DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrk and mom-4

DIOPT Version :9

Sequence 1:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster
Sequence 2:	NP_492620.1	Gene:	mom-4 / 172842	WormBaseID:	WBGene00003396	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	454	Identity:	100/454 - (22%)
Similarity:	172/454 - (37%)	Gaps:	124/454 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1784 DIPDKHTIPSECI--IKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALM 1846
            |||:   |.::||  :....||:|.:|.|.|...:......|:|.|:|....:......:|:.:|
Worm    40 DIPE---IQAQCIDNLNSHYLGKGTYGLVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVM 101

  Fly  1847 AFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP---LALVLELAPLGGL 1908
                    ||                      ...||||:.:.|:...|   ..:|:|....|.:
Worm   102 --------WD----------------------LRNHPNIIKIYGLYKSPRNGQGVVMEYMDCGSM 136

  Fly  1909 DALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNL 1973
            ..||  |.|:..:.......:.:.|.:.|:::.|....::||||.:|:|:        .|..|.:
Worm   137 ADLL--YDRTHINYTIDHVASWMFQLSSAVDFFHSNSQVHRDLKLQNMLL--------SDRYRTM 191

  Fly  1974 VHIKIADYGI---SRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLR 2035
               |:.|:|.   ..|:..|..    ||...||||:.|.   |:|..|.|.:|.|:.:::.|:..
Worm   192 ---KLCDFGTFTSMHQSMTSNR----GTPITMAPEVFRC---EQYNMKSDIYSIGIIMWQIIARN 246

  Fly  2036 QPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHL 2100
            .|:....|:...:...:...|..:|.:......:....||::....|||:|         ||:..
Worm   247 HPYRRDLSVPGLLYNVATANLRPQELECNPILSEFYKKCWNDNADIRPTSS---------ECVEY 302

  Fly  2101 LDVV-------AMPHSEKIVCGVFQ---------SLVGMGDDERCGLELWLPSFGSRIDILDCSP 2149
            ..::       ::|.|:....|..:         :::|             .|.||.|...:.:|
Worm   303 FTLLKDEYPNGSVPLSDSSTNGPAETPPPHAHRPTMLG-------------TSSGSGIGSNNRTP 354

  Fly  2150 SGSLL-----------QCNSISCSPQPQVAPPKTP-ENGAN-------------SRARSAQRLP 2188
            :.|.|           :..|.:...||.:..|..| |.||:             .||:|.||.|
Worm   355 TASKLLNPQQPGQGHRRNRSETFVVQPDLPYPTVPGEAGASRIPKSQSEAKNFRDRAKSEQRQP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	68/303 (22%)
		STKc_LRRK	1801..2095	CDD:270902	67/299 (22%)
mom-4	NP_492620.1	PKc_like	57..303	CDD:304357	69/304 (23%)
mom-4	NP_492620.1	S_TKc	57..301	CDD:214567	69/302 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900