DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and lrk-1

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_492839.4 Gene:lrk-1 / 172995 WormBaseID:WBGene00003068 Length:2393 Species:Caenorhabditis elegans


Alignment Length:2596 Identity:817/2596 - (31%)
Similarity:1248/2596 - (48%) Gaps:488/2596 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 CAVRHKTAWINDHKNVA---IDFPQFNAREEVRQIKHGELRTAVISGDERTVRVL---LAALGTE 133
            ||:  :.|.:..|..||   ||..| ...|::.: .|..:.:|.|||....|..:   .......
 Worm   126 CAL--ELAQMAGHNEVAAKLIDAIQ-KESEDLNE-AHTMIISACISGSADVVYEISRRFMEKKQS 186

  Fly   134 RQIIVNMAPSGANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLML 198
            |:|:.|.......|.|.:||.:|:..|.:.||..........|:|.:.::|||.|.::.:.:|.|
 Worm   187 REILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCL 251

  Fly   199 DHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYP-DYLYQTYRDEEGQWEWRLPFDANAH 262
            :.||:|::....|....||.|...|..:.:..::::.:| :::.:.  |..|...::|..|.|..
 Worm   252 EKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEI--DTVGAPAYQLALDVNEV 314

  Fly   263 DVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHI 327
            |...:|::|:|...|:.::|..:..::  |                                ..|
 Worm   315 DGECRTAMYLAVAEGHLEVVKAMTDFK--C--------------------------------TSI 345

  Fly   328 SGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKP 392
            .|.               ||||..:::.|...|...:|||. ..:|.::..||..||:.|:   |
 Worm   346 DGR---------------QRCPFQLDVYCTRGRTPFMLAAF-NQNLPLMTLLLDAGADVNL---P 391

  Fly   393 VEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEAILSRLL 457
            :...:.....||...:.:..:.||.:...|.::..||..||.|.:..|:.:|....:|.::...|
 Worm   392 LAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFL 456

  Fly   458 ARRVHPDSDYKINKKGLPT-PVEV-NVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVP 520
            .|.|..|.:||||||.:.. .::| ...||       |::.|:....::|    :|..|..::..
 Worm   457 VRLVFADPEYKINKKNIDVGQIQVGQSLLP-------SSLCPSKAAQLNW----NSANLEQLQSD 510

  Fly   521 WMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITDLPA 585
            |.|:..|.:||:|    |...::|.||||:|.|.|.|.:.|..||.:.|||.||:|.|.|..:..
 Worm   511 WFVAAALHVNPRL----RTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEI 571

  Fly   586 PIGQTY--GCPVLDELFLQDNQLTTLPAA-IFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNV 647
            |   ||  ....|:.|.|::|||..:... :..||.|..||||.|:|.|||..:|..|.|:|||.
 Worm   572 P---TYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNA 633

  Fly   648 AFNLLRDLPV---------PPMQTSSSLLSLDKLNLQS---------FEEPPSNKPRNVTQQRLT 694
            ::|.|..||:         |.:..|:     :..|.||         .::||     |||...|.
 Worm   634 SYNRLSTLPMVARASRGERPRLNNSN-----NNFNTQSPTQESNPIVVDDPP-----NVTSNPLR 688

  Fly   695 HRNLWSATLDIT--DNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTR 757
            .:|:|.|:::::  |:|..:.        ......|:.|:::|::.|.|.:.|..|.|....|..
 Worm   689 RQNVWQASINLSKVDDDSLFP--------DFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLI 745

  Fly   758 LNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDP-HLLCYSC-------VQLPE 814
            ||||.||:.|:..:...||.|:.||||:|:|.     ....|:.| |::|::.       ..||:
 Worm   746 LNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQ-----ESFIEASPLHVVCHAVPPTTSNGSMLPK 805

  Fly   815 GRDDDYKTASSKGSSSSATSFRASVLK-----------SVCRHRRHLRLEALRTLILADNLLTRI 868
            .|:...:...|:..|:..:....||.:           ..|.|:||..||.|:||.||.|.|..|
 Worm   806 RRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSI 870

  Fly   869 QLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGN 933
            .: |:.|                   |||:.|.|:::|:::|.|.:.|..:..|:.||:||:|||
 Worm   871 SV-TNAA-------------------SKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGN 915

  Fly   934 VNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMV 998
            ..|.||||..|:|||||:|:.:||.|:|||.||:..:..||::||.|||:|.|:::.|..::||:
 Worm   916 TAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMI 980

  Fly   999 VGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVG 1063
            :|..|:|||.:.|.|.:.|                          ...|...||       .|..
 Worm   981 LGSDGVGKSVIWDALCKEA--------------------------VQKRQPIHS-------ETGV 1012

  Fly  1064 VDIGTWICE-KRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAEL 1127
            :....|..| ||.:...:.|||.|...|||||:||::|||||||||||.||||:|:||.:.||:|
 Worm  1013 IRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQL 1077

  Fly  1128 LQWLGNIQARAPNSPVIIVGTHFDAVGESIS---PQKAEQLQQLIREKFIAIPDAEKIGLPRVID 1189
            ..||.||.||||||.||:|||:.|.|..:.|   |...:.::|.:|.::: :.||:|.||||::|
 Worm  1078 DTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYM-VADADKSGLPRIVD 1141

  Fly  1190 SIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDP 1254
            .|.|:..:.:::..|.|.||.||.::|.  .||..:.|:||:|||||..:...:....|..|:..
 Worm  1142 VILINSTSRNDVKALLNTIYRTAWEVRM--GKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPA 1204

  Fly  1255 VLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDML 1319
            |:..|.|:..|.::|.....:.|||..|...|.|:.|:.|.|:.::||||||..|:||.||.:.|
 Worm  1205 VMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFL 1269

  Fly  1320 AHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGN----RSYIVSLLNKFEVALTWDSRTLLI 1380
            ..||.:|  :|..|.|::..|.:....||.:   :|.    ::.::.||:|||:||....|.|||
 Worm  1270 TSVVILR--SPNLPAGLLSTDAINPHTRSFK---SGALLMLKTQLLDLLHKFELALATQPRQLLI 1329

  Fly  1381 PSLLPSQ-EAATPNSGSTVKLSQRSRGRSLGC-SVSQEVNLNNLIYEQRSAPSSSSSSASV---- 1439
            |||||.: ...:....|.||:..:....::.| |.:.....:.|   :|::|:..:...|.    
 Worm  1330 PSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPL---RRTSPTDQNGVGSEDVML 1391

  Fly  1440 ------SQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYM-ASQDYADF-DLRTSLEQD 1496
                  .|.||||..:.|.||||||||:|||:.|:.:..||..::| .|.|.|.. |:.|. ...
 Worm  1392 QFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATK-HAK 1455

  Fly  1497 TQWNLWQTGLALYYGPILIFKIWE-VPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEV 1560
            .:|.:||||:.|:.....:|.:.: :|..:. |...:.....|.|.:|.. |...|..|      
 Worm  1456 AEWVVWQTGIELHVKGHSLFTLKQFLPLAEV-RDIDYSAIDMRAKDEQKR-WRTWNQPS------ 1512

  Fly  1561 YFPLYEVNIS----QEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTS 1621
            :.|:.|:.::    .....:.|:|  .::..:...::|||:..|.:|.|||||||:|||||||:|
 Worm  1513 HRPIVEMVVNSLSISAASQHGRKL--SMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSS 1575

  Fly  1622 EGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGAL 1686
            ||..|::|.||||:|:           .|.|       |....||..:.|               
 Worm  1576 EGDLLVSRYVLCPQCV-----------RDAE-------RNGSRSRTSSSA--------------- 1607

  Fly  1687 NVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGS----SRNTSVDGHPGYHLPDNSNVCYA 1747
                        ..|||:         |.|..|.::.|    ||.|      |........|.:.
 Worm  1608 ------------SHRRSQ---------DDGELPITSSSHMKGSRTT------GDISKCRGGVVHC 1645

  Fly  1748 WMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFK 1812
            ::||||:|:....:.:.||.|....|.:||||.:||||.:..||..:.:.:..:||||||||||:
 Worm  1646 FVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFR 1710

  Fly  1813 ANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVL 1877
            |..:.......: ||.|||:||.||...:.|||.|:|.|..||.||.::.:|:||||:||||::|
 Worm  1711 ATVRQPNGELCE-VAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLL 1774

  Fly  1878 LTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLH 1942
            ..:||||::.|||:|..||:||:||||||.|:.||..:|::|..:.....:...:|.|||:||||
 Worm  1775 SRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLH 1839

  Fly  1943 RRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPS-GAKGFGGTEGFMAPEI 2006
            ...||||||||||||.|..|.|.   ||:..|.:|:.||||||...|| ||||||||||||||||
 Worm  1840 SAHIIYRDLKSENVLGWRFPAPF---SPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEI 1901

  Fly  2007 IRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLM 2071
            :|:|||||||:||||||||||:||.::|:.|||..|.:||.:|:|:||.|...|...||..|||:
 Worm  1902 VRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLL 1966

  Fly  2072 VLCWHEQPRRRPTASQIVSILSAPECIHLLDVV----AMPHSEKIVCGVFQSLVGMGDDERCGLE 2132
            |.||...|..||::||:|...:|||..|||||.    |:|.::.:..|:...:....|.|   .:
 Worm  1967 VHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFE---AQ 2028

  Fly  2133 LWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGAN-SRARSAQRLPKMNMLCCC 2196
            |||.  |..:.::.|:..|.:.| .||           :.|..|.. |:.|              
 Worm  2029 LWLS--GREMVVMGCTQYGFVDQ-KSI-----------ELPHRGKYVSKVR-------------- 2065

  Fly  2197 LVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDA 2261
               :::|..|..|.:..|..|  .|...::..|::                     ||.  |:.|
 Worm  2066 ---DSVWSCDECGQVTVYGIS--LHETGHLQLPSL---------------------NGT--LICA 2102

  Fly  2262 TQMPSN---CAFAEGSFVLTEIC-SGFVLHAACSVVVDGIYE--------------LWCGEIAGK 2308
            .::.||   ...::...||.::. |..|.|..   .:|..||              :|.|...|:
 Worm  2103 PELISNDVLILISDKQIVLLKLSESNSVSHLG---TIDSPYEIRTATFLGNGSTRQIWAGHSEGR 2164

  Fly  2309 INVFPLNENGVSGHQALCHSEEPNLIEDVKVARM---CSNESHVFSCLYPGCMVYQWDVISKRIE 2370
            |::     :.::.:.:...|....|.:|..:.|.   ..:...|:..|.....|...:|..:::.
 Worm  2165 ISI-----HHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVT 2224

  Fly  2371 NKLDCSKLLPCSESLQSIAID-EHVNLIKCQISALAAHN-SELYIGTTWGCLIVAELHTLRPISV 2433
            ..||..|::|.||::.:|.:: ...|.:.| |..|..:: .:|||||:.|.|::|...||:|:|.
 Worm  2225 GSLDIRKVMPGSETIHTIDMEMASQNYVTC-IGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSA 2288

  Fly  2434 FRPYENEIKSI-----------------------------------------------ITLSKDN 2451
            .||:|.:|.||                                               .|:....
 Worm  2289 CRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQG 2353

  Fly  2452 VPLIATIGRRYRSLISRYVDSAESSTKSSAVSTPTHGAAKSVPPADVDNHIHCLLWRAKHW 2512
            ..|:..|||::|||..|:|  ||...                  |||   ....:||.:.|
 Worm  2354 AALVVCIGRQFRSLSHRFV--AEEKL------------------ADV---YSIAVWRTEEW 2391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 24/91 (26%)
ANK 146..286 CDD:238125 36/140 (26%)
ANK repeat 146..177 CDD:293786 8/30 (27%)
Ank_4 179..232 CDD:290365 14/52 (27%)
ANK repeat 179..209 CDD:293786 9/29 (31%)
Ank_2 216..389 CDD:289560 34/173 (20%)
ANK 361..477 CDD:238125 33/116 (28%)
ANK repeat 361..390 CDD:293786 9/28 (32%)
Ank_2 364..464 CDD:289560 26/99 (26%)
ANK repeat 406..435 CDD:293786 7/28 (25%)
ANK repeat 437..464 CDD:293786 6/26 (23%)
LRR_8 <544..580 CDD:290566 19/35 (54%)
leucine-rich repeat 547..569 CDD:275380 10/21 (48%)
LRR_8 569..629 CDD:290566 25/62 (40%)
leucine-rich repeat 570..595 CDD:275380 10/26 (38%)
leucine-rich repeat 596..618 CDD:275380 7/22 (32%)
leucine-rich repeat 619..641 CDD:275380 11/21 (52%)
leucine-rich repeat 642..676 CDD:275380 11/42 (26%)
leucine-rich repeat 677..730 CDD:275380 12/54 (22%)
LRR_8 729..788 CDD:290566 23/58 (40%)
leucine-rich repeat 731..754 CDD:275380 7/22 (32%)
LRR_8 855..933 CDD:290566 25/77 (32%)
leucine-rich repeat 855..901 CDD:275380 13/45 (29%)
leucine-rich repeat 902..924 CDD:275380 6/21 (29%)
leucine-rich repeat 925..949 CDD:275380 15/23 (65%)
P-loop_NTPase 993..1211 CDD:304359 85/221 (38%)
COR 1230..1471 CDD:292713 87/256 (34%)
STYKc 1796..2092 CDD:214568 161/296 (54%)
STKc_LRRK 1801..2095 CDD:270902 161/294 (55%)
lrk-1NP_492839.4 Ank_2 29..121 CDD:289560
ANK 51..218 CDD:238125 25/95 (26%)
ANK repeat 56..88 CDD:293786
ANK repeat 90..121 CDD:293786
ANK 192..337 CDD:238125 37/146 (25%)
ANK repeat 197..228 CDD:293786 8/30 (27%)
Ank_2 202..286 CDD:289560 23/83 (28%)
ANK repeat 230..262 CDD:293786 10/31 (32%)
Ank_2 269..390 CDD:289560 33/172 (19%)
ANK 312..456 CDD:238125 39/196 (20%)
ANK repeat 361..390 CDD:293786 9/29 (31%)
Ank_2 366..472 CDD:289560 32/109 (29%)
ANK repeat 398..432 CDD:293786 7/33 (21%)
LRR_RI <512..>639 CDD:238064 54/133 (41%)
leucine-rich repeat 534..555 CDD:275380 9/20 (45%)
LRR_8 554..615 CDD:290566 25/63 (40%)
leucine-rich repeat 556..580 CDD:275380 10/26 (38%)
leucine-rich repeat 581..604 CDD:275380 7/22 (32%)
leucine-rich repeat 605..627 CDD:275380 11/21 (52%)
leucine-rich repeat 628..654 CDD:275380 8/25 (32%)
leucine-rich repeat 655..684 CDD:275380 8/38 (21%)
leucine-rich repeat 687..718 CDD:275380 7/38 (18%)
LRR_8 718..776 CDD:290566 23/57 (40%)
leucine-rich repeat 719..742 CDD:275380 7/22 (32%)
leucine-rich repeat 743..765 CDD:275380 9/21 (43%)
leucine-rich repeat 803..856 CDD:275380 12/52 (23%)
LRR_8 857..915 CDD:290566 25/77 (32%)
leucine-rich repeat 857..883 CDD:275380 13/45 (29%)
leucine-rich repeat 884..906 CDD:275380 6/21 (29%)
leucine-rich repeat 907..931 CDD:275380 15/23 (65%)
P-loop_NTPase 977..1160 CDD:304359 83/216 (38%)
COR <1239..>1336 CDD:292713 41/101 (41%)
S_TKc 1698..1983 CDD:214567 159/288 (55%)
PKc_like 1699..1990 CDD:304357 161/294 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157807
Domainoid 1 1.000 262 1.000 Domainoid score I1044
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H70945
Inparanoid 1 1.050 1027 1.000 Inparanoid score I141
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45565
OrthoDB 1 1.010 - - D10820at33208
OrthoFinder 1 1.000 - - FOG0007008
OrthoInspector 1 1.000 - - oto18392
orthoMCL 1 0.900 - - OOG6_105040
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2620
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.700

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