DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and Ankk1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001363880.1	Gene:	Ankk1 / 244859	MGIID:	3045301	Length:	746	Species:	Mus musculus

Alignment Length:	669	Identity:	134/669 - (20%)
Similarity:	237/669 - (35%)	Gaps:	229/669 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1827 AMKMLQPVPPGARAKE-SALMAF------------------KVAVGKWDRDPLQHSCK-AYC--- 1868
            |.::|.|:..|..|:: .:|..|                  ||...:..|...|::.| :.|
Mouse     6 ARRLLNPMAVGPLAQQLGSLTVFTRDDFEEEWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQK 70

  Fly  1869 -TARQELAVLL-------TLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPH 1925
             |...|:..|.       .:|..:||.:.|:|.:||.:|:|....|.|:..|          ..|
Mouse    71 ETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVCKQPLGIVMEFMASGSLEKTL----------PTH 125

  Fly  1926 TF-----QTLVLQAARAIEYLH--RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGI 1983
            :.     ..::.:.:.|:.:||  :..:::.|||..|:|:            .|.:|:||:|:|:
Mouse   126 SLCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILL------------DNNMHVKISDFGL 178

  Fly  1984 SRQTAPSGAKGF------GGTEGFMAPEIIRYNGE---EEYTEKVDCFSFGMFIYENISLRQPFE 2039
            |:....|..|.:      .||..::.||:...|.:   .||    |.:||.:.|:|.::.::|:.
Mouse   179 SKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEY----DVYSFAIVIWEILTQKKPYA 239

  Fly  2040 GHE--SIKECILEGSRPALTQRETQFPT---CCLDLMVLCWHEQPRRRPTASQIVSILSAPECIH 2099
            |..  :|...:..|.||:|.....::|.   ..::||..||.:.|::||....:     |.|...
Mouse   240 GLNMMTIIIRVAAGMRPSLQDVSDEWPEEVHQMVNLMKRCWDQDPKKRPCFLNV-----AVETDM 299

  Fly  2100 LLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQ 2164
            ||.:...|.::                         |...:....:.|.|  ||.|.:.:|....
Mouse   300 LLSLFQSPMTD-------------------------PGCEALTQKVSCKP--SLSQPHKVSKEVN 337

  Fly  2165 PQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDP 2229
            .::|          ..|.|:..|.              |:..:|.:
Mouse   338 QEIA----------DSAVSSDSLK--------------WILQLSDS------------------- 359

  Fly  2230 NIKSAVISLVYMEKIAR---VAVGTHNGRVFLVDATQMPSNCAFAEGSFVL--------TEICSG 2283
              ||.|.|.||..::..   :..|....:|.|:.:..:..:|..|.|...|        .::|:.
Mouse   360 --KSLVASDVYENRVTPLHFLVAGGSLEQVRLLLSHDVDVDCQTASGYTPLLIATQDQQPDLCAL 422

  Fly  2284 FVLHAACSVVVDGIYELWCGEIAGKINVFPLN---ENG-------VSGHQALCHSEE-------- 2330
            .:.|.|.:.:.|  .:.|.          ||:   :||       :..|.||.::.|
Mouse   423 LLAHGADTNLAD--EDGWA----------PLHFAAQNGDDHTARLLLDHGALVNAREHEGWTPLH 475

  Fly  2331 ---PNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDE 2392
               .|..|:  |||:..:.              |.|:.....|.|          ..|...|...
Mouse   476 LAAQNNFEN--VARLLVSR--------------QADLSPHEAEGK----------TPLHVAAYFG 514

  Fly  2393 HVNLIKCQISALAAHNSEL 2411
            |:.|:|    .|:...:||
Mouse   515 HIGLVK----LLSGQGAEL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	73/316 (23%)
		STKc_LRRK	1801..2095	CDD:270902	73/319 (23%)
Ankk1	NP_001363880.1	PKc_like	37..305	CDD:389743	70/298 (23%)
		PHA02876	<364..>694	CDD:165207	40/208 (19%)
		ANK 1	370..399		3/28 (11%)
		ANK repeat	373..401	CDD:293786	4/27 (15%)
		ANK repeat	403..434	CDD:293786	5/30 (17%)
		ANK 2	403..432		5/28 (18%)
		ANK repeat	436..467	CDD:293786	8/40 (20%)
		ANK 3	436..465		8/38 (21%)
		ANK 4	469..498		7/44 (16%)
		ANK repeat	469..497	CDD:293786	7/43 (16%)
		ANK repeat	502..532	CDD:293786	10/42 (24%)
		ANK 5	502..531		10/42 (24%)
		ANK 6	535..564
		ANK repeat	537..566	CDD:293786
		ANK repeat	568..599	CDD:293786
		ANK 7	568..597
		ANK 8	601..630
		ANK repeat	602..632	CDD:293786
		ANK repeat	634..665	CDD:293786
		ANK 9	634..663
		ANK repeat	667..698	CDD:293786
		ANK 10	667..696
		Ank_2	672..>742	CDD:372319
		ANK repeat	700..730	CDD:293786
		ANK 11	700..729
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900