFDVVMFHQMSSGVLEQKDEQF-------------LNL 693

  Fly   355 LCGAARETALLAAVRGGHLD---------VVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSN 410
            .|....:.|:...::...|:         :|:.||..||:.|                :..|.::
  Rat   694 CCKCFAKVAVDDELKSKMLERACDQNNSIMVECLLLLGADAN----------------QAKGATS 742

  Fly   411 VPIAEAC-KQRSLAMLDLLLKHGARD-DNGTAIGMAITCGDEAILSRLLAR-------------- 459
            : |.:.| |:.|..:::|||..|.|: |...|:.::|..||..::|.||.|              
  Rat   743 L-IYQVCEKESSPKLVELLLNSGCREQDVRKALTVSIQKGDNQVISLLLRRLALDLANNSICLGG 806

  Fly   460 ------------RVHPDSDYKINK----------------------KGLPTPVEVN--------- 481
                        .:.||....:.|                      :|:.:..|.|         
  Rat   807 FCIGKLDPSWLGPLFPDKSSNLRKQTNAGSVLARKVLRYQMRNTLQEGVASGSEGNFSEDALAKF 871

  Fly   482 ---VFLPSTSNISYSAMFPNNPTIIDWHSMGS---------SVQLSVVRV--------------- 519
               .|:|.:   |..::|..:.   |..|.||         |..:||..|               
  Rat   872 GEWTFIPDS---SMDSVFGQSD---DLDSEGSESSFLVKKKSNSVSVGEVYRDLALQRCSPNAQR 930

  Fly   520 -------------------PWMVSGVLLLNPKLQSHPRLNEVALTA------ITRIDFSHNVLTS 559
                               ..:.|...|.:.:||||.|.::.:.:.      ||.:|.|.|.|..
  Rat   931 HSSSLGPVFDHEDLLRRKRKILSSDESLRSSRLQSHTRQSDSSSSLASEREHITSLDLSANELKD 995

  Fly   560 IP---QEL---FHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPA 618
            |.   |:.   .||..|..|.:.||.:|..|..:.:|..|  |..|.|..|:..|.|:.:..:|:
  Rat   996 IDALGQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETLKC--LTHLDLHSNKFATFPSFMLKMPS 1058

  Fly   619 LSILDVSNNKL-QQLPFD-LWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPP 681
            :..||.|.|.: ..:..| :.:.|.|::.|:::|.|                             
  Rat  1059 VIHLDASRNDIGPTVVLDPVVKCPSLKQFNLSYNQL----------------------------- 1094

  Fly   682 SNKPRNVTQ--QRLTHRNLWSATLDITDNDMKWQHEQDLGDG-KTAGVGS----SQLSSLNIANN 739
            |:.|.|:.|  ::|                     ||.|.:| |.:|:.|    .:|..||::.|
  Rat  1095 SSIPENLDQVVEKL---------------------EQLLLEGNKISGICSPLSLKELKILNLSKN 1138

  Fly   740 LFTSIP--------------------AALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLS 784
            ...|:|                    ||:|.|..::|.|.:|.||...:.........|:.||:|
  Rat  1139 HIPSLPEDFLEACPKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRSLDMS 1203

  Fly   785 HNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRH 849
            ||.|...|.                                                     ..|
  Rat  1204 HNNIEHLPG-----------------------------------------------------PAH 1215

  Fly   850 LRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKE 914
            .:...||.||.:.|     |:||.|                 ::.:..|:..:..|.:::|.|||
  Rat  1216 WKSLNLRELIFSKN-----QISTLD-----------------LSENPHIWSRVEKLHLSHNKLKE 1258

  Fly   915 IPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKH---KTMD 976
            ||..:..|.:|:.|::|.|:.:...|..:|.||::|:|...|..|....       ||   |..|
  Rat  1259 IPPEIGRLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDF-------KHIGCKAKD 1316

  Fly   977 IVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLL---------DLLRQGAGSGSSSSSHRSRASE 1032
            |:.:|:...:.|.||.|||||:||..|.||:|||         :|..|||               
  Rat  1317 IIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSELGMQGA--------------- 1366

  Fly  1033 NHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW---ICEKRKRAPGSHGPVVFRTWDFGGQ 1094
                                        |||:|:..|   |..|||:      .:|...|||.|:
  Rat  1367 ----------------------------TVGIDVRDWPIQIRGKRKK------DLVLNVWDFAGR 1397

  Fly  1095 KEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISP 1159
            :|:|:||.:|:::|:|||.::.:|.|...:..:..||.||:|||.:||||:||||.|     :|.
  Rat  1398 EEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLD-----VSD 1457

  Fly  1160 QKAEQ------LQQLIREK-FIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRS 1217
            :|..:      .::|:.:: |..|.|...:......|::....:|:.|..|...|          
  Rat  1458 EKQRKACIGKITKELLNKRGFPTIRDYHFVNATEESDALAKLRKTIINESLNFKI---------- 1512

  Fly  1218 PGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRD-PVLDGEQYKRLVTE-QMRLHNYKSFRDA 1280
              ..:|::.|.||..|:.||   .:|....:|...: ||::.:...:||.| |::|       |.
  Rat  1513 --RDQPVVGQLIPDCYVELE---KIILSERKAVPTEFPVINRKHLLQLVKEHQLQL-------DE 1565

  Fly  1281 AELQQATTWCHENGVLLHYDDATLR--DYYFLDPQWLCDMLAHVVTVREINPFA-PTGVMKLDDL 1342
            .||..|..:.:|:|||||:.|..|:  |.||::|:|||.::|.::||:...... |.|::...|:
  Rat  1566 NELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLKHPKGIISRRDV 1630

  Fly  1343 Q-MLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRG 1406
            : .|.:..:...|....|. .||.||::||......||:||.|....       ..::|      
  Rat  1631 EKFLSKKKRFPKNYMAQYF-KLLEKFQIALPIGEEYLLVPSSLSDHR-------PVIEL------ 1681

  Fly  1407 RSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQII 1471
                                   |...:|...:     |:..|.|||.|||||||.|:|      
  Rat  1682 -----------------------PHCENSEIII-----RLYEMPYFPMGFWSRLINRLL------ 1712

  Fly  1472 EAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEV-PFQKTERTQPFRTD 1535
                                                            |: ||..:.|.:..|. 
  Rat  1713 ------------------------------------------------EISPFMLSGRERALRP- 1728

  Fly  1536 GNRFKLKQDGI---WSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIR-PHMSQVAKLLA 1596
             ||...:| ||   ||.         |.|     ..:..||.|:..:...:|. |...:...||.
  Rat  1729 -NRMYWRQ-GIYLNWSP---------EAY-----CLVGSEVLDSRPESFLKITVPSCRKGCILLG 1777

  Fly  1597 LTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRP 1661
            ..|||||.|:|:|:|.| .......||..|:.:        |.|....:.|...:          
  Rat  1778 RVVDHIDSLMEEWFPGL-LEIDICGEGETLLKK--------WALYSFNDGEEHQK---------- 1823

  Fly  1662 SRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSR 1726
                      ..|..:....|:|                             |..:.||      
  Rat  1824 ----------ILLDELMKKAEEG-----------------------------DLLINPD------ 1843

  Fly  1727 NTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTI 1791
                                             |.:::.|:      :|:|||:|.||:|....:
  Rat  1844 ---------------------------------QPRLTIPI------SQIAPDLILADLPRNIML 1869

  Fly  1792 PSECI----IKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAV 1852
            .::.:    ....|||.|:||.|::|      |...:.||:|:..        |.::|...    
  Rat  1870 NNDELEFEEAPEFLLGDGSFGSVYRA------AYEGEEVAVKIFN--------KHTSLRLL---- 1916

  Fly  1853 GKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRR 1917
                              ||||.||..|.||:::.|:...|:|..||:|||..|.||.||:..:.
  Rat  1917 ------------------RQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKA 1963

  Fly  1918 SGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYG 1982
            |......|   .:.|..|..:.|||...|||||||..|||::.|       .|...:..||||||
  Rat  1964 SLTRTLQH---RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-------YPNAAIIAKIADYG 2018

  Fly  1983 ISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYE--------NISLRQPFE 2039
            |::.....|.|...||.||.|||:.|  |...|.::.|.:|||:.:::        ...||.|.|
  Rat  2019 IAQYCCRMGIKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLHDIWTTGNRIMEGLRFPNE 2081

  Fly  2040 GHESIKECILEGSRPALTQRETQFPTCCLD-LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDV 2103
                ..|..::|..|...:.....|...:: |:..|..|.|:.|||::|:..||::.|.|.|:..
  Rat  2082 ----FDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRH 2142

  Fly  2104 VAMPHSEKIVCGVFQSL--------VGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSIS 2160
            :.:|....:.|....:|        :|.|:.|:           .::.:||              
  Rat  2143 IFIPKDITVECIAATNLNSKRATLWLGCGNTEK-----------GQLSLLD-------------- 2182

  Fly  2161 CSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAI----WM--GDVSGNLHAYST--S 2217
                            .|:...|.:.:....:||..||..|.    |:  |..||.|...:.  .
  Rat  2183 ----------------LNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQSGALLVINAEDE 2231

  Fly  2218 TYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTE--- 2279
            |..|....|.|.      ::.:|....|:.:..:|    ||:..|        |:|:.::.|   
  Rat  2232 TRRHTLDKMTDS------VTCLYCNSFAKQSKQSH----FLLVGT--------ADGNLMIFEDKT 2278

  Fly  2280 -ICSGF----VLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQAL----CHSEEPNLIE 2335
             .|.|.    .||     :.|....|.|           |:|:..|..:.:    |.::..:...
  Rat  2279 IKCKGAAPLKTLH-----IGDVSTPLMC-----------LSESMNSSERHITWGGCGTKIFSFSN 2327

  Fly  2336 DVKVARMCSNESH-----------------VFSCLY------PGCMVYQWDVISKRIENKLDCSK 2377
            |..:.::....::                 |.:.||      |  :|..||..::::...:||..
  Rat  2328 DFTIQKLIETRTNQLFSYSAFSDSNIIAVAVDTALYIAKKNSP--VVEVWDKKTEKLCELIDCVH 2390

  Fly  2378 LLPCSESLQSIAID-EHVNLIKCQISALAAH-NSELYIGTTWGCLIVAELHTLRPISVFRPYENE 2440
            .|  .|.:..|..| :|......::.||... |:.|:|||..|.:::.:|.|.|.|.....:.:.
  Rat  2391 FL--KEVMVKINKDSKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDS 2453

  Fly  2441 IKSIITLSKDNVP-LIATIGRRYRS 2464
            ::::.|....|:. ::..:|.:.:|
  Rat  2454 VRAMATAQLGNLKNVMLVLGYKRKS 2478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 4/10 (40%)
ANK 146..286 CDD:238125 20/96 (21%)
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365 10/42 (24%)
ANK repeat 179..209 CDD:293786 4/19 (21%)
Ank_2 216..389 CDD:289560 39/210 (19%)
ANK 361..477 CDD:238125 31/174 (18%)
ANK repeat 361..390 CDD:293786 8/37 (22%)
Ank_2 364..464 CDD:289560 26/136 (19%)
ANK repeat 406..435 CDD:293786 9/29 (31%)
ANK repeat 437..464 CDD:293786 8/52 (15%)
LRR_8 <544..580 CDD:290566 14/47 (30%)
leucine-rich repeat 547..569 CDD:275380 10/27 (37%)
LRR_8 569..629 CDD:290566 19/59 (32%)
leucine-rich repeat 570..595 CDD:275380 8/24 (33%)
leucine-rich repeat 596..618 CDD:275380 6/21 (29%)
leucine-rich repeat 619..641 CDD:275380 5/23 (22%)
leucine-rich repeat 642..676 CDD:275380 4/33 (12%)
leucine-rich repeat 677..730 CDD:275380 12/59 (20%)
LRR_8 729..788 CDD:290566 21/78 (27%)
leucine-rich repeat 731..754 CDD:275380 10/42 (24%)
LRR_8 855..933 CDD:290566 21/77 (27%)
leucine-rich repeat 855..901 CDD:275380 10/45 (22%)
leucine-rich repeat 902..924 CDD:275380 8/21 (38%)
leucine-rich repeat 925..949 CDD:275380 8/23 (35%)
P-loop_NTPase 993..1211 CDD:304359 69/236 (29%)
COR 1230..1471 CDD:292713 69/246 (28%)
STYKc 1796..2092 CDD:214568 94/308 (31%)
STKc_LRRK 1801..2095 CDD:270902 96/302 (32%)
Lrrk2NP_001178718.1 leucine-rich repeat 984..1011 CDD:275380 9/26 (35%)
leucine-rich repeat 1012..1035 CDD:275380 7/22 (32%)
leucine-rich repeat 1036..1058 CDD:275380 6/21 (29%)
leucine-rich repeat 1059..1083 CDD:275380 5/23 (22%)
leucine-rich repeat 1084..1107 CDD:275380 8/51 (16%)
leucine-rich repeat 1108..1129 CDD:275380 8/41 (20%)
leucine-rich repeat 1130..1173 CDD:275380 10/42 (24%)
leucine-rich repeat 1174..1196 CDD:275380 5/21 (24%)
leucine-rich repeat 1197..1220 CDD:275380 9/75 (12%)
leucine-rich repeat 1221..1245 CDD:275380 10/45 (22%)
Gem1 1332..1550 CDD:224025 80/286 (28%)
RocCOR 1333..1506 CDD:206741 66/226 (29%)
COR 1526..1739 CDD:292713 78/321 (24%)
S_TKc 1883..2145 CDD:214567 99/313 (32%)
STKc_LRRK2 1883..2134 CDD:270970 96/302 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 85 1.000 Domainoid score I8014
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10820at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46327
orthoMCL 1 0.900 - - OOG6_105040
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.680

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