DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrrk and Ripk1

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_001346926.1	Gene:	Ripk1 / 19766	MGIID:	108212	Length:	656	Species:	Mus musculus

Alignment Length:	456	Identity:	106/456 - (23%)
Similarity:	170/456 - (37%)	Gaps:	128/456 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1776 LAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARA 1840
            :.||:..    |...:.|..:::.:.|..|.||.|  :.|.   .||...|.:|.:...|..|..
Mouse     1 MQPDMSL----DNIKMASSDLLEKTDLDSGGFGKV--SLCY---HRSHGFVILKKVYTGPNRAEY 56

  Fly  1841 KESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPL 1905
            .|..|                          :|..::..|:|..:|.|:||.|:.
Mouse    57 NEVLL--------------------------EEGKMMHRLRHSRVVKLLGIIIEE---------- 85

  Fly  1906 GGLDALLRHYRRSGAHMGPHTFQT-----------LVLQAARAIEYLHRRRIIYRDLKSENVLVW 1959
             |..:|:..|...|..|  |..:|           ::::|...:.|||.:.:|::|||.||:||
Mouse    86 -GNYSLVMEYMEKGNLM--HVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILV- 146

  Fly  1960 ELPQPHTEDSPRNLVHIKIADYGIS----------------RQTAPSGAKGFGGTEGFMAPEIIR 2008
                      .|:. ||||||.|::                ::.:.:..|..|||..:||||.:.
Mouse   147 ----------DRDF-HIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLN 200

  Fly  2009 -YNGEEEYTEKVDCFSFGMFIYENISLRQPFEG---HESIKECILEGSRPALTQRETQFPTCCLD 2069
             .|.:.  |||.|.:|||:.::...:.::|:|.   .|....||..|:||.:.:.....|...:.
Mouse   201 DINAKP--TEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIIS 263

  Fly  2070 LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELW 2134
            ||..||...|..|||      .|...|...   ...:.|.|:.|           :::...|:..
Mouse   264 LMERCWQAIPEDRPT------FLGIEEEFR---PFYLSHFEEYV-----------EEDVASLKKE 308

  Fly  2135 LPS--------FGSRIDILDCSPS-------GSLLQCNSISCSPQPQVAPPKTPENGANSRARSA 2184
            .|.        |..:.|.:...||       |||.....:...|..:.....:||...:...||.
Mouse   309 YPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSV 373

  Fly  2185 Q 2185
            |
Mouse   374 Q 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	82/326 (25%)
		STKc_LRRK	1801..2095	CDD:270902	83/324 (26%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	84/334 (25%)
		Interaction with SQSTM1. /evidence=ECO:0000250\|UniProtKB:Q13546	291..567		18/95 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..373		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983, ECO:0000269\|PubMed:27819681, ECO:0000269\|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900