DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and Map3k11

DIOPT Version :10

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_071295.2 Gene:Map3k11 / 26403 MGIID:1346880 Length:850 Species:Mus musculus


Alignment Length:508 Identity:122/508 - (24%)
Similarity:193/508 - (37%) Gaps:150/508 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1655 PVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLN----ATARRERRSEDSLGAGSDADS 1715
            |:|       |..|:|:....|.|....:|:....:||.|    |....|...:|.|....    
Mouse    12 PLG-------SWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRK---- 65

  Fly  1716 GVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDV 1780
              |......||:.::.|..|:           |                        ..|:...|
Mouse    66 --GDRVEVLSRDAAISGDEGW-----------W------------------------AGQVGGQV 93

  Fly  1781 -IFADIPDKHTIPSECIIKG-----------------SLLGRGAFGFVFKANCKVRGARSFKPVA 1827
             ||         ||..:.:|                 .::|.|.||.|::.:.:           
Mouse    94 GIF---------PSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWR----------- 138

  Fly  1828 MKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGIC 1892
                           ..|:|.|.|    .:||.:.......:.|||..:...|.||||:.|..:|
Mouse   139 ---------------GELVAVKAA----RQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVC 184

  Fly  1893 IKP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLK 1952
            ::.  |.||:|.|..|.|...|     :|..:.||......:|.||.:.|||...   :|:||||
Mouse   185 LEEPNLCLVMEYAAGGPLSRAL-----AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLK 244

  Fly  1953 SENVLVWELPQPHTEDSPRNLVH--IKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEY 2015
            |.|:|   |.||...|   ::.|  :||.|:|::|:...:......||..:||||:|:   ...:
Mouse   245 SNNIL---LLQPIEGD---DMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK---ASTF 300

  Fly  2016 TEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCC----LDLMVLCWH 2076
            ::..|.:|||:.::|.::...|:.|    .:|:......|:.:.....|:.|    ..||..||.
Mouse   301 SKGSDVWSFGVLLWELLTGEVPYRG----IDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 361

  Fly  2077 EQPRRRPTASQIVSILSAPECIHLLDVVAMP----HS-----EKIVCGVFQSL 2120
            :.|.|||..:.|:..|.|.|...|.:   ||    ||     ::.:.|:|..|
Mouse   362 QDPHRRPDFASILQQLEALEAQVLRE---MPRDSFHSMQEGWKREIQGLFDEL 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430
ANK repeat 146..177 CDD:293786
ANK repeat 179..209 CDD:293786
ANK repeat 361..390 CDD:293786
Ank_2 364..465 CDD:463710
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR <544..>768 CDD:443914
leucine-rich repeat 547..569 CDD:275380
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:404697
leucine-rich repeat 855..901 CDD:275380
LRR_4 900..941 CDD:463713
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819
COR 1230..>1393 CDD:406489
STKc_LRRK 1801..2095 CDD:270902 84/304 (28%)
Map3k11NP_071295.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..35 4/18 (22%)
SH3_MLK1-3 46..103 CDD:212992 16/106 (15%)
STKc_MLK3 114..380 CDD:271049 84/313 (27%)
Leucine-zipper 1 404..425 3/8 (38%)
Leucine-zipper 2 439..460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..644
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..850
Blue background indicates that the domain is not in the aligned region.

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