DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and DSTYK

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_056190.1 Gene:DSTYK / 25778 HGNCID:29043 Length:929 Species:Homo sapiens


Alignment Length:1132 Identity:215/1132 - (18%)
Similarity:370/1132 - (32%) Gaps:378/1132 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1078 PGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSP 1142
            ||..|.:......||..:.|....:..|.:...:....:.|..|..|:.|..  |....|.|...
Human    18 PGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTG--GGGAERGPAGD 80

  Fly  1143 VIIVGTHFDAVGE----SISPQKAEQLQQLIREKFIAIPDAEKIGLPRVI---DSIEISCRTLHN 1200
            |...|..   .|:    |..|::.:.|||::        |.    ||.::   ....:.|:.| |
Human    81 VAETGLQ---AGQLSCISFPPKEEKYLQQIV--------DC----LPCILILGQDCNVKCQLL-N 129

  Fly  1201 IHLLANIIYDTAMQLRSPGSKEPMLLQKIPASY-------IALEDIVNVIACNLRAAGRDPVLDG 1258
            :.|...::..|.:     ||:|...|:::..:|       :||.....::...:...|....:..
Human   130 LLLGVQVLPTTKL-----GSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAHQGNWETIPE 189

  Fly  1259 EQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVV 1323
            |..      :::.:|..:....|||:  .|..|   .||...|..:.....|.|  ..|:|..:|
Human   190 EDL------EVQENNEDAAHVLAELE--VTMHH---ALLQEVDVVVAPCQGLRP--TVDVLGDLV 241

  Fly  1324 TVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQE 1388
                 |.|.|.....|...::..|..| :....|.|....:..|:|                   
Human   242 -----NDFLPVITYALHKDELSERDEQ-ELQEIRKYFSFPVFFFKV------------------- 281

  Fly  1389 AATPNSGSTVKLSQRSRGRS-----------LGCSVSQEVNLNNLIYEQRSAPSSSSSSASV--- 1439
               |..||.:..|...|..|           ||...|...|.        .||...:.:.|:   
Human   282 ---PKLGSEIIDSSTRRMESERSPLYRQLIDLGYLSSSHWNC--------GAPGQDTKAQSMLVE 335

  Fly  1440 -SQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQ 1503
             |:.||.:...::           ::| ..::::|.:.:.:......|..:..:.:         
Human   336 QSEKLRHLSTFSH-----------QVL-QTRLVDAAKALNLVHCHCLDIFINQAFD--------- 379

  Fly  1504 TGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYE-- 1566
                               .|:..:..|.|.:..|.|..:                    |||  
Human   380 -------------------MQRDLQITPKRLEYTRKKENE--------------------LYESL 405

  Fly  1567 VNISQEVDDNERQLLAEIRPHMSQVAKLL--ALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITR 1629
            :||:....:..:.::.|....|.:  :||  |..::..|:::.:....:|||            .
Human   406 MNIANRKQEEMKDMIVETLNTMKE--ELLDDATNMEFKDVIVPENGEPVGTR------------E 456

  Fly  1630 LVLCPRCLWKLQLQQNNEP-SDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYL 1693
            :..|.|.:.:|.:.:.|:. :::.:..|..   .|.|..|.....|..: :..:|.::::.|.||
Human   457 IKCCIRQIQELIISRLNQAVANKLISSVDY---LRESFVGTLERCLQSL-EKSQDVSVHITSNYL 517

  Fly  1694 NATARRERRSEDSLGAGSDAD--------------SGVGP----------------DSAGSSR-- 1726
            ..........|.:..:||...              :.|.|                :|..:|:  
Human   518 KQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLA 582

  Fly  1727 -----------NTSVD-----------GHPGY--------------HLPDNSNVCYAWMIEECIL 1755
                       |:|.:           ||.|.              |.|..:.:    .:|.|.|
Human   583 KSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARL----SLESCSL 643

  Fly  1756 SVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGA 1820
            .                      ||:.      |..|.    .|..||||.:|.|:.  |...|.
Human   644 Q----------------------DVLL------HRKPK----LGQELGRGQYGVVYL--CDNWGG 674

  Fly  1821 RSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTL-KHPN 1884
            ..  |.|:|.:  |||..:              .|:...|            |...:.:| ||..
Human   675 HF--PCALKSV--VPPDEK--------------HWNDLAL------------EFHYMRSLPKHER 709

  Fly  1885 IVPLVGICI-------KPLALVLELAPL-----GGLDALLRHYRRSGAHMGPHTFQT---LVLQA 1934
            :|.|.|..|       ..:|::|.:..|     .||.|.|             |.:|   :.|..
Human   710 LVDLHGSVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGL-------------TLETRLQIALDV 761

  Fly  1935 ARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTA-PSGAKGFGGT 1998
            ...|.:||.:.:::||:|.:|||:          ..:|  ..||.|.|..:..| .||:  ..||
Human   762 VEGIRFLHSQGLVHRDIKLKNVLL----------DKQN--RAKITDLGFCKPEAMMSGS--IVGT 812

  Fly  1999 EGFMAPEIIRYNGEEEYTEKVDCFSFGMFIY----ENISLRQPFE---GHESIKECILEGSRPAL 2056
            ...||||:  :.|  :|...||.::||:..:    .::.|.:.||   ..:.:...:..|:||  
Human   813 PIHMAPEL--FTG--KYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARP-- 871

  Fly  2057 TQRETQFPTCCLDLMVLCWHEQPRRRP 2083
             :|...|...|..||..||...|.:||
Human   872 -ERLPVFDEECWQLMEACWDGDPLKRP 897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560
ANK 146..286 CDD:238125
ANK repeat 146..177 CDD:293786
Ank_4 179..232 CDD:290365
ANK repeat 179..209 CDD:293786
Ank_2 216..389 CDD:289560
ANK 361..477 CDD:238125
ANK repeat 361..390 CDD:293786
Ank_2 364..464 CDD:289560
ANK repeat 406..435 CDD:293786
ANK repeat 437..464 CDD:293786
LRR_8 <544..580 CDD:290566
leucine-rich repeat 547..569 CDD:275380
LRR_8 569..629 CDD:290566
leucine-rich repeat 570..595 CDD:275380
leucine-rich repeat 596..618 CDD:275380
leucine-rich repeat 619..641 CDD:275380
leucine-rich repeat 642..676 CDD:275380
leucine-rich repeat 677..730 CDD:275380
LRR_8 729..788 CDD:290566
leucine-rich repeat 731..754 CDD:275380
LRR_8 855..933 CDD:290566
leucine-rich repeat 855..901 CDD:275380
leucine-rich repeat 902..924 CDD:275380
leucine-rich repeat 925..949 CDD:275380
P-loop_NTPase 993..1211 CDD:304359 29/139 (21%)
COR 1230..1471 CDD:292713 46/262 (18%)
STYKc 1796..2092 CDD:214568 80/312 (26%)
STKc_LRRK 1801..2095 CDD:270902 79/307 (26%)
DSTYKNP_056190.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 2/2 (100%)
PKc_Dusty 651..912 CDD:270877 81/317 (26%)
S_TKc 653..897 CDD:214567 78/313 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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