DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and Lrrk1

DIOPT Version :10

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:XP_006540901.1 Gene:Lrrk1 / 233328 MGIID:2142227 Length:2015 Species:Mus musculus


Alignment Length:2287 Identity:539/2287 - (23%)
Similarity:873/2287 - (38%) Gaps:653/2287 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   329 GESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPV 393
            |:.|....|.:::..|....|.:.|        .|::|| ..||.:||:.||:....|       
Mouse    99 GDLETVQFLLTEKRVELPTEPTDDN--------PAVVAA-HFGHAEVVRELLESLPGP------- 147

  Fly   394 EDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLL-LKHGARDDNGTA------------IGMAI 445
                   |..:  .|.|..:|.||::..|.::.|| |.|||..:|...            :..||
Mouse   148 -------CTPQ--RLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAI 203

  Fly   446 TCGDEAILSRLLARRVH---------PDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPT 501
            ..|:|.|...||....:         |:....:.:|..   :|.:. |||:        :|....
Mouse   204 KAGNEDIAIFLLRHGAYFCSYILLDSPEPSKHLLRKYF---IEASA-LPSS--------YPGKIA 256

  Fly   502 I-IDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQEL- 564
            : :.|         |.:::|| |....||:...|            ||.:|.|.|.|.|:|..: 
Mouse   257 LRVKW---------SHLKLPW-VDLDWLLDISCQ------------ITELDLSANCLPSLPSIIP 299

  Fly   565 FHLVSLRYLNVAQNKITDLP-APIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNK 628
            :.|::|:.||::.|::.:|| ........|..|.|:.:..|:|:.||....||..|..|..|.|.
Mouse   300 WGLINLKKLNLSNNQLGELPCVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNY 364

  Fly   629 LQQLPFDLWRAP------KLRELNVAFNLLRDLPVPPMQTSSSLLSLD--KLNLQSFEEPPSNKP 685
            |::| |:...|.      ||:||::|.|.|.:|||..|.:..||.||:  :.||:||.:|     
Mouse   365 LERL-FEEENATNWIGLRKLQELDLADNRLTELPVQFMHSFKSLTSLNVSRNNLKSFPDP----- 423

  Fly   686 RNVTQQRLTHRNLWSATL---DITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAA 747
                         ||..|   ..:.|.:     :.|.| |.|....|.|...:.:.|....:|..
Mouse   424 -------------WSCPLKCCKASKNAL-----ESLPD-KMAVFWKSHLRDADFSENSLKEVPLG 469

  Fly   748 LPCLAVNLTRLNMSYNSLRSMGHVTSYPAT-LKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQ 811
            |..|.. |..|.:..|.|.|:.....:..| ||.||||.|::                       
Mouse   470 LFQLDA-LMFLRLQGNQLLSLPPQEKWTCTQLKTLDLSRNQL----------------------- 510

  Fly   812 LPEGRDDD-YKTA-----SSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQL 870
               |:::| .||.     :::|...|.|. .||:|:                             
Mouse   511 ---GKNEDGLKTKRISLFTTRGRQRSGTE-TASMLE----------------------------- 542

  Fly   871 STDDATTLFNESEDADWSVVGVNRSKVIFP-----NLSMLDMTNNCLKEIPASLHELSSLSVLNI 930
                                        ||     :|.:|.:.:|.|..:|.|:..|.:||.|.:
Mouse   543 ----------------------------FPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYL 579

  Fly   931 SGNVNITELPPHLGLLSRLWNLNTRGCLLQE-PLRSMIESKKHKTMDIVGYLKSIYEDAQPYARM 994
            ..|..:.||||.||.|..||.|:.....:.. |    .|.:|......:.:|::....|:....|
Mouse   580 GNNPGLRELPPELGQLGNLWQLDIEDLNISNVP----AEVRKEGPKATLSFLRAQLRKAEKCKLM 640

  Fly   995 KLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANI 1059
            |:::||....||||||::|:.|.                  |.::.|:.:|.|:.:         
Mouse   641 KMILVGPPRQGKSTLLEILQTGK------------------APQLAHSEATIRTTK--------- 678

  Fly  1060 STVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGL 1124
                     |..::...:......|.|..||.||.......:|.|.:.::||:|:|.::.|.:.:
Mouse   679 ---------WELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAV 734

  Fly  1125 AELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVI- 1188
            |.|..||.||:|:|||:.|::||||.|.:......::...|:..:.....:...:...|.|.:. 
Mouse   735 ANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITF 799

  Fly  1189 -DSIEISCRTLHNIHLLANIIYDTAMQLRSPGSK---EPMLLQKIPASYIALEDIVNVIACNLRA 1249
             ...||||:.|.....|..:|:.....::..||.   :.:..:.||.|||:|::.  |:|...|.
Mouse   800 KHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEA--VLAEQQRR 862

  Fly  1250 AGRDPV--LDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDAT--LRDYYFL 1310
            :..|.|  |...|..:|| ||...::.|.:.|   ||.|.::..|.|.|||:.|.:  ||:.|||
Mouse   863 SLGDQVQYLTDRQLDQLV-EQTPGNDIKDYED---LQSAISFLIETGTLLHFPDTSHGLRNLYFL 923

  Fly  1311 DPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDS 1375
            ||.||.:.|..:..::.....|..||::.:||:||.............|. ..|.|||:||...:
Mouse   924 DPIWLSECLQRIFNIKGSRSVAKNGVIQAEDLRMLLVGTGFTQQTEEQYF-QFLAKFEIALPVAN 987

  Fly  1376 RTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVS 1440
            .:.|:|.||||:...                                        .:.|....::
Mouse   988 DSYLLPHLLPSKPGL----------------------------------------DTHSMRHPMA 1012

  Fly  1441 QGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTG 1505
            ..::|:..|::.|.|||.|.|.|:|           :.:|..|...|:.:.:.:...:       
Mouse  1013 NTIQRVFKMSFVPVGFWQRFIARML-----------ISLAEMDLQLFENKKNTKSRNR------- 1059

  Fly  1506 LALYYGPILIFKIWEVPFQKTERTQ--PFRTDGNRFKLKQDGIW------------SDVN--LSS 1554
                       |:....|..::|.:  .||...|:....|:|:.            ||||  ...
Mouse  1060 -----------KVTIYSFTGSQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKK 1113

  Fly  1555 SSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVH 1619
            |..:::        |.|          :|:|...:     :|...||::.|::.|:|:|...   
Mouse  1114 SGGIKI--------ICQ----------SEMRDFSA-----MAFITDHVNSLIDQWFPALTAT--- 1152

  Fly  1620 TSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDG 1684
            .|:|..|:.:.|.||.|  :....|:.:|::|                                 
Mouse  1153 ESDGTPLMEQYVPCPVC--EASWAQHADPNER--------------------------------- 1182

  Fly  1685 ALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWM 1749
                                                                    :.:|.| :.
Mouse  1183 --------------------------------------------------------SESVQY-FD 1190

  Fly  1750 IEECILSVYNQSKISCPVH--LEQSMAQLAPDVIFADIPDK---------HTIPSECIIKGSLLG 1803
            :|:|:|:...:..||||.|  |...:.:|.|::...|.|.:         ||..     :.|:||
Mouse  1191 MEDCVLTAIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEG-----ENSILG 1250

  Fly  1804 RGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQH-----S 1863
            :|..|.|. ...:.:|    :|||:|...            :..||.:........|:|     :
Mouse  1251 QGGSGTVI-YQARYQG----QPVAVKRFH------------IKKFKNSANAPADTMLRHLRAMDA 1298

  Fly  1864 CKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHM--GPHT 1926
            .|.:...|||.::|..|:||.||.|:||.|.||...|||||||.|:.:|....:..:.|  |...
Mouse  1299 MKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHML 1363

  Fly  1927 FQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSG 1991
            .|.:..|.|..:.|||::.||:.||||:|:|||.|       |.:..::||::|||||||:...|
Mouse  1364 TQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSL-------SAKEHINIKLSDYGISRQSFHEG 1421

  Fly  1992 AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIK--ECILEGSRP 2054
            |.|..||.|:.||||   .....|.||||.||:||.:||.:|.::|..||..::  :.:.:|.||
Mouse  1422 ALGVEGTPGYQAPEI---RPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRP 1483

  Fly  2055 ALTQ-RETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQ 2118
            .|.| .|.||.. ...||:.||..:|.:||.|..:||.:..|.....:.:        :.||. |
Mouse  1484 VLGQPEEVQFHR-LQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYM--------LPCGK-Q 1538

  Fly  2119 SLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARS 2183
            |.......:...:..|.....||...:..:..| ||:...::|                      
Mouse  1539 SAFFSSQSQEYTVVFWDGKEESRNYTVVNTEKG-LLEVQRMTC---------------------- 1580

  Fly  2184 AQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLF--SYMLD-PNIKSAVISLVYMEKIA 2245
                |.|.:.|...|..::|:......::.||......|.  ...|| |.:.:..:::..::|.:
Mouse  1581 ----PGMKLSCQLKVQSSVWIATEDQKIYIYSLKGMCPLSVPQQALDTPAVVTCFLAVPVIKKNS 1641

  Fly  2246 -RVAVGTHNG--RVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAA-----CSVVVDGIYELWC 2302
             .|..|..:|  .||.|.......:|::         :||    |.|     |....|       
Mouse  1642 FLVLAGLADGLVAVFPVARGTPKESCSY---------LCS----HTANRSKFCIPDED------- 1686

  Fly  2303 GEIAGKINVFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDV--I 2365
                .:.|.:|                       ||...:.::.|.|:....||.:|....:  |
Mouse  1687 ----ARQNPYP-----------------------VKAMEVVNSGSEVWYSNGPGLLVIDCTILDI 1724

  Fly  2366 SKRIE--------NKLDCSKLLPCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIV 2422
            |:|:|        ..|.||.  .|........:|:..|.:      :..|::...:...:.|   
Mouse  1725 SRRLEPYAAPSMVTSLVCSS--DCRGEEMVWCLDDKANCL------VMYHSATYQLCARYFC--- 1778

  Fly  2423 AELHTLRPISVFRPYENEIK-SIITLSKDNV-PLIATIGRRYRSLISRYVDSAESS-----TKSS 2480
            .:.:.||.....:|...|.. |..|.||..| ..||.:...|...:...:.:.:.|     :.||
Mouse  1779 GDPNPLRDTFSVQPSVLETPGSHKTTSKGPVEECIADVSIMYSEELGTQILTHQDSLTDYCSMSS 1843

  Fly  2481 AVSTPTHGAAKS 2492
            ..|:|.|...:|
Mouse  1844 YSSSPPHQDPRS 1855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430
ANK repeat 146..177 CDD:293786
ANK repeat 179..209 CDD:293786
ANK repeat 361..390 CDD:293786 10/28 (36%)
Ank_2 364..465 CDD:463710 31/122 (25%)
ANK repeat 406..435 CDD:293786 12/29 (41%)
ANK repeat 437..464 CDD:293786 8/47 (17%)
LRR <544..>768 CDD:443914 70/236 (30%)
leucine-rich repeat 547..569 CDD:275380 9/22 (41%)
leucine-rich repeat 570..595 CDD:275380 7/25 (28%)
leucine-rich repeat 596..618 CDD:275380 8/21 (38%)
leucine-rich repeat 619..641 CDD:275380 8/27 (30%)
leucine-rich repeat 642..676 CDD:275380 16/35 (46%)
leucine-rich repeat 677..730 CDD:275380 10/55 (18%)
leucine-rich repeat 731..754 CDD:275380 5/22 (23%)
LRR_8 855..933 CDD:404697 12/82 (15%)
leucine-rich repeat 855..901 CDD:275380 2/50 (4%)
LRR_4 900..941 CDD:463713 14/45 (31%)
leucine-rich repeat 902..924 CDD:275380 7/21 (33%)
leucine-rich repeat 925..949 CDD:275380 11/23 (48%)
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819 56/219 (26%)
COR 1230..>1393 CDD:406489 57/166 (34%)
STKc_LRRK 1801..2095 CDD:270902 111/303 (37%)
Lrrk1XP_006540901.1 ANKYR 59..>219 CDD:440430 37/144 (26%)
ANK repeat 92..120 CDD:293786 4/20 (20%)
ANK repeat 149..187 CDD:293786 13/39 (33%)
ANK repeat 189..219 CDD:293786 7/29 (24%)
LRR <265..>518 CDD:443914 87/317 (27%)
leucine-rich repeat 282..304 CDD:275380 8/21 (38%)
leucine-rich repeat 305..331 CDD:275380 7/25 (28%)
leucine-rich repeat 332..382 CDD:275380 16/50 (32%)
leucine-rich repeat 355..378 CDD:275380 8/23 (35%)
leucine-rich repeat 383..406 CDD:275380 10/22 (45%)
leucine-rich repeat 407..452 CDD:275380 16/68 (24%)
leucine-rich repeat 453..475 CDD:275380 5/21 (24%)
LRR <469..>617 CDD:443914 50/236 (21%)
leucine-rich repeat 476..499 CDD:275380 5/22 (23%)
leucine-rich repeat 500..550 CDD:275380 19/133 (14%)
leucine-rich repeat 551..573 CDD:275380 7/21 (33%)
P-loop containing Nucleoside Triphosphate Hydrolases 640..822 CDD:476819 56/217 (26%)
COR 845..1037 CDD:406489 67/238 (28%)
STKc_LRRK1 1249..1524 CDD:270969 111/302 (37%)
Blue background indicates that the domain is not in the aligned region.

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