DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and Map3k11

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_071295.2	Gene:	Map3k11 / 26403	MGIID:	1346880	Length:	850	Species:	Mus musculus

Alignment Length:	508	Identity:	122/508 - (24%)
Similarity:	193/508 - (37%)	Gaps:	150/508 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1655 PVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLN----ATARRERRSEDSLGAGSDADS 1715
            |:|       |..|:|:....|.|....:|:....:||.|    |....|...:|.|....
Mouse    12 PLG-------SWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRK---- 65

  Fly  1716 GVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDV 1780
              |......||:.::.|..|:           |                        ..|:...|
Mouse    66 --GDRVEVLSRDAAISGDEGW-----------W------------------------AGQVGGQV 93

  Fly  1781 -IFADIPDKHTIPSECIIKG-----------------SLLGRGAFGFVFKANCKVRGARSFKPVA 1827
             ||         ||..:.:|                 .::|.|.||.|::.:.:
Mouse    94 GIF---------PSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWR----------- 138

  Fly  1828 MKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGIC 1892
                           ..|:|.|.|    .:||.:.......:.|||..:...|.||||:.|..:|
Mouse   139 ---------------GELVAVKAA----RQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVC 184

  Fly  1893 IKP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLK 1952
            ::.  |.||:|.|..|.|...|     :|..:.||......:|.||.:.|||...   :|:||||
Mouse   185 LEEPNLCLVMEYAAGGPLSRAL-----AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLK 244

  Fly  1953 SENVLVWELPQPHTEDSPRNLVH--IKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEY 2015
            |.|:|   |.||...|   ::.|  :||.|:|::|:...:......||..:||||:|:   ...:
Mouse   245 SNNIL---LLQPIEGD---DMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK---ASTF 300

  Fly  2016 TEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCC----LDLMVLCWH 2076
            ::..|.:|||:.::|.::...|:.|    .:|:......|:.:.....|:.|    ..||..||.
Mouse   301 SKGSDVWSFGVLLWELLTGEVPYRG----IDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 361

  Fly  2077 EQPRRRPTASQIVSILSAPECIHLLDVVAMP----HS-----EKIVCGVFQSL 2120
            :.|.|||..:.|:..|.|.|...|.:   ||    ||     ::.:.|:|..|
Mouse   362 QDPHRRPDFASILQQLEALEAQVLRE---MPRDSFHSMQEGWKREIQGLFDEL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	84/323 (26%)
		STKc_LRRK	1801..2095	CDD:270902	84/304 (28%)
Map3k11	NP_071295.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..35		4/18 (22%)
		SH3_MLK1-3	46..103	CDD:212992	16/106 (15%)
		STKc_MLK3	114..380	CDD:271049	84/313 (27%)
		Leucine-zipper 1	404..425		3/8 (38%)
		Leucine-zipper 2	439..460
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900