DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and Ripk3

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_647558.2	Gene:	Ripk3 / 246240	RGDID:	628899	Length:	478	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	114/546 - (20%)
Similarity:	198/546 - (36%)	Gaps:	191/546 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1791 IPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKW 1855
            :.||.:.....:|:|.||.||                           ||:.:|          |
  Rat    17 VGSEELENLGFVGKGGFGAVF---------------------------RARHTA----------W 44

  Fly  1856 DRD---PLQHSCKAYCTARQELAVLLTLKHPNIVPLVGIC-------IKPLALVLELAPLGGLDA 1910
            :.|   .:.:|.|    ..:|:..::.|:|.|::.|:|:.       :...|||......|.|..
  Rat    45 NLDVAVKIVNSKK----ISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSG 105

  Fly  1911 LLRHYRRSGAHMGPHTFQTLVLQAARAIE-------YLH--RRRIIYRDLKSENVLVWELPQPHT 1966
            ||:       ...|..:..|    .|.:|       |||  ...:::||||..|||:
  Rat   106 LLQ-------PSCPRPWPLL----CRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLL-------- 151

  Fly  1967 EDSPRNLVHIKIADYGI------SRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFG 2025
              .|.  :|.|:||:|:      |:..:.||::..|||..::|||::..:|:.  ::..|.:|||
  Rat   152 --DPE--LHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKA--SKASDVYSFG 210

  Fly  2026 MFIYENISLRQPFEGHESIKECILEGS------RPALTQRETQFPTC-----CLDLMVLCWHEQP 2079
            :.::..::.|   |.....|..::.|:      ||.||:.....|..     ..:||..||..:|
  Rat   211 VLVWTVLAGR---EAEVVDKTSLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEP 272

  Fly  2080 RRRPT--------------------------------------------ASQIVSILSAPECIHL 2100
            :.||:                                            :||..:.:..|....:
  Rat   273 KDRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSARESSQKGTEVDCPRETIV 337

  Fly  2101 LDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQP 2165
            .:::...|.|:....|.:.|..:  .||.|.|   .|||      ..:|:|:    :|.:.:..|
  Rat   338 YEMLDRLHLEEPSGSVPERLTSL--TERRGKE---ASFG------HATPAGT----SSDTLAGTP 387

  Fly  2166 QVAPPKTPENGANSRARSAQRL---PKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYML 2227
            |: |...|..|...|....:..   |:.|            .||...:...|:.:.
  Rat   388 QI-PHTLPSRGTTPRPAFTETPGPDPQRN------------QGDGRNSNPWYTWNA--------- 430

  Fly  2228 DPNIKSAVISLVYMEKIARVAVGTHN 2253
             ||..:.:.|:| :...:.|.:|.||
  Rat   431 -PNPMTGLQSIV-LNNCSEVQIGQHN 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	78/375 (21%)
		STKc_LRRK	1801..2095	CDD:270902	78/373 (21%)
Ripk3	NP_647558.2	PKc_like	28..285	CDD:419665	76/325 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..429		21/92 (23%)
		RHIM	408..458	CDD:403811	13/70 (19%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250\|UniProtKB:Q9Y572	437..461		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900