DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and Mos

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_064487.3	Gene:	Mos / 24559	RGDID:	3103	Length:	342	Species:	Rattus norvegicus

Alignment Length:	327	Identity:	74/327 - (22%)
Similarity:	120/327 - (36%)	Gaps:	92/327 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866
            ||.|.||.|:||.  ..|.    |||:|.:.......||.:.:..|
  Rat    68 LGSGGFGSVYKAT--YHGV----PVAIKQVNKCTRNLRASQRSFWA------------------- 107

  Fly  1867 YCTARQELAVLLTLKHPNIVPLVGICIKPL-------ALVLELAPLGGLDALLRHYRRSGAHMGP 1924
                  ||.: ..|.|.|||.:|....:..       .:::|   .||...|  |....||...|
  Rat   108 ------ELNI-ARLHHDNIVRVVAASTRTPEGSNSLGTIIME---FGGNVTL--HQVIYGATRSP 160

  Fly  1925 HTFQ-----------TLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKI 1978
            ....           ...|.....:.:||.:.|::.|||..|:|:          |.:::  .||
  Rat   161 EPLSCREQLSLGKCLKYSLDIVNGLLFLHSQSILHLDLKPANILI----------SEKDV--CKI 213

  Fly  1979 ADYGISR-----QTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPF 2038
            :|:|.|:     :...:.....|||....|||:::   .|..|.|.|.:|||:.:::..:...|:
  Rat   214 SDFGCSQKLQDLRCRQASLHHIGGTYTHQAPELLK---GEIATPKADIYSFGITLWQMTTREVPY 275

  Fly  2039 EGHESIKE--CILEGSRP---------ALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSIL 2092
            .|.....:  .:....||         :||.:..|      :::..||..:..:||.|..:...|
  Rat   276 SGEPQYVQYAVVAYNLRPSLAGAVFTASLTGKTLQ------NIVQSCWEARALQRPGAELLQKDL 334

  Fly  2093 SA 2094
            .|
  Rat   335 KA 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	72/323 (22%)
		STKc_LRRK	1801..2095	CDD:270902	74/327 (23%)
Mos	NP_064487.3	STKc_Mos	58..329	CDD:270881	72/318 (23%)
Mos	NP_064487.3	S_TKc	64..331	CDD:214567	72/320 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900